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OPENSEQ.org
FADA - 3-ketoacyl-CoA thiolase
UniProt: P21151 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10278
Length: 387 (384)
Sequences: 7183
Seq/Len: 18.71
FADA
Paralog alert: 0.73 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: ATOB FADA FADI PAAJ YQEF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
171_R 175_R 3.4 1.00
170_A 216_V 3.367 1.00
255_R 259_L 3.259 1.00
164_M 320_K 3.169 1.00
3_Q 253_E 3.124 1.00
356_L 368_G 2.996 1.00
37_S 40_A 2.99 1.00
178_A 182_S 2.976 1.00
110_A 113_C 2.91 1.00
291_A 295_A 2.843 1.00
171_R 174_A 2.833 1.00
253_E 257_H 2.829 1.00
98_L 353_S 2.826 1.00
5_V 256_A 2.804 1.00
255_R 258_E 2.717 1.00
38_L 249_L 2.669 1.00
165_Q 232_M 2.598 1.00
291_A 383_V 2.555 1.00
105_I 250_V 2.513 1.00
35_M 114_L 2.472 1.00
105_I 252_S 2.299 1.00
163_E 167_A 2.273 1.00
156_R 227_D 2.246 1.00
360_M 365_V 2.216 1.00
2_E 254_S 2.215 1.00
269_S 295_A 2.196 1.00
9_A 354_T 2.193 1.00
304_V 334_L 2.191 1.00
186_K 205_N 2.172 1.00
181_Q 212_P 2.132 1.00
10_I 41_R 2.122 1.00
219_L 236_G 2.099 1.00
246_A 350_A 2.082 1.00
161_S 164_M 2.025 1.00
209_V 240_A 2.014 1.00
46_E 49_A 2.012 1.00
297_L 367_F 2.001 1.00
186_K 206_Y 1.99 1.00
180_T 210_I 1.988 1.00
269_S 291_A 1.957 1.00
101_A 113_C 1.955 1.00
251_M 256_A 1.953 1.00
112_A 251_M 1.917 1.00
264_R 361_E 1.912 1.00
303_G 365_V 1.864 1.00
7_V 251_M 1.833 1.00
33_H 192_T 1.83 1.00
288_S 371_T 1.808 1.00
31_S 72_A 1.806 1.00
180_T 189_I 1.8 1.00
31_S 55_W 1.786 1.00
154_L 160_I 1.772 1.00
265_A 357_L 1.771 1.00
335_N 359_L 1.752 1.00
302_I 367_F 1.723 1.00
177_W 181_Q 1.703 1.00
21_A 204_F 1.701 1.00
361_E 386_R 1.696 1.00
359_L 363_K 1.687 1.00
148_G 226_F 1.686 1.00
38_L 42_N 1.68 1.00
101_A 250_V 1.674 1.00
297_L 302_I 1.67 1.00
49_A 259_L 1.664 1.00
177_W 210_I 1.644 1.00
35_M 72_A 1.638 1.00
302_I 305_F 1.61 1.00
289_K 293_K 1.6 1.00
167_A 171_R 1.587 1.00
319_I 329_D 1.581 1.00
266_R 385_E 1.58 1.00
171_R 329_D 1.57 1.00
37_S 190_I 1.562 1.00
111_Q 252_S 1.557 1.00
218_A 221_T 1.531 1.00
180_T 206_Y 1.531 1.00
328_I 331_K 1.529 1.00
364_D 386_R 1.527 1.00
299_A 305_F 1.522 1.00
319_I 332_I 1.51 1.00
304_V 359_L 1.504 1.00
184_A 359_L 1.498 1.00
111_Q 255_R 1.489 1.00
33_H 190_I 1.487 1.00
164_M 167_A 1.48 1.00
55_W 116_G 1.479 1.00
251_M 255_R 1.477 1.00
85_V 100_D 1.471 1.00
302_I 383_V 1.468 1.00
359_L 362_R 1.456 1.00
297_L 383_V 1.446 1.00
37_S 41_R 1.437 1.00
248_M 350_A 1.437 1.00
8_D 38_L 1.433 1.00
170_A 174_A 1.431 1.00
369_L 383_V 1.429 1.00
3_Q 266_R 1.409 1.00
305_F 369_L 1.392 0.99
193_G 203_Q 1.383 0.99
104_M 110_A 1.38 0.99
227_D 230_N 1.375 0.99
184_A 335_N 1.374 0.99
252_S 255_R 1.368 0.99
120_H 123_H 1.348 0.99
92_G 380_I 1.346 0.99
271_A 291_A 1.346 0.99
34_L 247_A 1.344 0.99
357_L 361_E 1.339 0.99
366_Q 385_E 1.335 0.99
174_A 213_E 1.334 0.99
8_D 42_N 1.33 0.99
36_R 40_A 1.327 0.99
334_L 363_K 1.311 0.99
289_K 321_D 1.31 0.99
187_N 361_E 1.309 0.99
287_A 381_A 1.304 0.99
80_H 276_D 1.302 0.99
5_V 266_R 1.299 0.99
53_I 73_A 1.295 0.99
193_G 201_L 1.285 0.99
103_R 109_D 1.285 0.99
292_L 299_A 1.283 0.99
286_P 289_K 1.282 0.99
14_M 347_C 1.278 0.99
275_C 282_Y 1.275 0.99
214_T 219_L 1.268 0.99
22_F 204_F 1.267 0.99
57_C 60_Q 1.266 0.99
29_D 75_L 1.264 0.99
98_L 248_M 1.263 0.99
4_V 250_V 1.262 0.99
14_M 341_L 1.251 0.99
298_S 301_D 1.243 0.98
114_L 249_L 1.242 0.98
290_L 293_K 1.242 0.98
303_G 360_M 1.241 0.98
95_M 353_S 1.233 0.98
68_I 118_V 1.228 0.98
51_D 111_Q 1.226 0.98
157_M 279_I 1.217 0.98
356_L 370_A 1.216 0.98
267_V 382_T 1.211 0.98
334_L 359_L 1.208 0.98
354_T 358_N 1.203 0.98
5_V 253_E 1.202 0.98
55_W 247_A 1.197 0.98
50_L 112_A 1.194 0.98
167_A 216_V 1.182 0.98
177_W 213_E 1.176 0.98
10_I 190_I 1.175 0.98
51_D 110_A 1.174 0.98
101_A 115_V 1.173 0.98
353_S 384_F 1.17 0.97
174_A 178_A 1.164 0.97
92_G 374_I 1.157 0.97
98_L 250_V 1.157 0.97
112_A 255_R 1.154 0.97
195_H 201_L 1.15 0.97
5_V 251_M 1.149 0.97
99_H 382_T 1.14 0.97
32_A 75_L 1.139 0.97
160_I 316_L 1.135 0.97
184_A 362_R 1.131 0.97
9_A 358_N 1.128 0.97
99_H 270_M 1.127 0.97
54_Y 113_C 1.125 0.97
271_A 290_L 1.117 0.96
303_G 331_K 1.112 0.96
8_D 41_R 1.112 0.96
160_I 165_Q 1.11 0.96
168_F 315_I 1.108 0.96
34_L 245_A 1.103 0.96
269_S 294_K 1.09 0.96
304_V 363_K 1.081 0.95
302_I 369_L 1.08 0.95
12_T 34_L 1.079 0.95
96_Q 100_D 1.078 0.95
148_G 225_A 1.077 0.95
39_L 45_L 1.072 0.95
170_A 219_L 1.071 0.95
13_P 204_F 1.053 0.95
25_V 33_H 1.05 0.94
254_S 258_E 1.04 0.94
34_L 37_S 1.038 0.94
188_E 355_T 1.038 0.94
162_R 234_T 1.036 0.94
351_R 355_T 1.036 0.94
324_L 332_I 1.036 0.94
269_S 383_V 1.035 0.94
282_Y 285_V 1.035 0.94
171_R 330_E 1.034 0.94
307_M 371_T 1.034 0.94
6_I 384_F 1.026 0.94
295_A 383_V 1.026 0.94
288_S 369_L 1.024 0.93
285_V 289_K 1.023 0.93
196_D 201_L 1.018 0.93
196_D 202_K 1.015 0.93
170_A 213_E 1.014 0.93
39_L 78_V 1.012 0.93
35_M 78_V 1.008 0.93
282_Y 321_D 1.008 0.93
157_M 278_S 1.004 0.93
279_I 282_Y 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1wdkC20.99741000.198Contact Map0.787
1ulqA80.98191000.2Contact Map0.845
2wu9A20.98711000.202Contact Map0.815
2vu1A40.97421000.202Contact Map0.826
4dd5A10.97161000.206Contact Map0.834
3goaA20.98971000.206Contact Map0.836
3ss6A20.97421000.212Contact Map0.829
4e1lA40.97421000.212Contact Map0.876
2iikA20.98451000.221Contact Map0.812
2ib8A40.97161000.234Contact Map0.78
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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