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OPENSEQ.org
GHRA - Glyoxylate/hydroxypyruvate reductase A
UniProt: P75913 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13869
Length: 312 (299)
Sequences: 8567
Seq/Len: 28.65
GHRA
Paralog alert: 0.87 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: GHRA GHRB LDHD SERA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
209_N 212_L 4.797 1.00
232_V 235_D 4.133 1.00
210_Q 238_A 3.659 1.00
139_I 155_L 2.912 1.00
218_D 244_K 2.798 1.00
185_S 215_K 2.792 1.00
138_T 161_P 2.587 1.00
241_D 267_H 2.52 1.00
138_T 163_R 2.519 1.00
183_E 186_A 2.519 1.00
206_G 254_N 2.481 1.00
49_V 82_N 2.446 1.00
200_N 229_V 2.379 1.00
208_I 213_L 2.232 1.00
163_R 190_Q 2.203 1.00
140_G 187_F 2.198 1.00
140_G 191_C 2.192 1.00
40_D 58_K 2.175 1.00
49_V 53_A 2.154 1.00
111_F 193_V 2.149 1.00
222_L 231_V 2.131 1.00
104_V 155_L 2.124 1.00
188_L 212_L 2.087 1.00
220_A 245_V 2.033 1.00
113_R 116_D 2.025 1.00
189_S 215_K 2.022 1.00
214_E 244_K 2.003 1.00
139_I 160_F 1.974 1.00
186_A 190_Q 1.962 1.00
141_I 148_G 1.954 1.00
102_Y 277_A 1.952 1.00
118_R 122_N 1.949 1.00
144_A 164_C 1.925 1.00
238_A 242_S 1.916 1.00
192_R 217_P 1.908 1.00
236_L 248_A 1.907 1.00
237_L 267_H 1.907 1.00
104_V 158_W 1.898 1.00
267_H 270_V 1.87 1.00
221_Y 247_G 1.866 1.00
206_G 232_V 1.822 1.00
202_P 205_V 1.82 1.00
105_S 114_F 1.805 1.00
211_Q 215_K 1.804 1.00
150_K 153_Q 1.799 1.00
155_L 160_F 1.79 1.00
241_D 263_P 1.766 1.00
295_Q 300_E 1.765 1.00
188_L 208_I 1.75 1.00
107_V 193_V 1.725 1.00
213_L 239_A 1.719 1.00
53_A 83_P 1.713 1.00
110_W 247_G 1.704 1.00
196_N 230_H 1.686 1.00
210_Q 214_E 1.682 1.00
185_S 212_L 1.66 1.00
59_A 88_F 1.66 1.00
221_Y 246_K 1.647 1.00
208_I 212_L 1.644 1.00
109_H 115_D 1.611 1.00
74_L 87_L 1.576 1.00
197_L 225_L 1.567 1.00
137_F 282_P 1.556 1.00
151_V 197_L 1.554 1.00
101_E 154_S 1.546 1.00
200_N 205_V 1.532 1.00
213_L 222_L 1.499 1.00
150_K 154_S 1.495 1.00
195_I 225_L 1.495 1.00
52_L 83_P 1.482 1.00
233_E 254_N 1.475 1.00
198_L 230_H 1.466 1.00
161_P 190_Q 1.451 1.00
207_I 230_H 1.442 1.00
210_Q 235_D 1.441 1.00
237_L 241_D 1.429 1.00
73_K 82_N 1.424 1.00
106_Q 249_M 1.412 1.00
187_F 191_C 1.412 1.00
294_A 298_K 1.408 1.00
216_L 220_A 1.397 0.99
141_I 195_I 1.387 0.99
141_I 152_A 1.387 0.99
105_S 108_L 1.378 0.99
295_Q 303_C 1.376 0.99
142_L 194_L 1.374 0.99
226_A 230_H 1.368 0.99
291_R 295_Q 1.364 0.99
132_Y 137_F 1.359 0.99
97_E 135_E 1.356 0.99
212_L 215_K 1.35 0.99
86_P 305_Q 1.346 0.99
38_S 56_D 1.335 0.99
52_L 60_V 1.335 0.99
194_L 216_L 1.329 0.99
151_V 195_I 1.327 0.99
133_H 284_E 1.314 0.99
161_P 176_Q 1.31 0.99
103_A 151_V 1.301 0.99
40_D 56_D 1.29 0.99
205_V 229_V 1.289 0.99
108_L 158_W 1.288 0.99
217_P 220_A 1.279 0.99
95_M 278_A 1.279 0.99
234_D 263_P 1.267 0.99
185_S 211_Q 1.266 0.99
196_N 222_L 1.256 0.99
199_P 204_T 1.253 0.99
209_N 235_D 1.246 0.98
142_L 198_L 1.231 0.98
241_D 266_Q 1.231 0.98
71_L 75_Q 1.226 0.98
144_A 149_S 1.218 0.98
287_E 291_R 1.214 0.98
253_F 272_I 1.211 0.98
52_L 74_L 1.202 0.98
119_I 123_S 1.2 0.98
97_E 150_K 1.177 0.98
102_Y 106_Q 1.177 0.98
102_Y 273_T 1.151 0.97
110_W 271_T 1.149 0.97
103_A 225_L 1.146 0.97
193_V 221_Y 1.144 0.97
288_Y 304_G 1.138 0.97
62_A 69_S 1.13 0.97
142_L 207_I 1.127 0.97
72_S 82_N 1.119 0.96
49_V 73_K 1.118 0.96
153_Q 159_R 1.115 0.96
110_W 221_Y 1.107 0.96
59_A 296_L 1.106 0.96
53_A 73_K 1.099 0.96
163_R 191_C 1.098 0.96
233_E 255_R 1.094 0.96
219_G 245_V 1.093 0.96
41_Y 59_A 1.087 0.96
176_Q 190_Q 1.083 0.96
255_R 259_P 1.076 0.95
213_L 216_L 1.073 0.95
142_L 184_L 1.066 0.95
64_G 69_S 1.063 0.95
142_L 208_I 1.063 0.95
296_L 302_V 1.059 0.95
75_Q 307_D 1.056 0.95
142_L 196_N 1.054 0.95
48_P 51_M 1.05 0.94
233_E 262_S 1.045 0.94
219_G 244_K 1.041 0.94
240_L 270_V 1.039 0.94
61_F 292_T 1.035 0.94
100_Q 154_S 1.019 0.93
110_W 249_M 1.017 0.93
106_Q 271_T 1.017 0.93
184_L 188_L 1.016 0.93
138_T 191_C 1.014 0.93
209_N 232_V 1.014 0.93
200_N 204_T 1.014 0.93
208_I 222_L 1.01 0.93
198_L 207_I 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4n18A10.97441000.168Contact Map0.655
3pp8A10.99361000.195Contact Map0.698
3hg7A10.96791000.206Contact Map0.648
3evtA10.96791000.225Contact Map0.628
3ba1A10.94231000.243Contact Map0.76
1dxyA10.96471000.244Contact Map0.74
2pi1A40.96151000.244Contact Map0.839
3jtmA10.97121000.245Contact Map0.717
3k5pA10.96151000.249Contact Map0.782
2g76A20.92631000.251Contact Map0.824
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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