| UniProt: | P0AEP9 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12997 | ||
| Length: | 499 (456) | ||
| Sequences: | 5033 | ||
| Seq/Len: | 11.04 |
| GLCD
Paralog alert: 0.82 [within 20: 0.09] - ratio of genomes with paralogs Cluster includes: DLD GLCD GLCE YGCU |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 160_V | 223_V | 4.978 | 1.00 | |
| 76_H | 463_D | 4.332 | 1.00 | |
| 79_R | 463_D | 4.33 | 1.00 | |
| 362_A | 365_G | 3.866 | 1.00 | |
| 72_L | 82_V | 3.654 | 1.00 | |
| 243_S | 246_K | 3.635 | 1.00 | |
| 24_A | 77_R | 3.543 | 1.00 | |
| 125_Q | 222_E | 3.493 | 1.00 | |
| 65_M | 183_E | 3.465 | 1.00 | |
| 116_N | 119_G | 3.356 | 1.00 | |
| 104_L | 219_V | 3.275 | 1.00 | |
| 184_V | 210_F | 3.195 | 1.00 | |
| 369_G | 422_E | 3.186 | 1.00 | |
| 161_A | 213_S | 3.164 | 1.00 | |
| 183_E | 222_E | 3.157 | 1.00 | |
| 111_E | 125_Q | 3.152 | 1.00 | |
| 245_E | 368_E | 3.061 | 1.00 | |
| 122_A | 225_V | 2.725 | 1.00 | |
| 60_V | 71_I | 2.612 | 1.00 | |
| 376_Q | 415_K | 2.608 | 1.00 | |
| 63_K | 108_R | 2.597 | 1.00 | |
| 69_T | 191_A | 2.575 | 1.00 | |
| 210_F | 218_G | 2.554 | 1.00 | |
| 122_A | 133_I | 2.532 | 1.00 | |
| 63_K | 67_Q | 2.498 | 1.00 | |
| 142_L | 227_L | 2.495 | 1.00 | |
| 418_E | 443_A | 2.489 | 1.00 | |
| 128_V | 133_I | 2.444 | 1.00 | |
| 65_M | 191_A | 2.417 | 1.00 | |
| 117_P | 140_H | 2.404 | 1.00 | |
| 113_L | 125_Q | 2.389 | 1.00 | |
| 136_A | 139_P | 2.331 | 1.00 | |
| 123_R | 224_T | 2.298 | 1.00 | |
| 183_E | 193_T | 2.289 | 1.00 | |
| 123_R | 222_E | 2.252 | 1.00 | |
| 37_T | 40_E | 2.206 | 1.00 | |
| 112_I | 128_V | 2.204 | 1.00 | |
| 60_V | 102_V | 2.195 | 1.00 | |
| 115_I | 136_A | 2.166 | 1.00 | |
| 187_L | 466_L | 2.105 | 1.00 | |
| 65_M | 69_T | 2.062 | 1.00 | |
| 66_E | 70_A | 2.042 | 1.00 | |
| 106_M | 219_V | 2.042 | 1.00 | |
| 114_D | 123_R | 2.022 | 1.00 | |
| 184_V | 218_G | 2.021 | 1.00 | |
| 85_R | 88_G | 2.013 | 1.00 | |
| 72_L | 76_H | 2.013 | 1.00 | |
| 442_C | 447_S | 2.007 | 1.00 | |
| 131_L | 135_Q | 1.977 | 1.00 | |
| 129_R | 132_A | 1.963 | 1.00 | |
| 435_R | 470_K | 1.938 | 1.00 | |
| 68_V | 221_T | 1.917 | 1.00 | |
| 183_E | 221_T | 1.909 | 1.00 | |
| 33_E | 67_Q | 1.901 | 1.00 | |
| 75_C | 102_V | 1.878 | 1.00 | |
| 26_R | 31_G | 1.873 | 1.00 | |
| 110_K | 132_A | 1.871 | 1.00 | |
| 28_H | 74_V | 1.871 | 1.00 | |
| 24_A | 78_L | 1.852 | 1.00 | |
| 369_G | 419_L | 1.845 | 1.00 | |
| 116_N | 121_R | 1.835 | 1.00 | |
| 132_A | 135_Q | 1.83 | 1.00 | |
| 72_L | 219_V | 1.829 | 1.00 | |
| 72_L | 466_L | 1.828 | 1.00 | |
| 138_A | 230_K | 1.827 | 1.00 | |
| 186_T | 190_E | 1.821 | 1.00 | |
| 74_V | 78_L | 1.811 | 1.00 | |
| 418_E | 422_E | 1.777 | 1.00 | |
| 65_M | 221_T | 1.761 | 1.00 | |
| 160_V | 220_T | 1.75 | 1.00 | |
| 113_L | 222_E | 1.739 | 1.00 | |
| 154_C | 159_N | 1.73 | 1.00 | |
| 369_G | 423_V | 1.728 | 1.00 | |
| 70_A | 73_A | 1.722 | 1.00 | |
| 74_V | 80_V | 1.707 | 1.00 | |
| 369_G | 372_R | 1.706 | 1.00 | |
| 21_V | 74_V | 1.706 | 1.00 | |
| 84_T | 219_V | 1.701 | 1.00 | |
| 455_A | 459_A | 1.686 | 1.00 | |
| 29_V | 60_V | 1.68 | 1.00 | |
| 137_V | 227_L | 1.663 | 1.00 | |
| 161_A | 220_T | 1.661 | 1.00 | |
| 402_E | 405_E | 1.628 | 1.00 | |
| 124_V | 156_I | 1.628 | 1.00 | |
| 64_Q | 67_Q | 1.627 | 1.00 | |
| 62_P | 67_Q | 1.622 | 1.00 | |
| 187_L | 460_F | 1.62 | 1.00 | |
| 245_E | 365_G | 1.604 | 1.00 | |
| 377_Y | 415_K | 1.604 | 1.00 | |
| 30_P | 33_E | 1.596 | 1.00 | |
| 71_I | 104_L | 1.594 | 1.00 | |
| 34_I | 60_V | 1.588 | 1.00 | |
| 245_E | 249_L | 1.582 | 1.00 | |
| 120_R | 142_L | 1.574 | 1.00 | |
| 194_L | 207_L | 1.571 | 1.00 | |
| 241_F | 250_A | 1.563 | 1.00 | |
| 35_L | 40_E | 1.562 | 1.00 | |
| 185_Q | 191_A | 1.537 | 1.00 | |
| 68_V | 104_L | 1.53 | 1.00 | |
| 407_A | 411_E | 1.528 | 1.00 | |
| 204_F | 216_M | 1.514 | 1.00 | |
| 253_D | 316_A | 1.51 | 1.00 | |
| 246_K | 249_L | 1.497 | 1.00 | |
| 365_G | 369_G | 1.491 | 1.00 | |
| 357_T | 426_S | 1.483 | 1.00 | |
| 359_P | 362_A | 1.477 | 1.00 | |
| 23_M | 26_R | 1.466 | 1.00 | |
| 242_D | 246_K | 1.466 | 1.00 | |
| 365_G | 423_V | 1.466 | 1.00 | |
| 428_S | 433_I | 1.45 | 1.00 | |
| 366_V | 423_V | 1.446 | 1.00 | |
| 33_E | 63_K | 1.438 | 1.00 | |
| 145_A | 178_N | 1.436 | 1.00 | |
| 307_E | 311_D | 1.434 | 1.00 | |
| 73_A | 77_R | 1.431 | 1.00 | |
| 61_L | 108_R | 1.428 | 1.00 | |
| 180_L | 226_K | 1.426 | 1.00 | |
| 372_R | 376_Q | 1.418 | 1.00 | |
| 86_G | 155_S | 1.414 | 1.00 | |
| 38_D | 41_I | 1.41 | 1.00 | |
| 452_T | 455_A | 1.407 | 0.99 | |
| 59_V | 103_L | 1.394 | 0.99 | |
| 112_I | 136_A | 1.392 | 0.99 | |
| 35_L | 44_Y | 1.386 | 0.99 | |
| 451_T | 455_A | 1.383 | 0.99 | |
| 404_G | 407_A | 1.376 | 0.99 | |
| 24_A | 27_E | 1.376 | 0.99 | |
| 82_V | 104_L | 1.367 | 0.99 | |
| 373_L | 419_L | 1.355 | 0.99 | |
| 253_D | 315_K | 1.34 | 0.99 | |
| 183_E | 191_A | 1.339 | 0.99 | |
| 310_N | 314_L | 1.336 | 0.99 | |
| 419_L | 422_E | 1.326 | 0.99 | |
| 69_T | 185_Q | 1.326 | 0.99 | |
| 28_H | 70_A | 1.321 | 0.99 | |
| 451_T | 454_H | 1.318 | 0.99 | |
| 119_G | 361_R | 1.317 | 0.99 | |
| 446_N | 449_E | 1.315 | 0.99 | |
| 29_V | 33_E | 1.305 | 0.99 | |
| 22_L | 26_R | 1.303 | 0.99 | |
| 25_L | 60_V | 1.295 | 0.99 | |
| 69_T | 73_A | 1.285 | 0.99 | |
| 66_E | 69_T | 1.281 | 0.99 | |
| 111_E | 128_V | 1.274 | 0.99 | |
| 303_Q | 307_E | 1.273 | 0.99 | |
| 181_K | 193_T | 1.259 | 0.99 | |
| 76_H | 465_L | 1.258 | 0.99 | |
| 62_P | 71_I | 1.25 | 0.99 | |
| 373_L | 415_K | 1.246 | 0.98 | |
| 36_H | 58_L | 1.243 | 0.98 | |
| 307_E | 310_N | 1.232 | 0.98 | |
| 335_A | 339_N | 1.229 | 0.98 | |
| 250_A | 313_L | 1.224 | 0.98 | |
| 23_M | 27_E | 1.224 | 0.98 | |
| 35_L | 61_L | 1.223 | 0.98 | |
| 126_P | 223_V | 1.218 | 0.98 | |
| 106_M | 109_F | 1.216 | 0.98 | |
| 37_T | 41_I | 1.21 | 0.98 | |
| 68_V | 185_Q | 1.207 | 0.98 | |
| 414_G | 418_E | 1.204 | 0.98 | |
| 372_R | 375_Q | 1.203 | 0.98 | |
| 209_L | 456_V | 1.203 | 0.98 | |
| 29_V | 71_I | 1.198 | 0.98 | |
| 269_N | 288_E | 1.197 | 0.98 | |
| 26_R | 34_I | 1.195 | 0.98 | |
| 72_L | 185_Q | 1.194 | 0.98 | |
| 447_S | 451_T | 1.185 | 0.98 | |
| 107_A | 155_S | 1.176 | 0.98 | |
| 327_E | 331_V | 1.171 | 0.98 | |
| 179_L | 211_T | 1.17 | 0.97 | |
| 308_R | 311_D | 1.158 | 0.97 | |
| 326_D | 329_E | 1.153 | 0.97 | |
| 467_N | 470_K | 1.153 | 0.97 | |
| 24_A | 74_V | 1.152 | 0.97 | |
| 121_R | 224_T | 1.151 | 0.97 | |
| 213_S | 217_L | 1.149 | 0.97 | |
| 22_L | 58_L | 1.148 | 0.97 | |
| 58_L | 102_V | 1.146 | 0.97 | |
| 156_I | 223_V | 1.144 | 0.97 | |
| 131_L | 151_Q | 1.141 | 0.97 | |
| 24_A | 28_H | 1.135 | 0.97 | |
| 451_T | 458_A | 1.132 | 0.97 | |
| 190_E | 448_D | 1.131 | 0.97 | |
| 371_A | 375_Q | 1.13 | 0.97 | |
| 82_V | 465_L | 1.13 | 0.97 | |
| 81_P | 101_G | 1.13 | 0.97 | |
| 297_G | 302_V | 1.127 | 0.97 | |
| 115_I | 122_A | 1.124 | 0.97 | |
| 181_K | 224_T | 1.122 | 0.97 | |
| 239_A | 293_C | 1.121 | 0.97 | |
| 292_L | 333_F | 1.119 | 0.96 | |
| 41_I | 45_E | 1.119 | 0.96 | |
| 28_H | 71_I | 1.116 | 0.96 | |
| 68_V | 219_V | 1.107 | 0.96 | |
| 190_E | 451_T | 1.107 | 0.96 | |
| 311_D | 315_K | 1.105 | 0.96 | |
| 135_Q | 139_P | 1.095 | 0.96 | |
| 235_R | 303_Q | 1.093 | 0.96 | |
| 246_K | 317_G | 1.086 | 0.96 | |
| 311_D | 314_L | 1.082 | 0.96 | |
| 109_F | 125_Q | 1.082 | 0.96 | |
| 65_M | 109_F | 1.075 | 0.95 | |
| 362_A | 423_V | 1.073 | 0.95 | |
| 303_Q | 325_Q | 1.073 | 0.95 | |
| 377_Y | 411_E | 1.07 | 0.95 | |
| 404_G | 408_R | 1.066 | 0.95 | |
| 136_A | 140_H | 1.066 | 0.95 | |
| 193_T | 222_E | 1.065 | 0.95 | |
| 125_Q | 128_V | 1.063 | 0.95 | |
| 458_A | 464_G | 1.062 | 0.95 | |
| 134_S | 137_V | 1.052 | 0.95 | |
| 132_A | 136_A | 1.05 | 0.94 | |
| 85_R | 103_L | 1.045 | 0.94 | |
| 21_V | 80_V | 1.043 | 0.94 | |
| 44_Y | 59_V | 1.04 | 0.94 | |
| 35_L | 41_I | 1.036 | 0.94 | |
| 194_L | 210_F | 1.035 | 0.94 | |
| 269_N | 273_R | 1.035 | 0.94 | |
| 368_E | 372_R | 1.034 | 0.94 | |
| 21_V | 25_L | 1.024 | 0.93 | |
| 79_R | 465_L | 1.022 | 0.93 | |
| 124_V | 133_I | 1.02 | 0.93 | |
| 433_I | 441_M | 1.018 | 0.93 | |
| 130_N | 159_N | 1.015 | 0.93 | |
| 452_T | 460_F | 1.014 | 0.93 | |
| 90_G | 94_G | 1.012 | 0.93 | |
| 160_V | 179_L | 1.01 | 0.93 | |
| 271_S | 340_A | 1.009 | 0.93 | |
| 299_E | 303_Q | 1.007 | 0.93 | |
| 80_V | 465_L | 1.005 | 0.93 | |
| 254_I | 309_V | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3pm9A | 6 | 0.9339 | 100 | 0.259 | Contact Map | 0.821 |
| 2uuuA | 4 | 0.9319 | 100 | 0.276 | Contact Map | 0.76 |
| 1wvfA | 1 | 0.9339 | 100 | 0.316 | Contact Map | 0.702 |
| 1f0xA | 2 | 0.9038 | 100 | 0.316 | Contact Map | 0.527 |
| 4bbyA | 4 | 0.9319 | 100 | 0.334 | Contact Map | 0.692 |
| 1e8gA | 2 | 0.9419 | 100 | 0.36 | Contact Map | 0.682 |
| 2exrA | 1 | 0.8938 | 100 | 0.365 | Contact Map | 0.51 |
| 1w1oA | 1 | 0.8938 | 100 | 0.366 | Contact Map | 0.632 |
| 4fehA | 1 | 0.8878 | 100 | 0.486 | Contact Map | 0.663 |
| 3w8zA | 2 | 0.8697 | 100 | 0.56 | Contact Map | 0.682 |
Sequence Conservation (Image Generated using WebLogo v3)