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OPENSEQ.org
YEIQ - Uncharacterized oxidoreductase YeiQ
UniProt: P33029 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12036
Length: 488 (484)
Sequences: 1123
Seq/Len: 2.32
YEIQ
Paralog alert: 0.63 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: MTLD UXAB UXUB YDFI YEIQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
45_D 92_I 3.484 1.00
60_I 111_I 3.226 1.00
44_T 273_W 2.815 1.00
320_D 479_H 2.717 1.00
328_R 351_D 2.645 1.00
109_A 171_R 2.563 1.00
234_D 237_L 2.472 1.00
472_Q 481_A 2.457 1.00
46_R 92_I 2.452 1.00
262_V 278_V 2.423 1.00
143_T 205_K 2.378 1.00
113_E 175_R 2.363 1.00
238_V 242_Q 2.264 1.00
311_F 320_D 2.235 1.00
27_I 44_T 2.196 1.00
241_S 247_N 2.144 1.00
25_S 58_C 2.141 1.00
364_H 368_Q 2.135 1.00
116_C 171_R 2.125 1.00
193_H 222_G 2.125 1.00
36_H 40_Q 2.113 1.00
28_V 120_V 2.086 1.00
121_A 270_R 2.068 0.99
117_E 120_V 2.063 0.99
167_E 171_R 2.048 0.99
173_R 209_E 2.03 0.99
273_W 278_V 2.019 0.99
107_S 110_A 1.977 0.99
317_C 323_F 1.965 0.99
99_E 114_K 1.892 0.99
18_Y 45_D 1.888 0.99
304_Y 373_G 1.87 0.99
10_P 13_V 1.834 0.98
58_C 114_K 1.823 0.98
305_L 400_L 1.821 0.98
115_F 168_A 1.812 0.98
329_T 333_D 1.81 0.98
62_L 164_I 1.779 0.98
402_V 462_F 1.777 0.98
307_Y 419_I 1.76 0.98
212_G 216_E 1.758 0.98
171_R 175_R 1.757 0.98
480_Q 483_L 1.755 0.98
58_C 99_E 1.736 0.98
160_S 163_G 1.729 0.97
472_Q 484_N 1.68 0.97
196_K 200_L 1.664 0.97
147_R 159_H 1.648 0.96
182_V 195_V 1.641 0.96
219_S 267_V 1.64 0.96
294_M 336_A 1.638 0.96
208_P 212_G 1.633 0.96
301_F 401_G 1.618 0.96
294_M 331_M 1.609 0.96
25_S 99_E 1.605 0.96
19_D 22_Q 1.593 0.95
400_L 473_I 1.586 0.95
336_A 350_A 1.577 0.95
388_H 393_T 1.573 0.95
73_R 77_H 1.572 0.95
305_L 404_G 1.57 0.95
332_L 350_A 1.561 0.95
125_L 161_A 1.555 0.95
81_V 94_V 1.551 0.94
130_K 375_Q 1.549 0.94
134_I 198_A 1.545 0.94
56_G 98_H 1.541 0.94
294_M 350_A 1.537 0.94
324_R 358_A 1.532 0.94
473_I 481_A 1.515 0.94
45_D 49_N 1.515 0.94
385_I 402_V 1.502 0.93
209_E 212_G 1.496 0.93
199_V 220_F 1.493 0.93
23_L 56_G 1.492 0.93
42_L 81_V 1.492 0.93
109_A 113_E 1.49 0.93
272_A 275_V 1.482 0.93
465_A 469_A 1.479 0.92
219_S 265_N 1.467 0.92
281_V 286_P 1.45 0.91
58_C 120_V 1.449 0.91
82_L 91_V 1.443 0.91
127_I 161_A 1.436 0.91
214_I 220_F 1.435 0.91
10_P 15_A 1.424 0.90
460_P 464_Q 1.421 0.90
203_A 214_I 1.415 0.90
28_V 60_I 1.4 0.89
180_F 218_V 1.399 0.89
477_G 481_A 1.388 0.89
305_L 473_I 1.374 0.88
78_L 93_I 1.374 0.88
59_E 97_V 1.37 0.88
99_E 110_A 1.364 0.88
302_L 323_F 1.359 0.87
123_V 180_F 1.355 0.87
306_G 317_C 1.347 0.87
385_I 462_F 1.345 0.87
449_R 458_D 1.335 0.86
212_G 215_K 1.33 0.86
190_D 285_L 1.329 0.86
110_A 113_E 1.321 0.85
170_K 174_E 1.32 0.85
168_A 180_F 1.316 0.85
374_S 451_V 1.316 0.85
457_P 463_V 1.315 0.85
204_E 211_A 1.313 0.85
112_I 171_R 1.309 0.85
83_E 254_C 1.309 0.85
173_R 207_S 1.302 0.84
314_I 366_T 1.3 0.84
303_A 370_A 1.298 0.84
234_D 238_V 1.297 0.84
364_H 380_R 1.296 0.84
112_I 167_E 1.286 0.83
270_R 274_E 1.284 0.83
27_I 57_I 1.28 0.83
28_V 123_V 1.271 0.82
183_L 262_V 1.265 0.82
170_K 207_S 1.263 0.82
386_R 455_D 1.259 0.81
447_S 457_P 1.258 0.81
314_I 369_I 1.255 0.81
300_S 376_K 1.252 0.81
35_F 185_C 1.251 0.81
399_A 466_I 1.234 0.80
133_C 160_S 1.233 0.80
298_S 327_A 1.231 0.79
24_Q 119_Q 1.229 0.79
154_T 157_E 1.216 0.78
25_S 120_V 1.212 0.78
286_P 339_L 1.211 0.78
84_K 236_S 1.208 0.78
301_F 330_L 1.204 0.77
298_S 331_M 1.204 0.77
293_R 387_I 1.203 0.77
140_A 201_G 1.203 0.77
57_I 96_A 1.202 0.77
346_L 350_A 1.2 0.77
364_H 369_I 1.199 0.77
80_T 93_I 1.199 0.77
322_A 483_L 1.197 0.77
179_P 218_V 1.195 0.76
170_K 206_R 1.192 0.76
294_M 353_L 1.19 0.76
200_L 211_A 1.189 0.76
165_L 199_V 1.188 0.76
124_S 223_T 1.185 0.76
130_K 380_R 1.184 0.76
190_D 193_H 1.184 0.76
144_S 149_I 1.183 0.75
278_V 314_I 1.183 0.75
362_L 381_M 1.181 0.75
301_F 326_A 1.18 0.75
26_R 121_A 1.17 0.74
81_V 362_L 1.169 0.74
173_R 210_L 1.169 0.74
229_V 362_L 1.165 0.74
43_L 258_I 1.164 0.74
410_S 433_V 1.163 0.74
289_E 340_Q 1.16 0.73
25_S 98_H 1.159 0.73
232_A 251_A 1.159 0.73
30_F 115_F 1.154 0.73
72_L 77_H 1.148 0.72
406_M 445_L 1.148 0.72
166_V 199_V 1.142 0.72
150_H 154_T 1.138 0.71
135_D 138_T 1.137 0.71
428_K 450_E 1.136 0.71
318_M 324_R 1.13 0.71
133_C 145_N 1.129 0.71
399_A 462_F 1.122 0.70
94_V 97_V 1.115 0.69
108_L 164_I 1.114 0.69
449_R 455_D 1.111 0.69
32_F 59_E 1.108 0.68
322_A 479_H 1.106 0.68
311_F 408_Y 1.105 0.68
44_T 57_I 1.105 0.68
257_F 477_G 1.104 0.68
134_I 194_V 1.103 0.68
374_S 405_W 1.102 0.68
147_R 160_S 1.095 0.67
315_S 319_Q 1.094 0.67
189_P 297_G 1.088 0.66
130_K 372_D 1.085 0.66
476_F 480_Q 1.081 0.66
307_Y 367_W 1.081 0.66
180_F 203_A 1.078 0.65
125_L 184_S 1.077 0.65
166_V 203_A 1.076 0.65
330_L 398_L 1.074 0.65
169_L 213_W 1.073 0.65
233_T 236_S 1.073 0.65
162_P 364_H 1.071 0.65
384_G 398_L 1.071 0.65
4_I 13_V 1.066 0.64
328_R 332_L 1.066 0.64
163_G 202_M 1.064 0.64
316_D 319_Q 1.062 0.64
166_V 202_M 1.058 0.63
365_K 368_Q 1.057 0.63
331_M 354_I 1.057 0.63
312_A 316_D 1.056 0.63
294_M 335_Q 1.055 0.63
423_D 452_F 1.055 0.63
334_E 369_I 1.053 0.63
329_T 397_L 1.052 0.63
200_L 214_I 1.05 0.62
318_M 354_I 1.05 0.62
181_T 221_P 1.05 0.62
342_K 411_G 1.049 0.62
232_A 252_I 1.042 0.61
314_I 327_A 1.041 0.61
476_F 484_N 1.041 0.61
123_V 165_L 1.041 0.61
79_Y 227_R 1.04 0.61
35_F 40_Q 1.039 0.61
52_G 275_V 1.038 0.61
367_W 408_Y 1.038 0.61
354_I 358_A 1.038 0.61
407_R 470_W 1.035 0.61
274_E 280_M 1.031 0.60
77_H 100_C 1.031 0.60
122_I 270_R 1.03 0.60
375_Q 380_R 1.025 0.60
27_I 122_I 1.023 0.59
75_Q 248_D 1.022 0.59
372_D 424_P 1.022 0.59
307_Y 408_Y 1.021 0.59
257_F 283_D 1.02 0.59
147_R 150_H 1.016 0.59
32_F 97_V 1.016 0.59
78_L 95_G 1.014 0.58
140_A 197_N 1.009 0.58
427_D 431_E 1.008 0.58
30_F 161_A 1.007 0.58
335_Q 398_L 1.005 0.57
369_I 376_K 1.005 0.57
345_D 348_Q 1.003 0.57
478_A 481_A 1.001 0.57
165_L 195_V 1 0.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4im7A10.9981000.095Contact Map0.733
1lj8A10.99391000.102Contact Map0.772
3h2zA10.76841000.385Contact Map0.617
3hn2A40.62723.10.981Contact Map0.524
1z9bA10.178318.80.982Contact Map0.037
2ew2A20.639313.20.983Contact Map0.352
2llwA10.139310.60.984Contact Map0.425
3i83A20.647510.30.984Contact Map0.453
2lzfA20.12919.20.985Contact Map0.171
3bkhA10.48988.90.985Contact Map0.268
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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