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OPENSEQ.org
YFDC - Inner membrane protein YfdC
UniProt: P37327 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12420
Length: 310 (253)
Sequences: 893
Seq/Len: 3.53
YFDC
Paralog alert: 0.55 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FOCA FOCB NIRC YFDC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
188_F 266_C 6.918 1.00
188_F 262_A 4.768 1.00
262_A 266_C 3.424 1.00
63_A 146_G 3.074 1.00
187_M 260_T 2.961 1.00
60_L 146_G 2.817 1.00
64_I 153_I 2.649 1.00
48_G 123_P 2.535 1.00
124_V 133_V 2.421 1.00
71_G 154_A 2.354 1.00
144_L 261_L 2.349 1.00
184_P 259_P 2.242 1.00
99_T 217_I 2.046 1.00
140_W 265_I 2.01 1.00
113_F 117_T 1.961 1.00
103_I 213_I 1.919 1.00
248_H 251_D 1.83 0.99
108_A 203_W 1.753 0.99
104_I 200_T 1.734 0.99
77_K 94_E 1.688 0.99
238_I 252_F 1.676 0.99
196_W 271_I 1.665 0.99
192_I 270_F 1.64 0.98
76_A 222_L 1.586 0.98
60_L 142_V 1.541 0.97
148_I 235_S 1.537 0.97
113_F 265_I 1.537 0.97
59_L 142_V 1.537 0.97
144_L 231_I 1.497 0.97
174_K 177_M 1.493 0.97
60_L 149_L 1.484 0.97
182_N 190_N 1.455 0.96
96_L 221_W 1.443 0.96
194_S 232_V 1.411 0.95
80_F 93_L 1.409 0.95
52_L 131_S 1.396 0.95
116_N 139_L 1.395 0.95
208_A 211_A 1.39 0.95
231_I 261_L 1.372 0.94
36_R 39_A 1.366 0.94
242_V 252_F 1.357 0.94
144_L 257_A 1.343 0.93
204_M 215_V 1.34 0.93
192_I 266_C 1.338 0.93
183_T 186_E 1.337 0.93
101_G 224_A 1.335 0.93
72_A 196_W 1.327 0.93
141_G 145_L 1.321 0.92
46_Q 128_P 1.319 0.92
133_V 137_I 1.301 0.92
253_I 258_L 1.29 0.91
68_L 71_G 1.29 0.91
64_I 149_L 1.286 0.91
172_F 240_Y 1.267 0.90
187_M 191_A 1.253 0.89
272_F 276_S 1.253 0.89
145_L 149_L 1.249 0.89
53_E 135_L 1.244 0.89
268_G 273_A 1.229 0.88
182_N 187_M 1.217 0.88
184_P 187_M 1.209 0.87
137_I 141_G 1.206 0.87
231_I 257_A 1.206 0.87
106_I 202_V 1.2 0.87
118_V 272_F 1.187 0.86
157_A 193_I 1.185 0.86
185_S 189_A 1.168 0.85
39_A 209_G 1.167 0.84
148_I 152_G 1.162 0.84
76_A 221_W 1.159 0.84
155_A 243_F 1.157 0.84
231_I 260_T 1.156 0.84
184_P 262_A 1.149 0.83
250_S 254_W 1.148 0.83
124_V 127_K 1.148 0.83
234_G 256_F 1.144 0.83
119_T 123_P 1.127 0.82
118_V 232_V 1.126 0.81
68_L 196_W 1.126 0.81
155_A 240_Y 1.126 0.81
134_G 138_R 1.098 0.79
113_F 261_L 1.095 0.79
270_F 275_M 1.086 0.78
111_Q 116_N 1.085 0.78
70_M 74_L 1.082 0.78
149_L 152_G 1.082 0.78
124_V 131_S 1.081 0.78
74_L 237_E 1.08 0.78
195_G 223_I 1.077 0.77
78_G 236_V 1.075 0.77
169_R 172_F 1.071 0.77
229_T 256_F 1.07 0.77
232_V 235_S 1.066 0.76
110_Q 276_S 1.064 0.76
56_A 142_V 1.061 0.76
232_V 275_M 1.056 0.75
56_A 156_W 1.054 0.75
203_W 272_F 1.046 0.74
69_S 104_I 1.042 0.74
48_G 120_A 1.042 0.74
35_S 43_H 1.039 0.74
106_I 216_I 1.039 0.74
176_G 241_L 1.038 0.74
48_G 51_E 1.035 0.73
254_W 258_L 1.032 0.73
40_I 207_A 1.031 0.73
108_A 276_S 1.031 0.73
261_L 265_I 1.029 0.73
64_I 209_G 1.027 0.72
96_L 214_V 1.02 0.72
65_A 69_S 1.019 0.72
178_D 181_K 1.017 0.71
98_Y 223_I 1.016 0.71
71_G 194_S 1.015 0.71
156_W 243_F 1.013 0.71
59_L 138_R 1.011 0.71
96_L 217_I 1.011 0.71
136_L 140_W 1.01 0.71
45_R 126_Q 1.006 0.70
187_M 242_V 1.001 0.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3kcuA50.83551000.314Contact Map0.765
3klyA50.81941000.319Contact Map0.731
3tdsE50.8291000.338Contact Map0.77
4fc4A100.81611000.355Contact Map0.743
3iyzA10.916193.30.945Contact Map0.033
3zojA10.845293.20.946Contact Map0.468
3c02A10.738784.50.954Contact Map0.379
2zz9A10.780681.40.956Contact Map0.337
2kncB10.196879.60.956Contact Map0.411
3llqA20.783976.10.958Contact Map0.388
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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