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OPENSEQ.org
GHRB - Glyoxylate/hydroxypyruvate reductase B
UniProt: P37666 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12272
Length: 324 (318)
Sequences: 8815
Seq/Len: 27.72
GHRB
Paralog alert: 0.88 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: GHRA GHRB LDHD SERA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
219_G 222_Q 4.67 1.00
242_D 245_A 3.934 1.00
220_A 248_A 3.633 1.00
148_L 164_A 2.892 1.00
195_D 225_K 2.791 1.00
228_S 254_E 2.764 1.00
147_T 171_P 2.584 1.00
251_Q 277_M 2.483 1.00
216_H 264_E 2.455 1.00
58_A 87_A 2.454 1.00
147_T 173_L 2.437 1.00
210_L 239_P 2.362 1.00
173_L 200_E 2.248 1.00
218_F 223_F 2.207 1.00
193_D 196_T 2.185 1.00
47_E 68_R 2.132 1.00
149_G 197_L 2.072 1.00
232_F 241_V 2.07 1.00
108_M 164_A 2.067 1.00
115_A 203_F 2.066 1.00
58_A 62_E 2.06 1.00
149_G 201_S 2.043 1.00
199_Q 225_K 2.042 1.00
198_L 222_Q 2.039 1.00
230_A 255_I 1.98 1.00
117_R 120_E 1.949 1.00
248_A 252_K 1.928 1.00
247_I 277_M 1.908 1.00
224_A 254_E 1.902 1.00
122_A 126_K 1.898 1.00
196_T 200_E 1.878 1.00
108_M 168_F 1.876 1.00
150_I 157_G 1.874 1.00
202_D 227_K 1.865 1.00
231_I 257_A 1.848 1.00
148_L 170_M 1.843 1.00
212_D 215_H 1.841 1.00
45_E 66_K 1.832 1.00
153_M 174_Y 1.829 1.00
159_A 162_Q 1.823 1.00
221_E 225_K 1.813 1.00
106_T 287_G 1.8 1.00
216_H 242_D 1.797 1.00
109_A 118_V 1.784 1.00
69_A 93_M 1.779 1.00
277_M 280_V 1.758 1.00
111_V 203_F 1.744 1.00
246_L 258_A 1.742 1.00
251_Q 273_P 1.73 1.00
171_P 190_R 1.722 1.00
307_D 312_K 1.716 1.00
223_F 249_A 1.7 1.00
164_A 170_M 1.698 1.00
195_D 222_Q 1.684 1.00
36_V 59_A 1.681 1.00
220_A 224_A 1.677 1.00
114_T 257_A 1.656 1.00
146_K 292_E 1.646 1.00
198_L 218_F 1.643 1.00
231_I 256_H 1.633 1.00
84_A 87_A 1.605 1.00
206_L 240_V 1.601 1.00
218_F 222_Q 1.599 1.00
113_S 119_V 1.582 1.00
62_E 88_R 1.579 1.00
105_D 163_R 1.517 1.00
160_L 207_I 1.497 1.00
210_L 215_H 1.497 1.00
159_A 163_R 1.476 1.00
223_F 232_F 1.46 1.00
171_P 200_E 1.456 1.00
61_L 88_R 1.448 1.00
207_I 235_A 1.445 1.00
110_L 259_G 1.43 1.00
217_L 240_V 1.427 1.00
35_T 38_Q 1.426 1.00
4_S 24_T 1.424 1.00
220_A 245_A 1.421 1.00
208_L 240_V 1.418 1.00
85_L 92_L 1.417 1.00
247_I 251_Q 1.416 1.00
36_V 57_N 1.41 1.00
205_C 235_A 1.406 0.99
226_M 230_A 1.401 0.99
243_E 264_E 1.395 0.99
197_L 201_S 1.389 0.99
306_I 310_Q 1.386 0.99
91_L 317_C 1.386 0.99
173_L 192_C 1.382 0.99
150_I 205_C 1.382 0.99
150_I 161_A 1.381 0.99
141_T 146_K 1.37 0.99
222_Q 225_K 1.368 0.99
83_D 87_A 1.36 0.99
13_D 17_Q 1.36 0.99
236_G 240_V 1.339 0.99
61_L 70_T 1.337 0.99
101_E 144_H 1.322 0.99
204_V 226_M 1.317 0.99
58_A 84_A 1.314 0.99
107_L 160_L 1.313 0.99
151_V 204_V 1.31 0.99
307_D 315_K 1.308 0.99
109_A 112_L 1.3 0.99
303_D 307_D 1.3 0.99
160_L 205_C 1.291 0.99
299_A 303_D 1.288 0.99
48_G 69_A 1.276 0.99
142_D 296_G 1.274 0.99
251_Q 276_S 1.274 0.99
47_E 66_K 1.267 0.99
86_T 319_N 1.262 0.99
215_H 239_P 1.257 0.99
112_L 168_F 1.255 0.99
123_E 127_A 1.252 0.99
195_D 221_E 1.246 0.98
26_H 46_A 1.231 0.98
227_K 230_A 1.222 0.98
190_R 200_E 1.217 0.98
80_F 85_L 1.215 0.98
244_N 273_P 1.21 0.98
84_A 88_R 1.209 0.98
151_V 208_L 1.199 0.98
61_L 85_L 1.192 0.98
209_P 214_T 1.192 0.98
206_L 232_F 1.189 0.98
265_Q 269_S 1.188 0.98
219_G 245_A 1.185 0.98
99_L 288_S 1.178 0.98
101_E 159_A 1.163 0.97
153_M 158_M 1.162 0.97
6_I 46_A 1.16 0.97
107_L 235_A 1.158 0.97
263_F 282_A 1.153 0.97
17_Q 21_E 1.15 0.97
17_Q 20_Q 1.146 0.97
114_T 231_I 1.143 0.97
72_T 80_F 1.136 0.97
173_L 201_S 1.131 0.97
151_V 217_L 1.13 0.97
62_E 84_A 1.129 0.97
106_T 110_L 1.12 0.96
114_T 281_V 1.119 0.96
162_Q 169_N 1.113 0.96
181_K 185_E 1.109 0.96
40_A 63_K 1.108 0.96
114_T 259_G 1.08 0.95
43_F 64_M 1.079 0.95
123_E 126_K 1.073 0.95
300_C 316_N 1.068 0.95
57_N 60_L 1.066 0.95
250_L 280_V 1.065 0.95
192_C 197_L 1.064 0.95
243_E 265_Q 1.064 0.95
106_T 283_V 1.061 0.95
72_T 79_N 1.06 0.95
147_T 201_S 1.054 0.95
203_F 231_I 1.049 0.94
249_A 254_E 1.039 0.94
249_A 255_I 1.032 0.94
218_F 232_F 1.032 0.94
151_V 194_L 1.032 0.94
194_L 198_L 1.028 0.94
219_G 242_D 1.026 0.94
151_V 218_F 1.02 0.93
244_N 248_A 1.017 0.93
104_A 163_R 1.017 0.93
69_A 308_A 1.015 0.93
308_A 314_E 1.013 0.93
208_L 217_L 1.012 0.93
38_Q 41_A 1.011 0.93
229_S 254_E 1.01 0.93
110_L 281_V 1.004 0.93
229_S 255_I 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4e5nA80.99071000.167Contact Map0.82
1ygyA20.97531000.174Contact Map0.78
4g2nA40.97531000.177Contact Map0.786
2d0iA40.98151000.181Contact Map0.86
3k5pA10.97221000.186Contact Map0.773
1sc6A40.97221000.189Contact Map0.809
2g76A20.95371000.19Contact Map0.817
2gcgA40.98461000.19Contact Map0.787
2dbqA10.99381000.191Contact Map0.846
3ba1A10.95371000.193Contact Map0.751
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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