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OPENSEQ.org
MTLD - Mannitol-1-phosphate 5-dehydrogenase
UniProt: P09424 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10616
Length: 382 (380)
Sequences: 1350
Seq/Len: 3.55
MTLD
Paralog alert: 0.54 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: MTLD UXAB UXUB YDFI YEIQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
30_A 73_V 3.171 1.00
249_K 275_Q 2.971 1.00
128_T 154_D 2.934 1.00
232_H 241_D 2.779 1.00
184_V 199_M 2.561 1.00
16_I 196_I 2.536 1.00
288_D 292_R 2.526 1.00
245_R 282_E 2.387 1.00
78_A 105_K 2.376 1.00
65_A 76_L 2.28 1.00
222_I 327_G 2.242 1.00
250_G 253_E 2.139 1.00
105_K 109_Q 2.13 1.00
101_K 105_K 2.122 1.00
238_A 244_I 2.077 1.00
75_D 109_Q 2.064 1.00
17_G 58_D 2.009 1.00
131_K 135_M 2.003 1.00
45_S 59_T 1.972 1.00
196_I 199_M 1.929 1.00
77_I 102_G 1.907 1.00
144_A 148_E 1.905 1.00
18_K 58_D 1.894 1.00
28_T 65_A 1.843 0.99
140_E 144_A 1.84 0.99
3_A 26_Q 1.819 0.99
3_A 25_I 1.795 0.99
28_T 76_L 1.757 0.99
256_G 274_I 1.754 0.99
72_D 75_D 1.734 0.99
115_L 150_V 1.727 0.99
245_R 249_K 1.715 0.99
94_R 97_P 1.713 0.99
225_Y 297_P 1.701 0.99
311_L 328_I 1.7 0.99
107_K 141_D 1.684 0.99
29_F 63_V 1.683 0.99
4_L 30_A 1.667 0.99
48_V 60_V 1.647 0.99
250_G 323_N 1.616 0.98
134_V 152_F 1.613 0.98
314_T 319_L 1.596 0.98
202_T 207_A 1.576 0.98
226_L 326_E 1.571 0.98
226_L 330_A 1.571 0.98
215_T 256_G 1.554 0.98
141_D 144_A 1.544 0.98
74_V 105_K 1.538 0.97
151_G 190_K 1.529 0.97
224_A 294_G 1.515 0.97
32_V 98_A 1.513 0.97
233_Q 237_D 1.513 0.97
236_R 240_L 1.502 0.97
278_L 282_E 1.5 0.97
144_A 147_E 1.499 0.97
49_H 57_V 1.492 0.97
368_S 372_S 1.484 0.97
146_V 152_F 1.474 0.96
83_V 115_L 1.454 0.96
346_A 350_A 1.451 0.96
104_V 139_P 1.434 0.96
104_V 108_E 1.412 0.95
151_G 188_Q 1.411 0.95
125_R 128_T 1.405 0.95
117_I 130_L 1.4 0.95
239_I 245_R 1.393 0.95
135_M 143_K 1.37 0.94
107_K 139_P 1.368 0.94
85_T 95_I 1.352 0.93
256_G 270_H 1.345 0.93
65_A 72_D 1.329 0.93
97_P 137_A 1.329 0.93
102_G 115_L 1.328 0.93
219_G 248_V 1.323 0.93
82_L 115_L 1.319 0.92
235_I 293_V 1.31 0.92
222_I 251_A 1.309 0.92
362_S 366_A 1.305 0.92
125_R 206_M 1.299 0.92
104_V 142_A 1.279 0.91
133_H 136_N 1.266 0.90
255_S 324_L 1.264 0.90
348_L 360_Q 1.25 0.89
177_E 283_N 1.25 0.89
47_Q 59_T 1.249 0.89
16_I 27_L 1.246 0.89
227_G 238_A 1.243 0.89
8_A 29_F 1.242 0.89
101_K 104_V 1.238 0.89
74_V 101_K 1.237 0.89
348_L 357_A 1.236 0.89
223_T 244_I 1.223 0.88
251_A 324_L 1.22 0.88
99_I 134_V 1.219 0.88
215_T 274_I 1.214 0.88
215_T 252_M 1.21 0.87
232_H 334_F 1.21 0.87
347_A 351_D 1.206 0.87
344_E 347_A 1.201 0.87
230_A 243_K 1.199 0.87
310_P 324_L 1.199 0.87
118_I 184_V 1.193 0.86
18_K 180_S 1.186 0.86
75_D 78_A 1.182 0.86
228_K 291_E 1.18 0.85
103_Q 145_W 1.175 0.85
4_L 102_G 1.171 0.85
6_F 77_I 1.169 0.85
288_D 293_V 1.167 0.85
43_R 170_D 1.165 0.84
214_F 313_G 1.164 0.84
118_I 155_S 1.161 0.84
45_S 61_S 1.16 0.84
87_V 95_I 1.153 0.84
266_D 269_K 1.152 0.84
100_A 137_A 1.151 0.83
4_L 77_I 1.151 0.83
341_Q 344_E 1.15 0.83
114_P 150_V 1.144 0.83
189_F 194_P 1.143 0.83
230_A 241_D 1.14 0.83
271_A 275_Q 1.138 0.83
87_V 194_P 1.137 0.82
3_A 20_L 1.137 0.82
301_L 327_G 1.135 0.82
210_E 260_I 1.133 0.82
215_T 277_I 1.131 0.82
123_M 126_G 1.128 0.82
100_A 134_V 1.12 0.81
343_Q 347_A 1.118 0.81
373_E 377_A 1.113 0.81
27_L 30_A 1.111 0.80
50_V 176_V 1.106 0.80
8_A 63_V 1.103 0.80
230_A 244_I 1.103 0.80
48_V 286_L 1.101 0.80
77_I 115_L 1.1 0.79
228_K 334_F 1.099 0.79
233_Q 289_D 1.094 0.79
47_Q 168_T 1.09 0.79
288_D 306_R 1.088 0.78
104_V 138_L 1.085 0.78
2_K 26_Q 1.084 0.78
336_S 349_I 1.082 0.78
289_D 292_R 1.079 0.78
107_K 142_A 1.077 0.77
252_M 278_L 1.076 0.77
308_I 328_I 1.073 0.77
222_I 247_V 1.072 0.77
6_F 95_I 1.066 0.76
239_I 278_L 1.066 0.76
11_I 120_C 1.065 0.76
376_T 379_K 1.064 0.76
299_R 305_D 1.063 0.76
286_L 307_L 1.063 0.76
299_R 306_R 1.061 0.76
356_A 360_Q 1.061 0.76
135_M 146_V 1.059 0.76
235_I 290_V 1.056 0.75
4_L 80_V 1.055 0.75
9_G 13_R 1.053 0.75
78_A 102_G 1.053 0.75
234_T 237_D 1.048 0.75
100_A 146_V 1.047 0.75
349_I 353_G 1.037 0.74
158_D 280_R 1.034 0.73
348_L 361_I 1.033 0.73
353_G 366_A 1.031 0.73
221_A 300_K 1.028 0.73
128_T 188_Q 1.023 0.72
161_V 286_L 1.018 0.72
215_T 255_S 1.018 0.72
83_V 117_I 1.015 0.71
47_Q 57_V 1.014 0.71
298_L 331_A 1.011 0.71
11_I 15_F 1.009 0.71
117_I 150_V 1.008 0.71
36_V 39_A 1.007 0.70
242_E 246_A 1.001 0.70
344_E 348_L 1 0.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3h2zA111000.025Contact Map0.7
1lj8A10.98171000.101Contact Map0.703
4im7A10.97911000.102Contact Map0.712
2ew2A20.780198.60.904Contact Map0.543
3hn2A40.785398.40.908Contact Map0.584
3i83A20.803798.20.914Contact Map0.579
2qytA10.7618980.919Contact Map0.436
3egoA20.764497.50.927Contact Map0.444
3hwrA20.76797.40.927Contact Map0.526
3ghyA20.793297.30.929Contact Map0.564
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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