| UniProt: | P76503 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG14128 | ||
| Length: | 436 (412) | ||
| Sequences: | 6932 | ||
| Seq/Len: | 16.83 |
| FADI
Paralog alert: 0.73 [within 20: 0.10] - ratio of genomes with paralogs Cluster includes: ATOB FADA FADI PAAJ YQEF |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 208_R | 212_R | 3.603 | 1.00 | |
| 207_H | 250_L | 3.581 | 1.00 | |
| 289_R | 293_L | 3.406 | 1.00 | |
| 14_R | 287_E | 3.322 | 1.00 | |
| 47_E | 50_A | 3.227 | 1.00 | |
| 215_Q | 219_D | 3.227 | 1.00 | |
| 201_Q | 355_Q | 3.153 | 1.00 | |
| 405_T | 417_G | 3.127 | 1.00 | |
| 208_R | 211_Q | 3.027 | 1.00 | |
| 118_I | 121_G | 3.014 | 1.00 | |
| 326_A | 330_A | 3.008 | 1.00 | |
| 106_V | 402_I | 2.996 | 1.00 | |
| 287_E | 291_K | 2.952 | 1.00 | |
| 16_A | 290_A | 2.907 | 1.00 | |
| 289_R | 292_E | 2.827 | 1.00 | |
| 48_L | 283_I | 2.716 | 1.00 | |
| 326_A | 432_V | 2.69 | 1.00 | |
| 113_L | 284_L | 2.601 | 1.00 | |
| 202_Q | 266_T | 2.6 | 1.00 | |
| 45_V | 122_I | 2.475 | 1.00 | |
| 113_L | 286_T | 2.416 | 1.00 | |
| 409_L | 414_G | 2.371 | 1.00 | |
| 200_E | 204_A | 2.368 | 1.00 | |
| 339_L | 383_V | 2.339 | 1.00 | |
| 20_G | 403_T | 2.33 | 1.00 | |
| 303_S | 330_A | 2.303 | 1.00 | |
| 253_Y | 270_A | 2.262 | 1.00 | |
| 223_K | 239_V | 2.239 | 1.00 | |
| 218_S | 246_G | 2.216 | 1.00 | |
| 21_L | 51_R | 2.205 | 1.00 | |
| 55_P | 58_V | 2.132 | 1.00 | |
| 280_A | 399_A | 2.132 | 1.00 | |
| 243_N | 274_P | 2.131 | 1.00 | |
| 332_L | 416_F | 2.079 | 1.00 | |
| 223_K | 240_E | 2.077 | 1.00 | |
| 285_M | 290_A | 2.074 | 1.00 | |
| 217_W | 244_I | 2.073 | 1.00 | |
| 303_S | 326_A | 2.054 | 1.00 | |
| 109_V | 121_G | 2.036 | 1.00 | |
| 298_L | 410_R | 2.027 | 1.00 | |
| 338_T | 414_G | 2.024 | 1.00 | |
| 198_T | 201_Q | 1.98 | 1.00 | |
| 120_A | 285_M | 1.979 | 1.00 | |
| 43_M | 229_A | 1.964 | 1.00 | |
| 41_G | 64_F | 1.958 | 1.00 | |
| 41_G | 80_I | 1.936 | 1.00 | |
| 323_T | 420_T | 1.884 | 1.00 | |
| 193_K | 262_R | 1.882 | 1.00 | |
| 18_V | 285_M | 1.875 | 1.00 | |
| 299_G | 406_L | 1.869 | 1.00 | |
| 185_G | 260_F | 1.852 | 1.00 | |
| 384_L | 408_E | 1.841 | 1.00 | |
| 217_W | 226_V | 1.836 | 1.00 | |
| 332_L | 337_L | 1.82 | 1.00 | |
| 13_D | 288_S | 1.815 | 1.00 | |
| 31_A | 238_L | 1.812 | 1.00 | |
| 410_R | 435_A | 1.807 | 1.00 | |
| 214_A | 218_S | 1.79 | 1.00 | |
| 337_L | 416_F | 1.784 | 1.00 | |
| 214_A | 244_I | 1.761 | 1.00 | |
| 109_V | 284_L | 1.76 | 1.00 | |
| 45_V | 80_I | 1.753 | 1.00 | |
| 408_E | 412_R | 1.728 | 1.00 | |
| 58_V | 293_L | 1.722 | 1.00 | |
| 310_D | 313_Q | 1.695 | 1.00 | |
| 208_R | 378_D | 1.691 | 1.00 | |
| 337_L | 340_I | 1.674 | 1.00 | |
| 413_G | 435_A | 1.669 | 1.00 | |
| 48_L | 52_S | 1.665 | 1.00 | |
| 377_D | 380_K | 1.659 | 1.00 | |
| 324_P | 328_E | 1.656 | 1.00 | |
| 47_E | 227_M | 1.648 | 1.00 | |
| 252_D | 255_K | 1.642 | 1.00 | |
| 204_A | 208_R | 1.641 | 1.00 | |
| 217_W | 240_E | 1.62 | 1.00 | |
| 64_F | 124_G | 1.59 | 1.00 | |
| 300_Y | 434_E | 1.589 | 1.00 | |
| 119_R | 286_T | 1.585 | 1.00 | |
| 191_M | 197_I | 1.582 | 1.00 | |
| 334_M | 340_I | 1.577 | 1.00 | |
| 119_R | 289_R | 1.568 | 1.00 | |
| 43_M | 227_M | 1.567 | 1.00 | |
| 337_L | 432_V | 1.565 | 1.00 | |
| 282_V | 399_A | 1.564 | 1.00 | |
| 201_Q | 204_A | 1.563 | 1.00 | |
| 285_M | 289_R | 1.549 | 1.00 | |
| 221_K | 408_E | 1.533 | 1.00 | |
| 19_S | 48_L | 1.522 | 1.00 | |
| 207_H | 211_Q | 1.515 | 1.00 | |
| 332_L | 432_V | 1.514 | 1.00 | |
| 339_L | 408_E | 1.51 | 1.00 | |
| 47_E | 51_R | 1.508 | 1.00 | |
| 221_K | 384_L | 1.505 | 1.00 | |
| 93_Y | 108_N | 1.505 | 1.00 | |
| 408_E | 411_R | 1.491 | 1.00 | |
| 354_I | 381_F | 1.483 | 1.00 | |
| 286_T | 289_R | 1.47 | 1.00 | |
| 112_S | 118_I | 1.469 | 1.00 | |
| 418_L | 432_V | 1.468 | 1.00 | |
| 128_S | 131_V | 1.46 | 1.00 | |
| 354_I | 378_D | 1.459 | 1.00 | |
| 46_G | 50_A | 1.422 | 1.00 | |
| 19_S | 52_S | 1.42 | 1.00 | |
| 62_L | 81_V | 1.408 | 1.00 | |
| 340_I | 418_L | 1.408 | 1.00 | |
| 14_R | 300_Y | 1.406 | 0.99 | |
| 324_P | 356_L | 1.396 | 0.99 | |
| 100_A | 429_A | 1.395 | 0.99 | |
| 406_L | 410_R | 1.394 | 0.99 | |
| 224_E | 410_R | 1.391 | 0.99 | |
| 44_V | 281_A | 1.387 | 0.99 | |
| 248_S | 253_Y | 1.381 | 0.99 | |
| 415_G | 434_E | 1.372 | 0.99 | |
| 322_S | 430_A | 1.368 | 0.99 | |
| 32_F | 238_L | 1.364 | 0.99 | |
| 106_V | 282_V | 1.363 | 0.99 | |
| 25_F | 390_Y | 1.358 | 0.99 | |
| 211_Q | 247_N | 1.351 | 0.99 | |
| 15_I | 284_L | 1.348 | 0.99 | |
| 383_V | 412_R | 1.347 | 0.99 | |
| 25_F | 396_A | 1.341 | 0.99 | |
| 305_A | 326_A | 1.339 | 0.99 | |
| 309_I | 317_L | 1.335 | 0.99 | |
| 103_F | 402_I | 1.33 | 0.99 | |
| 230_F | 237_P | 1.329 | 0.99 | |
| 39_D | 83_G | 1.324 | 0.99 | |
| 333_T | 336_D | 1.323 | 0.99 | |
| 88_V | 310_D | 1.321 | 0.99 | |
| 338_T | 409_L | 1.319 | 0.99 | |
| 66_Q | 69_Q | 1.31 | 0.99 | |
| 16_A | 300_Y | 1.309 | 0.99 | |
| 321_W | 324_P | 1.309 | 0.99 | |
| 122_I | 283_I | 1.308 | 0.99 | |
| 403_T | 407_H | 1.299 | 0.99 | |
| 405_T | 419_V | 1.298 | 0.99 | |
| 327_L | 334_M | 1.297 | 0.99 | |
| 76_I | 126_A | 1.297 | 0.99 | |
| 383_V | 408_E | 1.295 | 0.99 | |
| 214_A | 247_N | 1.295 | 0.99 | |
| 64_F | 281_A | 1.291 | 0.99 | |
| 194_T | 314_D | 1.29 | 0.99 | |
| 325_L | 328_E | 1.269 | 0.99 | |
| 16_A | 287_E | 1.268 | 0.99 | |
| 111_E | 117_T | 1.268 | 0.99 | |
| 60_E | 119_R | 1.243 | 0.98 | |
| 197_I | 351_L | 1.232 | 0.98 | |
| 301_L | 431_M | 1.23 | 0.98 | |
| 402_I | 433_L | 1.229 | 0.98 | |
| 364_R | 367_L | 1.225 | 0.98 | |
| 60_E | 118_I | 1.216 | 0.98 | |
| 107_A | 431_M | 1.215 | 0.98 | |
| 100_A | 423_A | 1.215 | 0.98 | |
| 20_G | 407_H | 1.214 | 0.98 | |
| 109_V | 123_A | 1.214 | 0.98 | |
| 21_L | 227_M | 1.209 | 0.98 | |
| 211_Q | 215_Q | 1.206 | 0.98 | |
| 42_K | 83_G | 1.203 | 0.98 | |
| 49_L | 54_I | 1.2 | 0.98 | |
| 204_A | 250_L | 1.18 | 0.98 | |
| 59_I | 120_A | 1.18 | 0.98 | |
| 317_L | 320_A | 1.179 | 0.98 | |
| 338_T | 380_K | 1.179 | 0.98 | |
| 16_A | 285_M | 1.179 | 0.98 | |
| 339_L | 412_R | 1.17 | 0.97 | |
| 19_S | 51_R | 1.167 | 0.97 | |
| 120_A | 289_R | 1.165 | 0.97 | |
| 197_I | 202_Q | 1.153 | 0.97 | |
| 23_T | 44_V | 1.15 | 0.97 | |
| 305_A | 325_L | 1.15 | 0.97 | |
| 63_V | 121_G | 1.139 | 0.97 | |
| 205_L | 350_T | 1.135 | 0.97 | |
| 208_R | 379_S | 1.134 | 0.97 | |
| 330_A | 432_V | 1.129 | 0.97 | |
| 106_V | 284_L | 1.128 | 0.97 | |
| 303_S | 329_R | 1.127 | 0.97 | |
| 24_P | 238_L | 1.118 | 0.96 | |
| 288_S | 292_E | 1.114 | 0.96 | |
| 221_K | 411_R | 1.106 | 0.96 | |
| 207_H | 247_N | 1.106 | 0.96 | |
| 107_A | 304_Y | 1.101 | 0.96 | |
| 303_S | 432_V | 1.1 | 0.96 | |
| 44_V | 279_A | 1.098 | 0.96 | |
| 49_L | 86_M | 1.097 | 0.96 | |
| 104_Q | 108_N | 1.094 | 0.96 | |
| 400_R | 404_Q | 1.092 | 0.96 | |
| 17_I | 433_L | 1.091 | 0.96 | |
| 317_L | 356_L | 1.089 | 0.96 | |
| 337_L | 418_L | 1.088 | 0.96 | |
| 215_Q | 218_S | 1.081 | 0.95 | |
| 323_T | 418_L | 1.08 | 0.95 | |
| 342_M | 420_T | 1.079 | 0.95 | |
| 250_L | 254_A | 1.078 | 0.95 | |
| 225_E | 404_Q | 1.076 | 0.95 | |
| 45_V | 86_M | 1.073 | 0.95 | |
| 194_T | 313_Q | 1.072 | 0.95 | |
| 44_V | 47_E | 1.071 | 0.95 | |
| 323_T | 342_M | 1.069 | 0.95 | |
| 307_T | 321_W | 1.069 | 0.95 | |
| 207_H | 253_Y | 1.069 | 0.95 | |
| 185_G | 259_A | 1.064 | 0.95 | |
| 36_P | 39_D | 1.06 | 0.95 | |
| 314_D | 317_L | 1.055 | 0.95 | |
| 302_R | 434_E | 1.041 | 0.94 | |
| 302_R | 416_F | 1.036 | 0.94 | |
| 18_V | 295_L | 1.035 | 0.94 | |
| 44_V | 48_L | 1.031 | 0.94 | |
| 35_I | 43_M | 1.031 | 0.94 | |
| 224_E | 411_R | 1.026 | 0.94 | |
| 320_A | 324_P | 1.025 | 0.93 | |
| 401_M | 419_V | 1.025 | 0.93 | |
| 26_A | 242_N | 1.014 | 0.93 | |
| 224_E | 407_H | 1.014 | 0.93 | |
| 217_W | 223_K | 1.014 | 0.93 | |
| 15_I | 286_T | 1.013 | 0.93 | |
| 211_Q | 214_A | 1.009 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2wu9A | 2 | 0.8945 | 100 | 0.286 | Contact Map | 0.814 |
| 2vu1A | 4 | 0.8945 | 100 | 0.288 | Contact Map | 0.825 |
| 4dd5A | 1 | 0.9037 | 100 | 0.289 | Contact Map | 0.831 |
| 1ulqA | 8 | 0.9106 | 100 | 0.29 | Contact Map | 0.85 |
| 4e1lA | 4 | 0.8991 | 100 | 0.294 | Contact Map | 0.875 |
| 3ss6A | 2 | 0.8991 | 100 | 0.297 | Contact Map | 0.822 |
| 1wdkC | 2 | 0.8784 | 100 | 0.304 | Contact Map | 0.791 |
| 1wl4A | 1 | 0.9037 | 100 | 0.307 | Contact Map | 0.834 |
| 2iikA | 2 | 0.8945 | 100 | 0.309 | Contact Map | 0.815 |
| 3goaA | 2 | 0.8716 | 100 | 0.309 | Contact Map | 0.838 |
Sequence Conservation (Image Generated using WebLogo v3)