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OPENSEQ.org

PAAI - Acyl-coenzyme A thioesterase PaaI
UniProt: P76084 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13743
Length: 140 (129)
Sequences: 2936
Seq/Len: 22.76

PAAI
Paralog alert: 0.54 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: ENTH PAAI YDII YIGI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
78_S 107_T 3.365 1.00
27_I 37_T 3.163 1.00
37_T 93_T 3.093 1.00
35_V 97_T 2.704 1.00
25_D 37_T 2.611 1.00
36_V 63_A 2.505 1.00
97_T 115_V 2.468 1.00
28_S 33_F 2.465 1.00
28_S 35_V 2.367 1.00
30_D 33_F 2.139 1.00
38_M 55_Q 2.132 1.00
113_E 121_T 1.994 1.00
33_F 99_Q 1.938 1.00
57_F 80_C 1.926 1.00
116_N 120_K 1.916 1.00
60_A 125_F 1.901 1.00
68_C 108_G 1.88 1.00
86_R 120_K 1.862 1.00
63_A 96_A 1.83 1.00
33_F 97_T 1.756 1.00
37_T 95_T 1.701 1.00
64_F 112_I 1.686 1.00
79_A 83_D 1.674 1.00
35_V 95_T 1.672 1.00
57_F 84_F 1.664 1.00
64_F 127_G 1.647 1.00
57_F 82_I 1.595 1.00
99_Q 111_D 1.506 1.00
102_H 107_T 1.469 1.00
111_D 124_L 1.467 1.00
99_Q 113_E 1.465 1.00
96_A 112_I 1.459 1.00
40_V 51_C 1.434 1.00
60_A 112_I 1.412 1.00
100_V 103_Q 1.405 0.99
39_T 93_T 1.396 0.99
56_L 123_A 1.395 0.99
18_C 55_Q 1.395 0.99
82_I 123_A 1.356 0.99
60_A 114_I 1.344 0.99
101_R 111_D 1.33 0.99
115_V 119_Q 1.299 0.99
21_A 43_Q 1.297 0.99
54_G 58_S 1.289 0.99
41_T 44_M 1.288 0.99
88_G 122_V 1.281 0.99
51_C 94_L 1.271 0.99
92_D 117_Q 1.267 0.99
27_I 35_V 1.184 0.98
101_R 124_L 1.162 0.97
61_D 77_A 1.147 0.97
106_Q 130_H 1.136 0.97
25_D 39_T 1.121 0.97
111_D 126_R 1.12 0.96
56_L 114_I 1.108 0.96
113_E 124_L 1.104 0.96
32_G 70_S 1.1 0.96
18_C 58_S 1.075 0.95
94_L 114_I 1.06 0.95
86_R 102_H 1.059 0.95
56_L 122_V 1.058 0.95
68_C 129_S 1.037 0.94
42_A 45_L 1.035 0.94
88_G 94_L 1.032 0.94
38_M 59_L 1.023 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3f1tA4199.90.281Contact Map0.784
3e8pA40.935799.90.285Contact Map0.835
1sh8A20.964399.90.287Contact Map0.741
1yocA20.9599.90.291Contact Map0.668
3e29A40.978699.90.296Contact Map0.839
1t82A40.928699.90.299Contact Map0.656
3hduA30.935799.90.303Contact Map0.757
3gekA40.892999.90.313Contact Map0.857
2fs2A2199.90.314Contact Map0.814
3e1eA80.9599.90.315Contact Map0.886

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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