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OPENSEQ.org
YQEF - Probable acetyl-CoA acetyltransferase
UniProt: Q46939 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13097
Length: 393 (392)
Sequences: 7207
Seq/Len: 18.39
YQEF
Paralog alert: 0.73 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: ATOB FADA FADI PAAJ YQEF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
180_L 225_A 3.428 1.00
181_S 185_K 3.422 1.00
263_K 267_L 3.28 1.00
174_L 328_K 3.169 1.00
3_D 261_E 3.137 1.00
36_A 39_E 3.02 1.00
188_A 192_A 3.007 1.00
361_L 373_G 2.983 1.00
107_A 110_V 2.917 1.00
95_L 358_L 2.902 1.00
299_C 303_V 2.85 1.00
5_V 264_A 2.838 1.00
181_S 184_Q 2.827 1.00
261_E 265_R 2.812 1.00
263_K 266_A 2.755 1.00
37_L 257_M 2.711 1.00
175_Q 240_S 2.628 1.00
299_C 388_T 2.596 1.00
102_I 258_M 2.585 1.00
34_V 111_I 2.496 1.00
102_I 260_S 2.346 1.00
173_Q 177_A 2.294 1.00
277_A 303_V 2.235 1.00
9_A 359_V 2.227 1.00
365_M 370_A 2.224 1.00
196_K 214_D 2.197 1.00
166_R 236_D 2.192 1.00
312_L 339_V 2.189 1.00
2_K 262_A 2.176 1.00
10_L 40_R 2.137 1.00
191_D 221_T 2.132 1.00
228_L 244_G 2.119 1.00
254_A 355_C 2.078 1.00
44_P 47_A 2.055 1.00
218_Q 248_S 2.045 1.00
277_A 299_C 2.02 1.00
305_W 372_K 2.015 1.00
190_I 219_P 2 1.00
259_M 264_A 1.987 1.00
196_K 215_T 1.984 1.00
171_S 174_L 1.979 1.00
98_A 110_V 1.972 1.00
109_I 259_M 1.948 1.00
272_L 366_V 1.931 1.00
311_D 370_A 1.904 1.00
7_V 259_M 1.875 1.00
30_G 53_L 1.831 1.00
32_L 202_V 1.824 1.00
30_G 69_S 1.819 1.00
296_T 376_T 1.818 1.00
190_I 199_I 1.781 1.00
273_A 362_V 1.778 1.00
340_N 364_E 1.773 1.00
164_L 170_I 1.761 1.00
310_V 372_K 1.759 1.00
20_A 213_V 1.74 1.00
187_R 191_D 1.732 1.00
366_V 391_R 1.706 1.00
98_A 258_M 1.694 1.00
37_L 41_T 1.694 1.00
305_W 310_V 1.692 1.00
158_G 235_F 1.691 1.00
47_A 267_L 1.69 1.00
364_E 368_R 1.687 1.00
34_V 69_S 1.675 1.00
310_V 313_I 1.652 1.00
177_A 181_S 1.641 1.00
181_S 334_E 1.64 1.00
187_R 219_P 1.623 1.00
297_R 301_E 1.619 1.00
327_G 334_E 1.617 1.00
274_R 390_E 1.615 1.00
108_D 260_S 1.591 1.00
36_A 200_V 1.588 1.00
327_G 337_V 1.585 1.00
190_I 215_T 1.578 1.00
227_G 230_R 1.574 1.00
333_D 336_R 1.569 1.00
307_L 313_I 1.557 1.00
369_N 391_R 1.524 1.00
194_R 364_E 1.519 1.00
310_V 388_T 1.51 1.00
259_M 263_K 1.507 1.00
108_D 263_K 1.499 1.00
53_L 113_G 1.497 1.00
32_L 200_V 1.49 1.00
36_A 40_R 1.489 1.00
312_L 364_E 1.485 1.00
82_I 97_L 1.464 1.00
8_G 37_L 1.46 1.00
374_L 388_T 1.456 1.00
364_E 367_K 1.45 1.00
174_L 177_A 1.447 1.00
305_W 388_T 1.433 1.00
256_V 355_C 1.428 1.00
180_L 184_Q 1.42 1.00
194_R 340_N 1.415 1.00
117_N 120_R 1.406 0.99
203_M 212_V 1.405 0.99
3_D 274_R 1.391 0.99
101_A 107_A 1.39 0.99
197_D 366_V 1.378 0.99
362_V 366_V 1.372 0.99
33_V 255_A 1.37 0.99
89_G 385_V 1.365 0.99
279_A 299_C 1.361 0.99
260_S 263_K 1.353 0.99
313_I 374_L 1.352 0.99
297_R 329_M 1.349 0.99
35_K 39_E 1.347 0.99
371_R 390_E 1.344 0.99
184_Q 222_D 1.337 0.99
8_G 41_T 1.332 0.99
5_V 274_R 1.324 0.99
100_Q 106_E 1.317 0.99
339_V 368_R 1.309 0.99
295_A 386_A 1.304 0.99
4_V 258_M 1.299 0.99
77_N 284_D 1.297 0.99
223_A 228_L 1.292 0.99
111_I 257_M 1.285 0.99
14_I 352_A 1.284 0.99
28_E 72_K 1.283 0.99
300_L 307_L 1.282 0.99
21_L 213_V 1.278 0.99
55_Q 58_T 1.274 0.99
294_Y 297_R 1.274 0.99
311_D 365_M 1.26 0.99
95_L 256_V 1.255 0.99
306_Q 309_E 1.251 0.99
49_D 108_D 1.245 0.98
298_R 301_E 1.245 0.98
283_V 290_I 1.239 0.98
359_V 363_H 1.239 0.98
92_L 358_L 1.234 0.98
339_V 364_E 1.228 0.98
124_V 142_S 1.226 0.98
361_L 375_A 1.222 0.98
53_L 255_A 1.222 0.98
14_I 346_L 1.217 0.98
5_V 261_E 1.216 0.98
51_V 70_A 1.213 0.98
65_P 115_Q 1.213 0.98
275_I 387_L 1.212 0.98
167_E 287_L 1.198 0.98
49_D 107_A 1.195 0.98
48_V 109_I 1.193 0.98
177_A 225_A 1.184 0.98
31_S 72_K 1.182 0.98
187_R 222_D 1.18 0.98
89_G 379_I 1.179 0.98
109_I 263_K 1.171 0.98
5_V 259_M 1.171 0.98
358_L 389_I 1.169 0.97
96_H 387_L 1.156 0.97
98_A 112_A 1.15 0.97
10_L 200_V 1.144 0.97
52_I 110_V 1.14 0.97
170_I 175_Q 1.14 0.97
9_A 363_H 1.139 0.97
204_T 210_T 1.134 0.97
170_I 324_L 1.133 0.97
184_Q 188_A 1.129 0.97
24_H 32_L 1.125 0.97
96_H 278_F 1.125 0.97
279_A 298_R 1.118 0.96
95_L 258_M 1.118 0.96
311_D 336_R 1.116 0.96
194_R 367_K 1.115 0.96
33_V 253_A 1.114 0.96
277_A 302_R 1.113 0.96
178_Y 323_A 1.11 0.96
312_L 368_R 1.109 0.96
93_K 97_L 1.099 0.96
38_I 43_V 1.09 0.96
181_S 335_R 1.089 0.96
8_G 40_R 1.089 0.96
310_V 374_L 1.087 0.96
180_L 222_D 1.084 0.96
205_Q 210_T 1.083 0.96
198_E 360_S 1.076 0.95
180_L 228_L 1.072 0.95
332_W 337_V 1.07 0.95
205_Q 211_L 1.07 0.95
13_P 213_V 1.068 0.95
12_T 33_V 1.063 0.95
315_A 376_T 1.057 0.95
290_I 293_V 1.05 0.94
158_G 234_S 1.049 0.94
296_T 374_L 1.049 0.94
303_V 388_T 1.046 0.94
287_L 290_I 1.045 0.94
34_V 75_L 1.041 0.94
6_I 389_I 1.041 0.94
277_A 388_T 1.039 0.94
293_V 297_R 1.032 0.94
262_A 266_A 1.031 0.94
225_A 229_A 1.03 0.94
356_R 360_S 1.028 0.94
38_I 75_L 1.02 0.93
203_M 209_Q 1.02 0.93
37_L 111_I 1.019 0.93
197_D 367_K 1.018 0.93
203_M 210_T 1.018 0.93
205_Q 209_Q 1.018 0.93
33_V 36_A 1.016 0.93
25_S 28_E 1.013 0.93
290_I 329_M 1.009 0.93
167_E 286_A 1.009 0.93
172_R 242_T 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vu1A40.99241000.186Contact Map0.826
4dd5A10.99241000.187Contact Map0.834
1ulqA80.99751000.191Contact Map0.844
4e1lA40.99491000.194Contact Map0.876
3ss6A20.99241000.198Contact Map0.827
2wu9A20.9721000.206Contact Map0.813
2iikA20.9721000.219Contact Map0.81
2ib8A40.98471000.22Contact Map0.773
1wl4A10.99241000.224Contact Map0.834
1wdkC20.96441000.226Contact Map0.782
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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