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OPENSEQ.org
FADB - Fatty acid oxidation complex subunit alpha
UniProt: P21177 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10279
Length: 729 (708)
Sequences: 1188
Seq/Len: 1.68
FADB
Paralog alert: 0.71 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FADB FADJ PAAH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
346_D 350_T 4.589 1.00
688_Q 704_R 4.131 1.00
114_L 136_G 3.48 1.00
167_I 254_A 3.152 1.00
333_A 381_I 3.139 1.00
47_E 97_R 2.976 1.00
152_V 269_A 2.888 1.00
442_R 445_N 2.748 1.00
491_V 498_F 2.715 1.00
364_L 369_I 2.711 1.00
461_V 481_A 2.561 1.00
107_A 124_T 2.519 1.00
292_I 659_V 2.468 1.00
629_A 686_M 2.442 1.00
129_A 184_V 2.419 1.00
316_A 395_I 2.417 1.00
315_Q 392_R 2.411 1.00
265_G 268_E 2.409 1.00
371_G 375_A 2.402 1.00
145_M 254_A 2.282 1.00
684_L 707_A 2.265 0.99
434_S 467_E 2.254 0.99
396_V 418_V 2.199 0.99
164_L 258_I 2.188 0.99
317_A 393_V 2.153 0.99
44_G 97_R 2.149 0.99
253_T 279_P 2.126 0.99
364_L 374_L 2.112 0.99
321_A 352_G 2.108 0.99
481_A 488_P 2.076 0.99
409_A 413_E 2.075 0.99
547_D 584_K 2.072 0.99
400_V 410_V 2.068 0.99
118_C 135_I 2.065 0.99
286_A 290_V 2.035 0.99
404_P 435_E 2.033 0.99
550_H 576_F 2.025 0.99
470_S 473_T 1.992 0.98
257_T 276_S 1.991 0.98
639_V 672_F 1.986 0.98
23_D 60_N 1.984 0.98
317_A 390_F 1.976 0.98
95_F 123_A 1.956 0.98
332_S 480_W 1.954 0.98
55_L 103_V 1.95 0.98
65_I 120_C 1.946 0.98
360_L 377_V 1.936 0.98
644_E 702_G 1.914 0.98
444_E 468_K 1.911 0.98
411_L 424_L 1.908 0.98
522_K 624_E 1.907 0.98
636_V 674_W 1.882 0.97
701_E 705_N 1.85 0.97
418_V 422_T 1.846 0.97
330_Y 359_L 1.826 0.97
360_L 374_L 1.776 0.96
390_F 393_V 1.775 0.96
527_M 631_M 1.757 0.96
158_L 162_S 1.751 0.96
158_L 183_L 1.747 0.96
167_I 258_I 1.745 0.96
415_E 440_L 1.734 0.95
658_L 671_A 1.722 0.95
338_P 380_T 1.718 0.95
316_A 332_S 1.717 0.95
514_L 523_I 1.709 0.95
162_S 165_E 1.707 0.95
474_I 490_V 1.697 0.95
435_E 438_N 1.693 0.94
15_D 202_R 1.662 0.94
654_A 672_F 1.66 0.94
498_F 657_A 1.66 0.94
13_L 198_K 1.654 0.94
705_N 709_H 1.651 0.93
158_L 181_I 1.648 0.93
135_I 183_L 1.647 0.93
18_A 55_L 1.629 0.93
686_M 689_Q 1.622 0.93
63_A 112_Y 1.611 0.92
361_N 374_L 1.608 0.92
509_G 516_D 1.604 0.92
129_A 135_I 1.604 0.92
54_G 201_L 1.595 0.92
351_L 355_E 1.578 0.91
459_P 487_T 1.578 0.91
137_L 154_M 1.576 0.91
46_L 55_L 1.571 0.91
311_E 472_E 1.57 0.91
702_G 713_Y 1.567 0.91
421_D 445_N 1.559 0.91
363_Q 366_R 1.557 0.91
512_Q 515_R 1.557 0.91
449_M 481_A 1.555 0.91
105_T 125_D 1.546 0.90
109_V 113_A 1.528 0.89
426_S 433_I 1.526 0.89
334_W 377_V 1.524 0.89
534_P 540_L 1.523 0.89
118_C 183_L 1.518 0.89
406_V 410_V 1.511 0.89
22_F 35_T 1.509 0.89
387_Y 417_K 1.504 0.88
56_L 201_L 1.501 0.88
96_N 100_D 1.497 0.88
376_G 380_T 1.494 0.88
404_P 436_L 1.49 0.88
516_D 630_R 1.49 0.88
154_M 183_L 1.487 0.88
526_V 628_I 1.486 0.88
158_L 166_I 1.485 0.88
59_S 63_A 1.482 0.87
643_L 654_A 1.481 0.87
684_L 704_R 1.481 0.87
648_I 654_A 1.463 0.87
17_I 56_L 1.462 0.87
623_S 626_E 1.462 0.87
264_F 272_L 1.457 0.86
266_R 270_L 1.454 0.86
503_L 540_L 1.451 0.86
637_N 700_P 1.447 0.86
382_H 389_G 1.442 0.85
349_L 352_G 1.44 0.85
395_I 480_W 1.435 0.85
526_V 624_E 1.435 0.85
123_A 153_R 1.427 0.85
374_L 378_I 1.426 0.85
56_L 198_K 1.419 0.84
21_V 58_R 1.401 0.83
509_G 630_R 1.401 0.83
349_L 385_L 1.398 0.83
408_K 439_A 1.397 0.83
436_L 446_F 1.391 0.83
259_E 263_R 1.391 0.83
676_D 713_Y 1.381 0.82
166_I 183_L 1.379 0.82
640_V 675_L 1.377 0.82
463_I 478_V 1.374 0.82
188_V 196_G 1.372 0.81
625_E 629_A 1.37 0.81
651_P 676_D 1.37 0.81
151_S 269_A 1.369 0.81
342_K 413_E 1.361 0.81
17_I 202_R 1.361 0.81
118_C 121_V 1.355 0.80
357_A 361_N 1.352 0.80
324_M 497_F 1.351 0.80
632_M 668_H 1.35 0.80
145_M 280_L 1.346 0.80
400_V 406_V 1.345 0.80
317_A 340_V 1.34 0.79
145_M 257_T 1.339 0.79
360_L 456_H 1.336 0.79
40_G 97_R 1.336 0.79
406_V 409_A 1.335 0.79
22_F 65_I 1.334 0.79
641_R 644_E 1.332 0.79
449_M 477_V 1.325 0.78
498_F 648_I 1.324 0.78
177_Q 181_I 1.324 0.78
412_A 439_A 1.324 0.78
384_T 389_G 1.32 0.78
518_A 522_K 1.318 0.78
155_P 158_L 1.313 0.77
363_Q 368_K 1.311 0.77
43_I 98_L 1.31 0.77
317_A 384_T 1.307 0.77
447_C 477_V 1.306 0.77
253_T 280_L 1.306 0.77
237_K 256_K 1.305 0.77
140_T 254_A 1.3 0.76
35_T 39_L 1.296 0.76
375_A 379_S 1.296 0.76
449_M 480_W 1.287 0.75
240_V 244_A 1.278 0.75
591_R 605_D 1.278 0.75
285_E 288_A 1.276 0.74
164_L 236_A 1.274 0.74
489_I 657_A 1.274 0.74
253_T 256_K 1.273 0.74
498_F 671_A 1.271 0.74
612_L 619_K 1.271 0.74
553_Q 573_D 1.266 0.74
466_G 469_S 1.265 0.73
52_L 55_L 1.26 0.73
249_P 285_E 1.258 0.73
636_V 675_L 1.256 0.73
423_V 476_K 1.256 0.73
186_G 203_Q 1.252 0.72
434_S 493_D 1.251 0.72
21_V 60_N 1.25 0.72
503_L 635_M 1.249 0.72
580_R 605_D 1.247 0.72
675_L 683_Y 1.244 0.72
52_L 103_V 1.243 0.72
629_A 633_I 1.237 0.71
46_L 52_L 1.237 0.71
166_I 181_I 1.236 0.71
248_Y 667_F 1.233 0.71
18_A 368_K 1.229 0.70
49_Q 52_L 1.227 0.70
500_N 648_I 1.227 0.70
487_T 660_Y 1.226 0.70
676_D 707_A 1.226 0.70
321_A 343_D 1.225 0.70
499_V 648_I 1.221 0.70
550_H 577_D 1.221 0.70
498_F 658_L 1.22 0.70
108_A 197_A 1.219 0.69
423_V 467_E 1.217 0.69
415_E 441_E 1.217 0.69
633_I 683_Y 1.217 0.69
416_Q 441_E 1.216 0.69
514_L 571_A 1.214 0.69
644_E 701_E 1.213 0.69
688_Q 691_Q 1.211 0.69
494_C 500_N 1.208 0.68
502_V 635_M 1.205 0.68
341_M 352_G 1.204 0.68
171_K 177_Q 1.202 0.68
550_H 581_F 1.197 0.67
550_H 573_D 1.196 0.67
494_C 647_I 1.194 0.67
235_I 238_G 1.193 0.67
581_F 584_K 1.191 0.67
419_R 422_T 1.183 0.66
411_L 440_L 1.181 0.66
311_E 445_N 1.181 0.66
37_A 41_E 1.18 0.66
357_A 378_I 1.176 0.65
321_A 341_M 1.175 0.65
405_K 408_K 1.174 0.65
303_A 649_A 1.174 0.65
513_L 518_A 1.172 0.65
47_E 101_L 1.171 0.65
491_V 657_A 1.171 0.65
346_D 385_L 1.17 0.65
341_M 410_V 1.168 0.65
155_P 269_A 1.163 0.64
702_G 706_K 1.161 0.64
43_I 97_R 1.157 0.64
681_A 685_D 1.153 0.63
272_L 276_S 1.152 0.63
541_L 549_A 1.152 0.63
704_R 707_A 1.151 0.63
682_K 685_D 1.149 0.63
704_R 708_R 1.147 0.63
499_V 662_L 1.145 0.62
20_L 55_L 1.145 0.62
321_A 418_V 1.144 0.62
581_F 585_N 1.142 0.62
337_V 480_W 1.14 0.62
428_T 497_F 1.138 0.62
703_L 707_A 1.138 0.62
127_R 157_M 1.137 0.62
131_P 189_K 1.135 0.61
449_M 461_V 1.134 0.61
531_F 674_W 1.133 0.61
531_F 636_V 1.127 0.61
502_V 639_V 1.123 0.60
165_E 169_A 1.12 0.60
452_F 458_M 1.12 0.60
152_V 155_P 1.119 0.60
506_Y 664_F 1.116 0.59
240_V 255_V 1.114 0.59
640_V 706_K 1.112 0.59
370_D 373_K 1.112 0.59
264_F 268_E 1.108 0.59
648_I 672_F 1.105 0.58
141_K 172_D 1.104 0.58
388_A 391_D 1.101 0.58
214_K 219_L 1.1 0.58
324_M 427_N 1.099 0.58
128_L 186_G 1.099 0.58
141_K 666_P 1.098 0.58
280_L 283_T 1.098 0.58
427_N 497_F 1.098 0.58
237_K 259_E 1.098 0.58
311_E 470_S 1.096 0.57
342_K 387_Y 1.095 0.57
447_C 474_I 1.095 0.57
576_F 581_F 1.094 0.57
99_E 219_L 1.091 0.57
451_F 484_M 1.091 0.57
333_A 356_A 1.09 0.57
363_Q 369_I 1.09 0.57
478_V 490_V 1.088 0.57
113_A 182_G 1.083 0.56
639_V 654_A 1.08 0.56
545_G 584_K 1.08 0.56
535_M 543_V 1.076 0.55
408_K 435_E 1.075 0.55
605_D 608_V 1.073 0.55
31_L 120_C 1.073 0.55
16_G 53_K 1.072 0.55
500_N 505_P 1.071 0.55
687_A 697_Y 1.07 0.55
154_M 158_L 1.07 0.55
73_F 281_A 1.068 0.54
315_Q 340_V 1.067 0.54
529_K 624_E 1.065 0.54
313_P 647_I 1.061 0.54
633_I 686_M 1.061 0.54
683_Y 687_A 1.061 0.54
55_L 101_L 1.06 0.54
427_N 452_F 1.055 0.53
418_V 421_D 1.054 0.53
364_L 378_I 1.05 0.53
579_N 585_N 1.049 0.52
560_F 563_R 1.049 0.52
518_A 622_F 1.048 0.52
376_G 379_S 1.046 0.52
636_V 678_L 1.046 0.52
524_D 671_A 1.046 0.52
19_E 56_L 1.04 0.51
166_I 173_V 1.04 0.51
70_I 142_L 1.039 0.51
35_T 120_C 1.038 0.51
106_I 128_L 1.036 0.51
324_M 452_F 1.034 0.51
101_L 152_V 1.034 0.51
144_I 286_A 1.031 0.51
109_V 135_I 1.027 0.50
401_V 453_N 1.027 0.50
328_I 496_G 1.026 0.50
178_A 184_V 1.025 0.50
516_D 622_F 1.025 0.50
371_G 393_V 1.024 0.50
465_R 649_A 1.02 0.49
98_L 105_T 1.017 0.49
404_P 431_I 1.017 0.49
257_T 272_L 1.017 0.49
528_E 539_Y 1.017 0.49
168_A 184_V 1.015 0.49
106_I 201_L 1.014 0.49
126_Y 200_V 1.014 0.49
324_M 428_T 1.011 0.48
330_Y 456_H 1.011 0.48
423_V 473_T 1.008 0.48
16_G 202_R 1.008 0.48
296_D 300_K 1.008 0.48
428_T 450_H 1.006 0.48
321_A 383_P 1.003 0.48
699_V 703_L 1.002 0.47
32_D 65_I 1.002 0.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1wdkA20.97941000.279Contact Map0.747
2wtbA10.97261000.298Contact Map0.679
4b3hA20.94791000.311Contact Map0.708
3zwcA20.96571000.335Contact Map0.744
1zcjA10.59951000.575Contact Map0.718
3k6jA10.60631000.591Contact Map0.587
3mogA30.55971000.655Contact Map0.723
1f0yA20.40191000.741Contact Map0.64
1zejA10.39511000.747Contact Map0.67
4e12A10.38131000.771Contact Map0.611
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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