| UniProt: | P76422 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG14068 | ||
| Length: | 266 (262) | ||
| Sequences: | 2956 | ||
| Seq/Len: | 11.28 |
| THID
Paralog alert: 0.62 [within 20: 0.01] - ratio of genomes with paralogs Cluster includes: PDXK PDXY THID |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 24_L | 34_G | 3.421 | 1.00 | |
| 95_Q | 132_Q | 3.295 | 1.00 | |
| 88_E | 128_R | 3.273 | 1.00 | |
| 50_Q | 66_S | 3.031 | 1.00 | |
| 53_Y | 56_E | 2.982 | 1.00 | |
| 81_L | 90_V | 2.767 | 1.00 | |
| 174_L | 215_L | 2.708 | 1.00 | |
| 228_N | 231_D | 2.626 | 1.00 | |
| 78_I | 104_L | 2.591 | 1.00 | |
| 41_L | 59_F | 2.524 | 1.00 | |
| 30_L | 222_L | 2.388 | 1.00 | |
| 222_L | 227_T | 2.375 | 1.00 | |
| 149_A | 164_S | 2.326 | 1.00 | |
| 27_F | 221_A | 2.297 | 1.00 | |
| 32_A | 221_A | 2.249 | 1.00 | |
| 27_F | 34_G | 2.235 | 1.00 | |
| 12_T | 21_Q | 2.231 | 1.00 | |
| 143_A | 175_M | 2.202 | 1.00 | |
| 95_Q | 128_R | 2.179 | 1.00 | |
| 61_A | 92_E | 2.171 | 1.00 | |
| 8_T | 36_S | 2.154 | 1.00 | |
| 123_A | 127_S | 2.135 | 1.00 | |
| 6_A | 32_A | 2.125 | 1.00 | |
| 65_D | 93_R | 2.123 | 1.00 | |
| 41_L | 55_I | 2.054 | 1.00 | |
| 222_L | 225_R | 1.978 | 1.00 | |
| 27_F | 32_A | 1.959 | 1.00 | |
| 60_V | 86_I | 1.955 | 1.00 | |
| 64_L | 93_R | 1.879 | 1.00 | |
| 115_P | 119_P | 1.872 | 1.00 | |
| 110_A | 114_D | 1.839 | 1.00 | |
| 154_T | 157_E | 1.81 | 1.00 | |
| 136_I | 165_L | 1.798 | 1.00 | |
| 21_Q | 36_S | 1.767 | 1.00 | |
| 37_V | 64_L | 1.741 | 1.00 | |
| 117_L | 121_A | 1.727 | 1.00 | |
| 51_S | 62_A | 1.724 | 1.00 | |
| 201_P | 245_A | 1.686 | 1.00 | |
| 184_Q | 199_T | 1.679 | 1.00 | |
| 54_R | 82_A | 1.653 | 1.00 | |
| 196_Q | 230_A | 1.638 | 1.00 | |
| 237_K | 241_S | 1.622 | 1.00 | |
| 219_L | 233_V | 1.595 | 1.00 | |
| 94_L | 102_V | 1.59 | 1.00 | |
| 5_N | 74_D | 1.589 | 1.00 | |
| 78_I | 102_V | 1.585 | 1.00 | |
| 159_L | 195_E | 1.585 | 1.00 | |
| 6_A | 27_F | 1.579 | 1.00 | |
| 153_R | 157_E | 1.514 | 1.00 | |
| 54_R | 83_E | 1.513 | 1.00 | |
| 20_I | 38_I | 1.51 | 1.00 | |
| 147_L | 165_L | 1.498 | 1.00 | |
| 93_R | 96_R | 1.496 | 1.00 | |
| 92_E | 128_R | 1.495 | 1.00 | |
| 104_L | 133_V | 1.488 | 1.00 | |
| 185_S | 237_K | 1.463 | 1.00 | |
| 87_V | 125_L | 1.454 | 1.00 | |
| 57_P | 85_D | 1.453 | 1.00 | |
| 241_S | 245_A | 1.443 | 1.00 | |
| 65_D | 96_R | 1.442 | 1.00 | |
| 172_A | 229_W | 1.427 | 1.00 | |
| 144_A | 150_P | 1.409 | 1.00 | |
| 8_T | 27_F | 1.396 | 0.99 | |
| 222_L | 235_E | 1.386 | 0.99 | |
| 101_N | 134_S | 1.356 | 0.99 | |
| 65_D | 69_S | 1.355 | 0.99 | |
| 61_A | 89_A | 1.332 | 0.99 | |
| 144_A | 161_Q | 1.329 | 0.99 | |
| 135_L | 174_L | 1.325 | 0.99 | |
| 57_P | 89_A | 1.318 | 0.99 | |
| 84_T | 120_S | 1.318 | 0.99 | |
| 12_T | 42_V | 1.312 | 0.99 | |
| 160_E | 163_R | 1.294 | 0.99 | |
| 242_S | 245_A | 1.291 | 0.99 | |
| 166_L | 190_F | 1.286 | 0.99 | |
| 227_T | 231_D | 1.271 | 0.99 | |
| 37_V | 60_V | 1.259 | 0.99 | |
| 5_N | 71_V | 1.253 | 0.99 | |
| 189_L | 198_F | 1.237 | 0.98 | |
| 198_F | 234_Q | 1.235 | 0.98 | |
| 227_T | 235_E | 1.221 | 0.98 | |
| 81_L | 87_V | 1.22 | 0.98 | |
| 5_N | 35_C | 1.219 | 0.98 | |
| 134_S | 171_G | 1.217 | 0.98 | |
| 46_T | 70_D | 1.213 | 0.98 | |
| 130_L | 136_I | 1.201 | 0.98 | |
| 135_L | 229_W | 1.194 | 0.98 | |
| 162_G | 175_M | 1.193 | 0.98 | |
| 231_D | 234_Q | 1.192 | 0.98 | |
| 5_N | 72_R | 1.188 | 0.98 | |
| 151_H | 161_Q | 1.184 | 0.98 | |
| 26_T | 218_A | 1.171 | 0.98 | |
| 166_L | 192_R | 1.17 | 0.97 | |
| 26_T | 214_T | 1.164 | 0.97 | |
| 55_I | 59_F | 1.161 | 0.97 | |
| 28_S | 262_F | 1.16 | 0.97 | |
| 58_D | 62_A | 1.16 | 0.97 | |
| 61_A | 93_R | 1.157 | 0.97 | |
| 164_S | 167_A | 1.152 | 0.97 | |
| 144_A | 151_H | 1.147 | 0.97 | |
| 194_G | 230_A | 1.142 | 0.97 | |
| 30_L | 218_A | 1.129 | 0.97 | |
| 163_R | 167_A | 1.113 | 0.96 | |
| 230_A | 234_Q | 1.112 | 0.96 | |
| 214_T | 259_V | 1.112 | 0.96 | |
| 200_A | 237_K | 1.11 | 0.96 | |
| 166_L | 170_C | 1.087 | 0.96 | |
| 35_C | 73_I | 1.083 | 0.96 | |
| 158_M | 188_W | 1.083 | 0.96 | |
| 149_A | 160_E | 1.077 | 0.95 | |
| 198_F | 237_K | 1.071 | 0.95 | |
| 83_E | 86_I | 1.068 | 0.95 | |
| 187_D | 237_K | 1.067 | 0.95 | |
| 30_L | 225_R | 1.063 | 0.95 | |
| 147_L | 164_S | 1.061 | 0.95 | |
| 205_T | 257_G | 1.056 | 0.95 | |
| 223_R | 229_W | 1.056 | 0.95 | |
| 9_I | 90_V | 1.054 | 0.95 | |
| 190_F | 195_E | 1.043 | 0.94 | |
| 135_L | 172_A | 1.042 | 0.94 | |
| 15_S | 42_V | 1.042 | 0.94 | |
| 43_A | 59_F | 1.04 | 0.94 | |
| 159_L | 163_R | 1.036 | 0.94 | |
| 103_V | 223_R | 1.034 | 0.94 | |
| 162_G | 190_F | 1.022 | 0.93 | |
| 30_L | 221_A | 1.019 | 0.93 | |
| 160_E | 164_S | 1.017 | 0.93 | |
| 12_T | 38_I | 1.015 | 0.93 | |
| 43_A | 62_A | 1.015 | 0.93 | |
| 35_C | 71_V | 1.013 | 0.93 | |
| 84_T | 88_E | 1.01 | 0.93 | |
| 124_T | 128_R | 1.003 | 0.93 | |
| 109_L | 145_A | 1 | 0.92 | |
| 6_A | 224_P | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3rm5A | 2 | 0.985 | 100 | 0.305 | Contact Map | 0.764 |
| 2i5bA | 5 | 0.9887 | 100 | 0.308 | Contact Map | 0.808 |
| 1ub0A | 1 | 0.9699 | 100 | 0.36 | Contact Map | 0.785 |
| 1jxhA | 2 | 1 | 100 | 0.362 | Contact Map | 0.827 |
| 3h74A | 1 | 0.9774 | 100 | 0.377 | Contact Map | 0.663 |
| 2ddmA | 2 | 0.9774 | 100 | 0.395 | Contact Map | 0.715 |
| 3mbhA | 6 | 0.9812 | 100 | 0.4 | Contact Map | 0.772 |
| 2yxtA | 2 | 0.9812 | 100 | 0.405 | Contact Map | 0.706 |
| 3pzsA | 2 | 0.985 | 100 | 0.405 | Contact Map | 0.73 |
| 4jjpA | 2 | 0.985 | 100 | 0.413 | Contact Map | 0.9 |
Sequence Conservation (Image Generated using WebLogo v3)