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OPENSEQ.org

ENTH - Proofreading thioesterase EntH
UniProt: P0A8Y8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11105
Length: 137 (128)
Sequences: 3052
Seq/Len: 23.84

ENTH
Paralog alert: 0.54 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: ENTH PAAI YDII YIGI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
83_T 111_N 3.263 1.00
29_T 39_E 3.044 1.00
39_E 97_K 2.943 1.00
37_E 101_V 2.627 1.00
27_V 39_E 2.51 1.00
101_V 119_F 2.492 1.00
30_R 35_V 2.479 1.00
38_A 65_L 2.472 1.00
30_R 37_E 2.335 1.00
40_M 57_A 2.076 1.00
70_G 112_Q 1.991 1.00
32_G 35_V 1.976 1.00
117_V 125_R 1.967 1.00
62_A 129_C 1.922 1.00
35_V 103_Q 1.907 1.00
91_R 124_R 1.872 1.00
59_A 85_L 1.864 1.00
65_L 100_G 1.794 1.00
66_G 116_I 1.784 1.00
35_V 101_V 1.762 1.00
59_A 89_H 1.734 1.00
39_E 99_R 1.646 1.00
84_E 88_T 1.637 1.00
120_D 124_R 1.631 1.00
66_G 131_L 1.608 1.00
59_A 87_A 1.565 1.00
37_E 99_R 1.562 1.00
103_Q 115_E 1.51 1.00
103_Q 117_V 1.502 1.00
41_P 97_K 1.485 1.00
100_G 116_I 1.483 1.00
115_E 128_T 1.479 1.00
62_A 118_V 1.454 1.00
104_P 107_L 1.413 1.00
119_F 123_G 1.413 1.00
62_A 116_I 1.406 0.99
106_H 111_N 1.382 0.99
42_V 53_L 1.379 0.99
20_M 57_A 1.355 0.99
105_L 115_E 1.349 0.99
58_S 127_C 1.34 0.99
87_A 127_C 1.332 0.99
93_V 126_C 1.289 0.99
34_D 72_M 1.288 0.99
23_H 45_R 1.255 0.99
56_G 60_A 1.254 0.99
53_L 98_V 1.201 0.98
43_D 46_T 1.2 0.98
63_E 82_G 1.2 0.98
9_L 13_N 1.183 0.98
115_E 130_R 1.172 0.98
117_V 128_T 1.165 0.97
105_L 128_T 1.143 0.97
29_T 37_E 1.14 0.97
58_S 118_V 1.135 0.97
27_V 41_P 1.124 0.97
20_M 60_A 1.12 0.96
73_M 107_L 1.101 0.96
93_V 98_V 1.094 0.96
70_G 133_T 1.082 0.96
58_S 126_C 1.077 0.95
91_R 106_H 1.071 0.95
84_E 130_R 1.032 0.94
110_Q 134_A 1.027 0.94
52_L 81_V 1.014 0.93
88_T 132_G 1.001 0.92
104_P 114_W 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vh9A2199.90.227Contact Map0.735
1vh5A2199.90.227Contact Map0.869
3lmbA20.985499.90.243Contact Map0.685
1yocA20.992799.90.253Contact Map0.642
1o0iA2199.90.253Contact Map0.794
1sh8A20.956299.90.259Contact Map0.713
1t82A40.978199.90.269Contact Map0.629
3e8pA40.992799.90.269Contact Map0.799
3gekA40.875999.90.275Contact Map0.844
3f1tA40.985499.90.278Contact Map0.77

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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