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YGCU - Uncharacterized FAD-linked oxidoreductase YgcU
UniProt: Q46911 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13128
Length: 484 (462)
Sequences: 4216
Seq/Len: 9.13
YGCU
Paralog alert: 0.68 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: DLD GLCD GLCE YGCU
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
156_V 219_V 5.482 1.00
74_K 471_N 4.534 1.00
71_N 471_N 4.446 1.00
240_D 243_T 4.034 1.00
358_C 361_E 3.95 1.00
67_L 77_G 3.824 1.00
121_Q 218_E 3.795 1.00
157_A 209_N 3.782 1.00
11_Q 72_A 3.678 1.00
100_L 215_Y 3.493 1.00
112_D 115_N 3.471 1.00
180_A 206_I 3.431 1.00
365_S 431_R 3.424 1.00
107_Q 121_Q 3.37 1.00
60_T 179_E 3.151 1.00
242_K 364_E 3.12 1.00
179_E 218_E 3.052 1.00
427_E 452_L 2.967 1.00
206_I 214_C 2.957 1.00
118_A 221_V 2.86 1.00
64_S 187_V 2.715 1.00
373_E 424_I 2.669 1.00
118_A 129_L 2.62 1.00
60_T 187_V 2.603 1.00
55_V 66_V 2.512 1.00
124_V 129_L 2.46 1.00
138_Y 223_I 2.446 1.00
113_I 136_K 2.416 1.00
24_D 27_V 2.413 1.00
58_G 62_Q 2.406 1.00
444_K 478_T 2.342 1.00
108_I 124_V 2.334 1.00
183_A 474_M 2.311 1.00
58_G 104_A 2.295 1.00
109_I 121_Q 2.284 1.00
110_N 119_T 2.272 1.00
156_V 216_I 2.271 1.00
180_A 214_C 2.253 1.00
61_E 65_R 2.217 1.00
80_R 83_A 2.193 1.00
67_L 71_N 2.174 1.00
132_A 135_E 2.173 1.00
102_G 215_Y 2.166 1.00
15_I 69_F 2.129 1.00
55_V 98_V 2.118 1.00
111_I 132_A 2.103 1.00
128_V 131_N 2.095 1.00
70_M 98_V 2.082 1.00
200_P 212_A 2.082 1.00
119_T 218_E 2.068 1.00
179_E 189_R 2.065 1.00
125_P 128_V 2.025 1.00
67_L 215_Y 2.02 1.00
127_E 131_N 2.015 1.00
20_R 62_Q 2.014 1.00
11_Q 73_H 2.01 1.00
21_V 55_V 2.008 1.00
8_I 69_F 1.952 1.00
150_A 155_L 1.941 1.00
13_K 18_A 1.924 1.00
183_A 468_F 1.912 1.00
242_K 361_E 1.901 1.00
60_T 64_S 1.899 1.00
365_S 428_E 1.893 1.00
16_V 55_V 1.843 1.00
69_F 73_H 1.825 1.00
65_R 68_N 1.822 1.00
67_L 474_M 1.81 1.00
60_T 217_T 1.799 1.00
119_T 220_T 1.796 1.00
353_S 435_S 1.795 1.00
22_I 27_V 1.791 1.00
112_D 117_Q 1.779 1.00
427_E 431_R 1.772 1.00
69_F 75_I 1.763 1.00
365_S 432_L 1.726 1.00
242_K 246_N 1.726 1.00
63_V 217_T 1.721 1.00
66_V 100_L 1.71 1.00
463_G 467_Q 1.707 1.00
116_M 138_Y 1.706 1.00
250_E 307_R 1.702 1.00
157_A 216_I 1.701 1.00
17_G 20_R 1.694 1.00
243_T 246_N 1.692 1.00
54_V 99_V 1.686 1.00
57_L 62_Q 1.685 1.00
460_L 463_G 1.684 1.00
109_I 218_E 1.68 1.00
437_V 442_I 1.678 1.00
16_V 20_R 1.676 1.00
179_E 217_T 1.672 1.00
451_K 456_S 1.641 1.00
120_A 152_M 1.64 1.00
238_L 247_I 1.632 1.00
182_L 186_T 1.603 1.00
239_E 243_T 1.603 1.00
59_S 62_Q 1.6 1.00
190_I 203_R 1.594 1.00
115_N 357_S 1.586 1.00
79_P 215_Y 1.582 1.00
15_I 65_R 1.579 1.00
361_E 432_L 1.574 1.00
181_V 187_V 1.562 1.00
108_I 132_A 1.553 1.00
141_G 174_M 1.551 1.00
20_R 58_G 1.546 1.00
106_N 128_V 1.509 1.00
68_N 72_A 1.475 1.00
428_E 431_R 1.459 1.00
77_G 100_L 1.459 1.00
57_L 66_V 1.458 1.00
362_I 432_L 1.455 1.00
22_I 56_K 1.446 1.00
361_E 365_S 1.444 1.00
412_E 415_D 1.436 0.99
152_M 219_V 1.434 0.99
205_I 464_L 1.433 0.99
459_A 462_E 1.431 0.99
9_V 13_K 1.427 0.99
25_E 28_L 1.426 0.99
133_L 223_I 1.419 0.99
475_N 478_T 1.412 0.99
56_K 104_A 1.409 0.99
81_T 151_Q 1.405 0.99
302_A 306_A 1.384 0.99
299_E 302_A 1.376 0.99
12_L 55_V 1.368 0.99
134_R 227_T 1.36 0.99
102_G 105_M 1.357 0.99
186_T 459_A 1.346 0.99
122_C 219_V 1.346 0.99
23_T 53_A 1.344 0.99
22_I 31_N 1.328 0.99
64_S 68_N 1.327 0.99
175_V 207_I 1.301 0.99
11_Q 69_F 1.291 0.99
11_Q 14_E 1.29 0.99
289_G 294_A 1.282 0.99
53_A 98_V 1.275 0.98
76_N 97_S 1.269 0.98
442_I 450_S 1.269 0.98
10_D 13_K 1.268 0.98
374_F 424_I 1.258 0.98
177_G 192_N 1.255 0.98
459_A 463_G 1.255 0.98
77_G 473_I 1.254 0.98
303_E 307_R 1.25 0.98
111_I 118_A 1.248 0.98
71_N 473_I 1.239 0.98
63_V 215_Y 1.236 0.98
369_R 373_E 1.233 0.98
10_D 14_E 1.223 0.98
9_V 53_A 1.212 0.98
16_V 66_V 1.209 0.98
21_V 53_A 1.201 0.98
8_I 75_I 1.198 0.97
179_E 187_V 1.198 0.97
129_L 221_V 1.196 0.97
63_V 100_L 1.193 0.97
13_K 21_V 1.191 0.97
460_L 468_F 1.19 0.97
75_I 473_I 1.186 0.97
103_S 151_Q 1.183 0.97
198_A 437_V 1.18 0.97
423_K 427_E 1.18 0.97
410_P 413_E 1.175 0.97
64_S 181_V 1.173 0.97
15_I 66_V 1.173 0.97
60_T 105_M 1.171 0.97
61_E 64_S 1.167 0.97
60_T 63_V 1.165 0.97
355_C 358_C 1.147 0.96
52_A 97_S 1.145 0.96
130_E 133_L 1.144 0.96
415_D 420_P 1.14 0.96
412_E 416_K 1.138 0.96
365_S 369_R 1.13 0.96
85_A 89_G 1.125 0.96
24_D 28_L 1.124 0.96
64_S 67_L 1.117 0.96
70_M 77_G 1.115 0.96
358_C 432_L 1.114 0.96
206_I 216_I 1.114 0.96
174_M 224_F 1.11 0.96
156_V 171_I 1.105 0.95
117_Q 220_T 1.103 0.95
11_Q 15_I 1.089 0.95
142_H 174_M 1.087 0.95
300_G 303_E 1.082 0.95
63_V 102_G 1.081 0.95
60_T 181_V 1.079 0.95
459_A 466_K 1.079 0.95
291_P 295_K 1.079 0.95
127_E 147_K 1.068 0.94
8_I 12_L 1.066 0.94
177_G 189_R 1.063 0.94
78_V 97_S 1.055 0.94
100_L 474_M 1.054 0.94
201_D 204_H 1.051 0.94
209_N 213_L 1.046 0.93
110_N 117_Q 1.038 0.93
102_G 122_C 1.037 0.93
132_A 136_K 1.034 0.93
216_I 219_V 1.034 0.93
126_L 150_A 1.033 0.93
298_G 302_A 1.03 0.93
335_A 339_Q 1.028 0.93
465_K 469_D 1.027 0.92
349_T 400_V 1.016 0.92
466_K 472_G 1.015 0.92
156_V 175_V 1.014 0.92
130_E 139_T 1.014 0.92
85_A 90_L 1.013 0.92
131_N 135_E 1.012 0.92
20_R 104_A 1.009 0.92
126_L 155_L 1.007 0.91
31_N 54_V 1.007 0.91
177_G 220_T 1.006 0.91
62_Q 66_V 1.006 0.91
57_L 102_G 1.002 0.91
71_N 74_K 1.002 0.91
189_R 218_E 1.001 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2uuuA40.91941000.208Contact Map0.771
3pm9A60.92561000.265Contact Map0.823
4bbyA40.96691000.27Contact Map0.695
1f0xA20.89461000.289Contact Map0.545
1wvfA10.94011000.297Contact Map0.696
2exrA10.85741000.347Contact Map0.522
1e8gA20.92151000.353Contact Map0.681
1w1oA10.85951000.364Contact Map0.65
4fehA10.79341000.53Contact Map0.638
3w8zA20.89881000.61Contact Map0.691
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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