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OPENSEQ.org
YDFI - Uncharacterized oxidoreductase YdfI
UniProt: P77260 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13821
Length: 486 (479)
Sequences: 1066
Seq/Len: 2.23
YDFI
Paralog alert: 0.63 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: MTLD UXAB UXUB YDFI YEIQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
42_D 89_R 3.512 1.00
41_A 270_W 2.794 1.00
57_V 108_V 2.751 1.00
317_D 477_K 2.725 1.00
259_I 275_A 2.613 1.00
325_Y 348_N 2.536 1.00
140_L 202_A 2.506 1.00
110_A 172_A 2.479 1.00
106_E 168_R 2.461 1.00
231_E 234_L 2.453 1.00
470_S 479_T 2.396 1.00
43_I 89_R 2.309 1.00
22_P 55_Y 2.216 1.00
308_Y 317_D 2.208 1.00
33_H 37_Q 2.174 1.00
235_A 239_Q 2.167 1.00
238_E 244_R 2.153 1.00
164_E 168_R 2.126 1.00
24_I 41_A 2.104 1.00
114_E 117_I 2.093 0.99
170_K 206_K 2.065 0.99
361_H 365_Q 2.063 0.99
113_C 168_R 2.057 0.99
96_K 111_A 2.031 0.99
118_A 267_R 2.025 0.99
25_V 117_I 2.002 0.99
190_H 219_S 1.964 0.99
326_G 330_Q 1.959 0.99
270_W 275_A 1.954 0.99
314_C 320_Y 1.92 0.99
399_V 460_F 1.888 0.99
301_Y 370_G 1.874 0.99
59_L 161_V 1.856 0.98
15_Y 42_D 1.815 0.98
55_Y 111_A 1.801 0.98
302_L 397_L 1.796 0.98
168_R 172_A 1.777 0.98
304_Y 416_I 1.768 0.98
478_A 481_A 1.767 0.98
16_D 19_N 1.757 0.98
157_T 160_G 1.756 0.98
112_M 165_A 1.743 0.97
179_V 192_M 1.739 0.97
209_Q 213_D 1.733 0.97
144_M 156_K 1.725 0.97
55_Y 96_K 1.724 0.97
291_M 333_A 1.694 0.97
269_E 272_K 1.667 0.96
7_S 10_A 1.662 0.96
471_L 479_T 1.646 0.96
329_L 347_A 1.645 0.96
205_V 209_Q 1.636 0.96
124_I 158_A 1.632 0.96
78_V 91_V 1.62 0.96
291_M 328_M 1.62 0.96
22_P 96_K 1.619 0.96
216_T 264_V 1.616 0.96
470_S 482_K 1.613 0.95
298_F 398_G 1.599 0.95
333_A 347_A 1.596 0.95
104_G 107_T 1.591 0.95
122_L 158_A 1.59 0.95
131_H 195_V 1.59 0.95
397_L 471_L 1.585 0.95
70_Q 74_N 1.584 0.95
25_V 57_V 1.572 0.95
20_L 53_G 1.556 0.94
291_M 347_A 1.55 0.94
382_V 460_F 1.549 0.94
382_V 399_V 1.534 0.94
216_T 262_N 1.533 0.94
75_L 90_V 1.527 0.93
385_H 390_S 1.525 0.93
193_R 197_T 1.517 0.93
42_D 46_T 1.514 0.93
302_L 401_G 1.509 0.93
127_K 372_Q 1.488 0.92
463_R 467_T 1.48 0.92
55_Y 117_I 1.458 0.91
196_V 217_F 1.458 0.91
167_A 171_A 1.454 0.91
177_F 215_V 1.44 0.90
56_E 94_V 1.436 0.90
106_E 110_A 1.425 0.90
303_G 314_C 1.417 0.89
120_V 177_F 1.411 0.89
206_K 209_Q 1.407 0.89
7_S 12_L 1.407 0.89
455_P 461_T 1.404 0.89
39_V 78_V 1.398 0.89
180_M 259_I 1.397 0.89
267_R 271_E 1.392 0.88
200_A 211_I 1.391 0.88
321_R 355_S 1.39 0.88
96_K 107_T 1.376 0.88
53_G 95_K 1.374 0.87
187_E 282_L 1.37 0.87
311_I 363_T 1.368 0.87
209_Q 212_E 1.362 0.87
283_P 336_L 1.358 0.87
299_L 320_Y 1.356 0.87
109_L 164_E 1.353 0.86
361_H 377_R 1.352 0.86
458_S 462_A 1.35 0.86
165_A 177_F 1.347 0.86
141_D 146_A 1.335 0.85
302_L 471_L 1.328 0.85
300_A 367_A 1.326 0.85
22_P 117_I 1.32 0.84
176_A 215_V 1.317 0.84
80_E 251_C 1.313 0.84
295_S 324_A 1.311 0.84
291_M 350_L 1.292 0.83
147_A 151_N 1.29 0.83
371_S 449_I 1.287 0.82
297_S 373_K 1.286 0.82
383_R 452_D 1.286 0.82
32_F 182_C 1.285 0.82
24_I 54_Y 1.28 0.82
319_H 481_A 1.28 0.82
109_L 168_R 1.279 0.82
286_E 337_K 1.278 0.82
211_I 217_F 1.274 0.82
162_I 196_V 1.263 0.81
278_V 283_P 1.26 0.81
447_K 456_D 1.256 0.80
201_Q 208_A 1.246 0.79
343_L 347_A 1.246 0.79
298_F 327_L 1.239 0.79
226_V 359_L 1.238 0.79
231_E 235_A 1.238 0.79
396_A 464_V 1.234 0.79
445_A 455_P 1.232 0.78
275_A 311_I 1.229 0.78
298_F 323_A 1.227 0.78
21_A 116_Q 1.217 0.77
311_I 366_I 1.204 0.76
107_T 110_A 1.203 0.76
23_R 118_A 1.198 0.76
167_A 203_V 1.195 0.75
40_Y 255_R 1.193 0.75
130_F 157_T 1.192 0.75
81_M 233_T 1.187 0.75
315_M 321_R 1.185 0.75
403_M 443_L 1.185 0.75
167_A 204_D 1.184 0.74
229_V 248_G 1.182 0.74
27_L 112_M 1.182 0.74
475_G 479_T 1.182 0.74
187_E 190_H 1.178 0.74
54_Y 93_V 1.177 0.74
404_R 468_Y 1.176 0.74
424_P 428_K 1.176 0.74
407_G 430_V 1.173 0.73
77_T 90_V 1.173 0.73
75_L 92_G 1.167 0.73
91_V 94_V 1.161 0.72
359_L 378_M 1.157 0.72
396_A 460_F 1.155 0.72
361_H 366_I 1.155 0.72
271_E 277_L 1.154 0.72
127_K 377_R 1.152 0.72
74_N 97_A 1.152 0.72
119_I 267_R 1.151 0.71
132_S 135_T 1.147 0.71
130_F 142_H 1.144 0.71
113_C 165_A 1.143 0.71
170_K 207_L 1.135 0.70
121_S 220_T 1.135 0.70
22_P 95_K 1.132 0.70
295_S 328_M 1.13 0.69
25_V 120_V 1.125 0.69
304_Y 364_W 1.123 0.69
163_V 196_V 1.121 0.69
319_H 477_K 1.12 0.68
425_V 448_A 1.118 0.68
325_Y 329_L 1.117 0.68
127_K 369_D 1.113 0.68
69_L 74_N 1.111 0.68
29_F 56_E 1.109 0.67
411_E 416_I 1.108 0.67
374_L 398_G 1.102 0.67
371_S 402_W 1.102 0.67
339_Q 408_G 1.1 0.66
71_Q 428_K 1.1 0.66
131_H 191_V 1.099 0.66
311_I 324_A 1.093 0.66
122_L 181_S 1.092 0.66
178_T 218_P 1.092 0.66
6_L 10_A 1.09 0.65
197_T 208_A 1.088 0.65
177_F 200_A 1.088 0.65
137_Q 198_S 1.081 0.64
144_M 157_T 1.078 0.64
49_F 272_K 1.077 0.64
163_V 200_A 1.068 0.63
381_S 395_L 1.068 0.63
72_Q 75_L 1.067 0.63
474_H 482_K 1.063 0.63
149_V 199_Y 1.06 0.62
163_V 199_Y 1.057 0.62
309_Q 313_D 1.057 0.62
120_V 162_I 1.053 0.61
312_N 316_E 1.052 0.61
291_M 332_Q 1.052 0.61
327_L 395_L 1.051 0.61
98_L 108_V 1.049 0.61
230_T 233_T 1.049 0.61
15_Y 92_G 1.049 0.61
160_G 199_Y 1.049 0.61
162_I 192_M 1.048 0.61
38_G 54_Y 1.047 0.61
332_Q 395_L 1.045 0.61
166_L 210_W 1.042 0.60
328_M 351_I 1.04 0.60
24_I 119_I 1.04 0.60
91_V 153_H 1.039 0.60
229_V 249_V 1.036 0.60
159_T 361_H 1.031 0.59
362_R 365_Q 1.031 0.59
441_Q 445_A 1.03 0.59
326_G 394_L 1.03 0.59
139_M 249_V 1.029 0.59
83_A 357_P 1.028 0.59
78_V 359_L 1.028 0.59
372_Q 377_R 1.026 0.59
306_A 320_Y 1.024 0.58
476_A 480_V 1.022 0.58
29_F 94_V 1.021 0.58
290_R 384_W 1.018 0.58
304_Y 405_Y 1.015 0.57
96_K 110_A 1.014 0.57
81_M 224_R 1.014 0.57
308_Y 405_Y 1.012 0.57
420_D 450_F 1.01 0.57
364_W 405_Y 1.01 0.57
163_V 211_I 1.01 0.57
105_L 161_V 1.009 0.57
33_H 36_H 1.009 0.57
365_Q 377_R 1.003 0.56
175_P 265_A 1 0.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4im7A10.99791000.126Contact Map0.714
1lj8A10.99181000.134Contact Map0.769
3h2zA10.77161000.406Contact Map0.588
3cuxA10.440313.80.984Contact Map0.132
3bkhA10.4918110.985Contact Map0.203
1z9bA10.172810.70.985Contact Map0.004
2llwA10.139910.50.985Contact Map0.389
1rijA10.04739.40.985Contact Map0
3cuzA10.44248.20.985Contact Map0.157
2lzfA20.13175.80.986Contact Map0.104
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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