May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
FOCA - Probable formate transporter 1
UniProt: P0AC23 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11258
Length: 285 (270)
Sequences: 1034
Seq/Len: 3.83
FOCA
Paralog alert: 0.56 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FOCA FOCB NIRC YFDC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
165_V 264_I 6.77 1.00
165_V 260_I 4.756 1.00
260_I 264_I 3.642 1.00
38_A 120_G 3.19 1.00
164_A 258_V 2.983 1.00
100_K 107_W 2.902 1.00
35_F 120_G 2.772 1.00
39_I 127_L 2.706 1.00
23_G 99_A 2.459 1.00
118_Y 259_T 2.443 1.00
189_M 193_F 2.326 1.00
161_F 257_P 2.143 1.00
76_S 196_V 2.119 1.00
46_S 128_F 2.086 1.00
114_W 263_I 1.958 1.00
80_I 192_A 1.943 1.00
51_F 201_M 1.929 1.00
217_I 250_F 1.808 0.99
246_T 249_N 1.773 0.99
55_A 70_V 1.769 0.99
173_L 269_L 1.761 0.99
90_F 94_V 1.738 0.99
11_L 14_A 1.705 0.99
159_H 167_L 1.635 0.99
159_H 164_A 1.634 0.99
52_Y 71_G 1.593 0.98
151_Q 154_D 1.59 0.98
35_F 123_V 1.586 0.98
119_F 123_V 1.583 0.98
85_C 180_W 1.56 0.98
66_M 70_V 1.557 0.98
118_Y 210_S 1.554 0.98
35_F 116_N 1.553 0.98
27_A 105_I 1.546 0.98
187_S 190_D 1.543 0.98
130_L 134_L 1.528 0.98
90_F 263_I 1.507 0.97
47_I 173_L 1.505 0.97
81_L 177_L 1.486 0.97
122_L 214_M 1.483 0.97
93_T 113_N 1.481 0.97
118_Y 255_L 1.459 0.97
51_F 200_A 1.451 0.97
210_S 259_T 1.441 0.96
185_G 190_D 1.431 0.96
181_M 194_I 1.411 0.96
34_T 116_N 1.367 0.95
56_T 71_G 1.364 0.95
78_G 203_V 1.355 0.94
129_V 219_M 1.352 0.94
160_T 163_E 1.329 0.94
43_V 46_S 1.329 0.94
169_I 264_I 1.3 0.93
169_I 268_L 1.297 0.93
213_N 254_N 1.287 0.92
73_I 196_V 1.283 0.92
47_I 128_F 1.282 0.92
161_F 164_A 1.274 0.92
221_I 250_F 1.27 0.91
123_V 126_L 1.268 0.91
115_L 119_F 1.266 0.91
39_I 123_V 1.265 0.91
259_T 263_I 1.253 0.91
131_L 170_L 1.251 0.91
248_M 252_T 1.242 0.90
110_L 114_W 1.223 0.89
172_N 202_F 1.209 0.89
171_A 211_I 1.201 0.88
100_K 105_I 1.193 0.88
73_I 200_A 1.183 0.87
108_G 112_K 1.174 0.87
43_V 173_L 1.173 0.87
83_V 195_M 1.168 0.86
31_P 116_N 1.162 0.86
115_L 168_G 1.154 0.85
14_A 186_R 1.154 0.85
95_L 278_Y 1.153 0.85
161_F 165_V 1.15 0.85
40_T 44_F 1.144 0.85
44_F 81_L 1.139 0.84
83_V 179_V 1.134 0.84
229_P 234_A 1.129 0.84
202_F 213_N 1.124 0.83
210_S 258_V 1.124 0.83
21_E 104_R 1.124 0.83
34_T 112_K 1.12 0.83
211_I 214_M 1.108 0.82
75_F 213_N 1.102 0.81
100_K 110_L 1.096 0.81
44_F 87_A 1.096 0.81
16_A 279_L 1.095 0.81
84_V 188_L 1.094 0.81
130_L 222_V 1.094 0.81
210_S 255_L 1.088 0.80
88_D 93_T 1.08 0.80
47_I 211_I 1.078 0.79
162_I 166_C 1.074 0.79
252_T 256_I 1.071 0.79
270_V 274_Y 1.07 0.79
90_F 259_T 1.069 0.79
266_G 271_G 1.066 0.78
184_S 188_L 1.065 0.78
111_A 115_L 1.063 0.78
111_A 256_I 1.059 0.78
107_W 111_A 1.056 0.77
37_L 180_W 1.055 0.77
41_A 90_F 1.045 0.76
122_L 251_I 1.044 0.76
247_V 251_I 1.042 0.76
195_M 199_V 1.038 0.76
129_V 222_V 1.034 0.75
161_F 260_I 1.033 0.75
10_L 18_V 1.032 0.75
23_G 26_K 1.03 0.75
28_T 109_Q 1.028 0.75
211_I 273_T 1.026 0.75
153_A 220_G 1.017 0.74
178_A 202_F 1.014 0.73
87_A 274_Y 1.013 0.73
35_F 39_I 1.013 0.73
85_C 274_Y 1.006 0.73
20_E 102_S 1.005 0.72
41_A 92_S 1.005 0.72
131_L 166_C 1.002 0.72
149_V 219_M 1 0.72
168_G 257_P 1 0.72
167_L 208_E 1 0.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3kcuA511000.041Contact Map0.775
3klyA50.98251000.063Contact Map0.741
3tdsE50.90881000.131Contact Map0.772
4fc4A100.88421000.161Contact Map0.733
3llqA20.863271.50.948Contact Map0.407
3zojA10.8772410.957Contact Map0.446
2o9gA10.80734.90.958Contact Map0.361
3iyzA10.8737270.961Contact Map0.022
3cn5A10.898225.80.961Contact Map0.399
2zz9A10.803511.40.967Contact Map0.336
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.3003 seconds.