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OPENSEQ.org
FADJ - Fatty acid oxidation complex subunit alpha
UniProt: P77399 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14127
Length: 714 (700)
Sequences: 1190
Seq/Len: 1.70
FADJ
Paralog alert: 0.71 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FADB FADJ PAAH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
342_P 346_N 4.741 1.00
679_Q 696_V 4.33 1.00
113_L 137_G 3.195 1.00
47_R 96_E 3.112 1.00
328_A 377_I 2.961 1.00
168_I 250_I 2.933 1.00
360_V 365_L 2.784 1.00
438_R 441_Q 2.696 1.00
367_A 371_D 2.573 1.00
153_Q 265_G 2.564 1.00
430_G 463_A 2.553 1.00
106_A 123_C 2.496 1.00
487_V 494_Y 2.484 1.00
128_C 185_V 2.482 1.00
392_I 414_C 2.446 1.00
261_G 264_S 2.425 1.00
311_V 391_L 2.355 1.00
457_V 477_A 2.324 1.00
310_S 388_H 2.246 0.99
405_Q 409_E 2.236 0.99
288_I 650_V 2.223 0.99
477_A 484_P 2.186 0.99
55_V 102_I 2.175 0.99
312_G 389_R 2.154 0.99
620_E 677_I 2.146 0.99
675_V 699_G 2.139 0.99
635_D 694_R 2.096 0.99
44_K 96_E 2.084 0.99
117_L 136_L 2.081 0.99
693_E 697_E 2.077 0.99
545_T 570_L 2.067 0.99
312_G 386_F 2.06 0.99
66_I 119_L 2.059 0.99
356_L 370_R 2.056 0.99
249_R 275_E 2.04 0.99
440_E 464_G 2.039 0.99
327_T 476_L 2.024 0.99
146_L 250_I 2.018 0.99
22_D 60_A 2.002 0.99
253_V 272_A 2.002 0.99
165_L 254_V 1.977 0.98
697_E 701_R 1.943 0.98
400_L 431_D 1.943 0.98
414_C 418_T 1.929 0.98
518_H 615_A 1.929 0.98
396_V 406_M 1.923 0.98
316_G 348_A 1.899 0.98
360_V 370_R 1.896 0.98
56_V 202_A 1.891 0.98
627_L 665_Y 1.888 0.98
630_A 663_F 1.876 0.97
542_D 578_K 1.876 0.97
128_C 136_L 1.863 0.97
94_M 122_A 1.828 0.97
694_R 705_F 1.813 0.97
282_S 286_R 1.811 0.97
356_L 373_Q 1.808 0.97
159_I 184_L 1.803 0.97
466_S 469_T 1.769 0.96
163_T 166_E 1.759 0.96
14_D 203_K 1.749 0.96
12_R 199_V 1.738 0.96
108_I 112_C 1.737 0.95
260_Q 268_A 1.73 0.95
46_L 55_V 1.72 0.95
407_V 420_F 1.71 0.95
417_H 441_Q 1.71 0.95
168_I 254_V 1.709 0.95
431_D 434_A 1.697 0.95
334_P 376_L 1.692 0.95
325_Y 355_Q 1.685 0.94
159_I 163_T 1.685 0.94
306_A 468_Q 1.674 0.94
95_A 99_A 1.664 0.94
614_S 617_Q 1.656 0.94
411_E 436_A 1.65 0.94
404_Q 435_H 1.641 0.93
37_S 41_A 1.634 0.93
311_V 327_T 1.632 0.93
371_D 375_A 1.628 0.93
189_V 197_A 1.614 0.93
135_V 173_Q 1.605 0.92
386_F 389_R 1.602 0.92
631_V 666_I 1.597 0.92
262_T 266_Y 1.594 0.92
64_N 111_A 1.59 0.92
649_A 662_P 1.586 0.92
35_F 39_V 1.581 0.92
470_I 486_V 1.577 0.91
445_L 477_A 1.573 0.91
391_L 476_L 1.564 0.91
523_L 622_C 1.564 0.91
672_G 676_A 1.559 0.91
679_Q 682_A 1.552 0.91
357_E 370_R 1.549 0.90
645_G 663_F 1.544 0.90
383_Y 413_N 1.535 0.90
372_K 376_L 1.529 0.90
159_I 167_M 1.528 0.90
54_G 202_A 1.525 0.90
677_I 680_R 1.524 0.90
159_I 182_L 1.522 0.89
155_L 184_L 1.517 0.89
494_Y 648_G 1.514 0.89
512_Q 621_R 1.502 0.89
510_L 519_I 1.5 0.89
616_P 620_E 1.494 0.88
522_A 615_A 1.494 0.88
20_T 60_A 1.487 0.88
20_T 58_V 1.487 0.88
353_W 357_E 1.482 0.88
136_L 184_L 1.476 0.87
46_L 52_L 1.463 0.87
16_I 56_V 1.459 0.87
17_A 55_V 1.453 0.86
508_R 511_T 1.449 0.86
455_P 483_T 1.448 0.86
548_I 567_S 1.444 0.86
694_R 698_M 1.443 0.86
330_K 373_Q 1.442 0.86
347_H 351_Y 1.438 0.86
370_R 374_L 1.432 0.85
536_L 544_G 1.427 0.85
117_L 184_L 1.416 0.84
505_E 512_Q 1.414 0.84
178_Q 182_L 1.413 0.84
634_V 645_G 1.413 0.84
255_E 259_A 1.412 0.84
138_L 155_L 1.402 0.84
642_V 667_D 1.398 0.83
599_P 603_P 1.396 0.83
494_Y 662_P 1.396 0.83
522_A 619_A 1.387 0.83
402_L 406_M 1.386 0.83
529_P 535_L 1.386 0.83
505_E 621_R 1.385 0.82
233_G 252_E 1.378 0.82
359_K 362_R 1.377 0.82
98_H 101_P 1.37 0.82
422_S 429_I 1.366 0.81
59_S 64_N 1.366 0.81
667_D 705_F 1.361 0.81
281_Q 284_A 1.361 0.81
104_V 124_H 1.357 0.81
165_L 232_V 1.355 0.81
85_A 89_Q 1.352 0.80
445_L 476_L 1.346 0.80
158_L 186_D 1.346 0.80
386_F 413_N 1.341 0.80
400_L 432_I 1.337 0.79
639_I 645_G 1.335 0.79
402_L 405_Q 1.33 0.79
632_R 635_D 1.327 0.79
312_G 336_R 1.326 0.79
499_L 535_L 1.318 0.78
338_K 409_E 1.304 0.77
359_K 364_H 1.301 0.77
545_T 571_N 1.3 0.77
141_V 250_I 1.3 0.77
412_Q 437_T 1.298 0.76
408_A 435_H 1.297 0.76
167_M 184_L 1.296 0.76
411_E 437_T 1.296 0.76
40_R 96_E 1.293 0.76
600_A 603_P 1.292 0.76
130_D 190_P 1.289 0.76
167_M 182_L 1.284 0.75
16_I 203_K 1.283 0.75
494_Y 649_A 1.279 0.75
345_I 381_T 1.279 0.75
675_V 695_L 1.276 0.75
21_I 66_I 1.275 0.75
127_V 187_D 1.275 0.75
345_I 348_A 1.272 0.74
396_V 402_L 1.271 0.74
628_N 692_C 1.27 0.74
122_A 154_R 1.268 0.74
675_V 696_V 1.268 0.74
52_L 55_V 1.266 0.74
545_T 567_S 1.265 0.74
55_V 100_L 1.258 0.73
367_A 370_R 1.252 0.73
378_S 385_G 1.251 0.73
146_L 253_V 1.251 0.73
21_I 35_F 1.248 0.72
74_I 277_A 1.247 0.72
312_G 380_T 1.245 0.72
459_I 474_V 1.242 0.72
585_L 598_D 1.24 0.72
231_M 234_K 1.239 0.72
152_T 265_G 1.239 0.72
146_L 276_L 1.231 0.71
432_I 442_V 1.231 0.71
98_H 301_S 1.229 0.71
462_H 465_T 1.228 0.71
419_I 472_T 1.224 0.70
574_R 598_D 1.222 0.70
87_A 90_G 1.221 0.70
627_L 666_I 1.221 0.70
445_L 473_T 1.221 0.70
245_P 281_Q 1.22 0.70
56_V 199_V 1.22 0.70
167_M 174_L 1.219 0.70
268_A 272_A 1.217 0.70
401_E 404_Q 1.216 0.70
117_L 120_A 1.213 0.69
514_E 518_H 1.208 0.69
623_V 659_L 1.204 0.68
525_K 615_A 1.204 0.68
380_T 385_G 1.203 0.68
319_M 493_F 1.203 0.68
520_D 597_V 1.203 0.68
415_A 418_T 1.202 0.68
17_A 364_H 1.197 0.68
485_I 648_G 1.192 0.67
56_V 195_L 1.19 0.67
98_H 102_I 1.188 0.67
356_L 452_E 1.184 0.67
249_R 276_L 1.184 0.67
156_P 159_I 1.183 0.66
85_A 88_R 1.183 0.66
342_P 381_T 1.183 0.66
494_Y 639_I 1.183 0.66
443_I 473_T 1.183 0.66
95_A 299_P 1.181 0.66
94_M 98_H 1.178 0.66
35_F 119_L 1.177 0.66
616_P 619_A 1.176 0.66
430_G 489_D 1.173 0.66
666_I 674_V 1.171 0.65
18_V 56_V 1.166 0.65
98_H 124_H 1.166 0.65
620_E 624_M 1.164 0.65
404_Q 431_D 1.163 0.65
673_E 676_A 1.161 0.64
98_H 299_P 1.156 0.64
12_R 18_V 1.156 0.64
490_K 638_V 1.156 0.64
52_L 102_I 1.155 0.64
105_I 127_V 1.149 0.63
495_V 639_I 1.148 0.63
236_T 240_T 1.148 0.63
43_I 97_I 1.145 0.63
383_Y 406_M 1.142 0.62
249_R 252_E 1.139 0.62
306_A 441_Q 1.137 0.62
414_C 417_H 1.134 0.62
47_R 100_L 1.132 0.61
108_I 195_L 1.132 0.61
310_S 336_R 1.131 0.61
605_I 610_Q 1.13 0.61
671_A 702_G 1.13 0.61
419_I 463_A 1.123 0.61
624_M 677_I 1.123 0.61
483_T 651_F 1.118 0.60
19_I 57_F 1.117 0.60
498_I 630_A 1.115 0.60
126_R 158_L 1.112 0.59
635_D 693_E 1.111 0.59
487_V 648_G 1.111 0.59
328_A 352_S 1.111 0.59
419_I 469_T 1.111 0.59
496_N 639_I 1.11 0.59
107_A 198_A 1.11 0.59
676_A 679_Q 1.11 0.59
100_L 153_Q 1.109 0.59
575_K 579_N 1.107 0.59
498_I 626_M 1.105 0.59
499_L 626_M 1.105 0.59
57_F 97_I 1.104 0.59
514_E 613_I 1.102 0.58
357_E 361_R 1.097 0.58
316_G 414_C 1.096 0.58
236_T 251_L 1.092 0.57
368_S 372_K 1.092 0.57
540_G 578_K 1.088 0.57
108_I 136_L 1.087 0.57
568_S 572_D 1.087 0.57
337_I 348_A 1.087 0.57
187_D 204_K 1.084 0.56
440_E 466_S 1.083 0.56
366_K 369_E 1.077 0.56
696_V 699_G 1.076 0.56
98_H 215_R 1.076 0.56
337_I 406_M 1.075 0.56
407_V 436_A 1.075 0.56
445_L 457_V 1.075 0.56
490_K 496_N 1.07 0.55
155_L 159_I 1.069 0.55
367_A 389_R 1.069 0.55
495_V 653_I 1.068 0.55
267_D 271_R 1.068 0.55
698_M 703_E 1.065 0.54
526_F 665_Y 1.063 0.54
461_P 467_A 1.063 0.54
244_Y 658_F 1.062 0.54
319_M 448_F 1.059 0.54
316_G 339_D 1.056 0.54
84_E 88_R 1.056 0.54
260_Q 264_S 1.056 0.54
153_Q 156_P 1.055 0.53
680_R 683_T 1.053 0.53
624_M 674_V 1.052 0.53
384_R 387_A 1.049 0.53
545_T 549_P 1.049 0.53
512_Q 613_I 1.047 0.53
71_I 143_L 1.045 0.52
196_E 200_E 1.045 0.52
461_P 640_R 1.045 0.52
620_E 665_Y 1.045 0.52
311_V 393_I 1.044 0.52
674_V 678_M 1.043 0.52
15_N 53_R 1.043 0.52
474_V 486_V 1.041 0.52
695_L 699_G 1.04 0.52
696_V 700_A 1.039 0.52
142_Q 173_Q 1.039 0.52
175_R 178_Q 1.039 0.52
101_P 124_H 1.039 0.52
95_A 101_P 1.038 0.52
112_C 134_T 1.035 0.51
101_P 301_S 1.034 0.51
135_V 175_R 1.034 0.51
581_R 585_L 1.032 0.51
639_I 663_F 1.031 0.51
514_E 519_I 1.031 0.51
424_T 493_F 1.028 0.51
325_Y 452_E 1.024 0.50
667_D 699_G 1.022 0.50
156_P 265_G 1.019 0.50
112_C 183_G 1.019 0.50
509_M 514_E 1.018 0.49
353_W 374_L 1.018 0.49
280_P 668_S 1.017 0.49
308_L 472_T 1.015 0.49
172_K 178_Q 1.015 0.49
230_K 255_E 1.015 0.49
276_L 279_T 1.014 0.49
675_V 679_Q 1.013 0.49
338_K 383_Y 1.012 0.49
101_P 299_P 1.01 0.49
174_L 182_L 1.009 0.49
391_L 445_L 1.009 0.49
526_F 627_L 1.008 0.48
299_P 640_R 1.007 0.48
95_A 98_H 1.007 0.48
423_N 493_F 1.006 0.48
423_N 448_F 1.005 0.48
448_F 454_M 1.005 0.48
704_S 707_K 1.004 0.48
125_G 201_L 1.004 0.48
400_L 427_L 1.003 0.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1wdkA20.98181000.28Contact Map0.743
2wtbA10.98321000.296Contact Map0.665
4b3hA20.9651000.299Contact Map0.716
3zwcA20.9651000.327Contact Map0.735
1zcjA10.6051000.568Contact Map0.719
3k6jA10.61621000.582Contact Map0.597
3mogA30.56721000.65Contact Map0.735
1f0yA20.4091000.738Contact Map0.674
1zejA10.40061000.749Contact Map0.683
4e12A10.38941000.768Contact Map0.615
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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