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OPENSEQ.org
PAAH - 3-hydroxyadipyl-CoA dehydrogenase
UniProt: P76083 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13742
Length: 475 (455)
Sequences: 1698
Seq/Len: 3.73
PAAH
Paralog alert: 0.75 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FADB FADJ PAAH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
446_E 464_R 4.531 1.00
38_A 42_T 4.021 1.00
101_A 105_Q 3.218 1.00
25_A 73_L 2.978 1.00
134_N 137_R 2.816 1.00
118_T 125_I 2.748 1.00
7_T 84_A 2.709 1.00
9_A 82_L 2.65 1.00
63_A 67_E 2.65 1.00
92_A 102_L 2.558 1.00
30_Q 72_R 2.541 1.00
183_C 190_I 2.488 1.00
153_V 173_T 2.448 1.00
9_A 85_A 2.442 1.00
240_D 277_K 2.416 1.00
8_V 87_L 2.403 1.00
8_V 24_A 2.33 1.00
92_A 98_V 2.329 1.00
56_V 61_L 2.306 1.00
391_W 444_L 2.294 1.00
126_T 159_L 2.244 1.00
442_L 467_A 2.175 1.00
103_F 116_L 2.143 1.00
139_A 169_L 2.112 1.00
78_D 81_A 2.102 1.00
110_C 114_T 2.09 1.00
136_E 160_A 2.046 1.00
49_H 53_N 2.039 1.00
107_A 132_I 2.024 1.00
88_V 110_C 2.023 1.00
465_Q 469_L 2.013 1.00
52_L 69_T 1.976 1.00
461_S 465_Q 1.972 1.00
127_A 130_A 1.959 1.00
162_A 165_V 1.942 1.00
439_Q 443_R 1.931 1.00
56_V 66_C 1.912 1.00
96_L 127_A 1.911 1.00
96_L 128_I 1.891 1.00
401_A 430_L 1.874 1.00
405_L 415_I 1.872 1.00
166_V 182_R 1.872 1.00
243_F 269_V 1.869 1.00
208_E 392_R 1.826 0.99
52_L 66_C 1.819 0.99
107_A 133_K 1.813 0.99
136_E 162_A 1.803 0.99
141_L 173_T 1.783 0.99
406_Q 462_L 1.764 0.99
201_E 392_R 1.762 0.99
141_L 169_L 1.761 0.99
113_Q 137_R 1.761 0.99
128_I 138_V 1.757 0.99
24_A 172_L 1.736 0.99
206_L 216_I 1.728 0.99
82_L 85_A 1.726 0.99
181_V 418_A 1.715 0.99
53_N 66_C 1.708 0.99
220_L 393_T 1.693 0.99
26_S 69_T 1.688 0.99
201_E 208_E 1.677 0.99
274_L 278_S 1.67 0.99
170_C 182_R 1.662 0.99
173_T 180_P 1.651 0.99
111_P 114_T 1.648 0.99
93_S 98_V 1.627 0.99
108_E 133_K 1.616 0.98
221_R 232_E 1.613 0.98
110_C 116_L 1.606 0.98
442_L 446_E 1.605 0.98
68_R 72_R 1.583 0.98
100_K 131_E 1.566 0.98
87_L 172_L 1.561 0.98
273_R 280_L 1.56 0.98
53_N 57_T 1.56 0.98
419_M 429_P 1.559 0.98
13_S 44_A 1.557 0.98
98_V 102_L 1.555 0.98
22_E 51_R 1.549 0.98
462_L 466_R 1.539 0.98
97_E 100_K 1.53 0.98
74_I 81_A 1.512 0.97
190_I 418_A 1.51 0.97
443_R 446_E 1.502 0.97
411_S 414_D 1.499 0.97
442_L 464_R 1.494 0.97
66_C 70_L 1.481 0.97
103_F 128_I 1.473 0.97
96_L 123_I 1.472 0.97
234_T 242_N 1.472 0.97
243_F 266_Q 1.469 0.97
67_E 71_K 1.459 0.97
266_Q 270_I 1.454 0.96
190_I 429_P 1.454 0.96
212_A 215_V 1.448 0.96
191_V 423_V 1.443 0.96
462_L 473_Y 1.442 0.96
38_A 77_T 1.428 0.96
21_A 33_L 1.423 0.96
219_A 390_I 1.421 0.96
280_L 284_D 1.418 0.96
7_T 32_L 1.41 0.96
82_L 109_V 1.404 0.95
267_E 271_G 1.402 0.95
68_R 71_K 1.395 0.95
98_V 101_A 1.39 0.95
444_L 447_N 1.388 0.95
100_K 127_A 1.387 0.95
446_E 449_Q 1.385 0.95
7_T 30_Q 1.381 0.95
395_A 444_L 1.379 0.95
215_V 386_P 1.37 0.95
155_V 170_C 1.365 0.94
80_H 83_A 1.346 0.94
104_A 131_E 1.335 0.94
135_P 160_A 1.334 0.93
122_S 245_V 1.333 0.93
13_S 35_D 1.332 0.93
272_G 278_S 1.33 0.93
151_K 179_Q 1.327 0.93
442_L 463_L 1.322 0.93
420_R 431_A 1.311 0.93
49_H 70_L 1.31 0.93
117_T 139_A 1.303 0.92
55_R 58_R 1.302 0.92
398_I 432_W 1.292 0.92
191_V 418_A 1.288 0.92
63_A 66_C 1.284 0.92
100_K 104_A 1.271 0.91
79_I 109_V 1.271 0.91
430_L 433_G 1.266 0.91
446_E 459_P 1.261 0.91
45_I 73_L 1.261 0.91
399_N 460_C 1.254 0.90
433_G 441_I 1.25 0.90
96_L 100_K 1.244 0.90
434_A 473_Y 1.242 0.90
11_I 106_L 1.233 0.89
140_G 156_V 1.232 0.89
86_D 111_P 1.229 0.89
43_R 47_G 1.228 0.89
441_I 445_L 1.228 0.89
345_D 349_G 1.224 0.89
190_I 419_M 1.218 0.89
402_L 433_G 1.216 0.89
9_A 32_L 1.215 0.88
403_D 406_Q 1.208 0.88
406_Q 460_C 1.207 0.88
220_L 230_P 1.207 0.88
45_I 49_H 1.206 0.88
64_E 68_R 1.203 0.88
41_L 77_T 1.199 0.88
410_A 415_I 1.198 0.88
440_R 443_R 1.196 0.87
105_Q 108_E 1.194 0.87
179_Q 421_L 1.191 0.87
440_R 444_L 1.185 0.87
398_I 433_G 1.181 0.86
243_F 270_I 1.18 0.86
157_S 163_A 1.164 0.85
62_T 65_T 1.164 0.85
274_L 277_K 1.163 0.85
201_E 456_R 1.163 0.85
464_R 468_L 1.159 0.85
247_C 251_N 1.158 0.85
269_V 274_L 1.158 0.85
7_T 85_A 1.155 0.85
439_Q 467_A 1.153 0.85
153_V 180_P 1.151 0.85
39_E 42_T 1.148 0.84
204_R 207_E 1.142 0.84
16_M 189_F 1.138 0.84
30_Q 74_I 1.133 0.83
126_T 185_S 1.132 0.83
195_A 233_L 1.122 0.82
55_R 60_K 1.117 0.82
13_S 33_L 1.116 0.82
48_I 51_R 1.108 0.81
227_P 233_L 1.107 0.81
34_Y 105_Q 1.103 0.81
139_A 165_V 1.1 0.81
412_E 434_A 1.1 0.81
87_L 141_L 1.1 0.81
466_R 471_S 1.099 0.81
106_L 110_C 1.092 0.80
76_V 81_A 1.091 0.80
194_V 401_A 1.091 0.80
141_L 172_L 1.09 0.80
42_T 46_D 1.087 0.80
45_I 75_P 1.082 0.79
391_W 395_A 1.082 0.79
129_A 138_V 1.082 0.79
195_A 397_I 1.071 0.78
116_L 132_I 1.07 0.78
268_L 273_R 1.069 0.78
345_D 348_A 1.066 0.78
438_W 470_E 1.06 0.77
243_F 274_L 1.054 0.77
34_Y 79_I 1.052 0.76
54_S 57_T 1.05 0.76
238_G 277_K 1.048 0.76
438_W 466_R 1.045 0.76
240_D 274_L 1.038 0.75
403_D 460_C 1.038 0.75
44_A 73_L 1.037 0.75
447_N 450_H 1.037 0.75
24_A 176_W 1.036 0.75
103_F 132_I 1.033 0.75
191_V 233_L 1.026 0.74
442_L 459_P 1.026 0.74
5_V 29_H 1.024 0.74
100_K 128_I 1.022 0.73
79_I 102_L 1.016 0.73
125_I 129_A 1.014 0.73
466_R 473_Y 1.014 0.73
434_A 470_E 1.014 0.73
139_A 166_V 1.013 0.73
198_Y 425_Y 1.013 0.73
122_S 187_P 1.013 0.73
465_Q 468_L 1.012 0.72
80_H 109_V 1.012 0.72
243_F 247_C 1.011 0.72
434_A 467_A 1.011 0.72
205_A 210_V 1.009 0.72
24_A 89_I 1.009 0.72
415_I 430_L 1.008 0.72
15_T 241_V 1.002 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1wdkA20.83581000.329Contact Map0.769
3mogA30.97471000.333Contact Map0.789
2wtbA10.85261000.334Contact Map0.684
4b3hA20.81261000.341Contact Map0.79
3zwcA20.84841000.344Contact Map0.776
3k6jA10.82951000.348Contact Map0.659
1zcjA10.84841000.358Contact Map0.77
1f0yA20.60211000.536Contact Map0.716
1zejA10.59581000.564Contact Map0.679
4e12A10.58951000.584Contact Map0.679
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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