| UniProt: | P62707 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11699 | ||
| Length: | 250 (246) | ||
| Sequences: | 2444 | ||
| Seq/Len: | 9.93 |
| GPMA
Paralog alert: 0.61 [within 20: 0.04] - ratio of genomes with paralogs Cluster includes: COBC GPMA GPMB |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 13_E | 33_K | 3.36 | 1.00 | |
| 9_V | 70_V | 3.036 | 1.00 | |
| 35_V | 65_H | 2.868 | 1.00 | |
| 43_K | 73_E | 2.631 | 1.00 | |
| 55_A | 67_L | 2.604 | 1.00 | |
| 53_D | 177_E | 2.438 | 1.00 | |
| 32_E | 35_V | 2.352 | 1.00 | |
| 29_D | 65_H | 2.215 | 1.00 | |
| 86_K | 167_E | 2.209 | 1.00 | |
| 54_F | 82_E | 2.184 | 1.00 | |
| 7_V | 52_F | 2.127 | 1.00 | |
| 29_D | 61_K | 2.042 | 1.00 | |
| 237_A | 241_A | 2.004 | 1.00 | |
| 152_E | 160_R | 1.998 | 1.00 | |
| 5_K | 217_E | 1.99 | 1.00 | |
| 15_Q | 19_E | 1.967 | 1.00 | |
| 56_Y | 172_R | 1.963 | 1.00 | |
| 125_E | 151_T | 1.921 | 1.00 | |
| 219_D | 223_K | 1.824 | 1.00 | |
| 55_A | 71_L | 1.816 | 1.00 | |
| 153_S | 156_L | 1.813 | 1.00 | |
| 64_I | 83_K | 1.782 | 1.00 | |
| 162_I | 194_Y | 1.781 | 1.00 | |
| 39_K | 69_N | 1.737 | 1.00 | |
| 128_K | 150_L | 1.734 | 1.00 | |
| 234_D | 237_A | 1.732 | 1.00 | |
| 101_A | 105_E | 1.71 | 1.00 | |
| 39_K | 73_E | 1.703 | 1.00 | |
| 35_V | 69_N | 1.692 | 1.00 | |
| 5_K | 178_R | 1.678 | 1.00 | |
| 35_V | 39_K | 1.653 | 1.00 | |
| 59_V | 88_N | 1.652 | 1.00 | |
| 36_S | 39_K | 1.649 | 1.00 | |
| 98_L | 106_K | 1.648 | 1.00 | |
| 199_S | 202_E | 1.646 | 1.00 | |
| 155_A | 159_D | 1.641 | 1.00 | |
| 183_A | 187_S | 1.641 | 1.00 | |
| 86_K | 163_P | 1.637 | 1.00 | |
| 192_V | 208_I | 1.636 | 1.00 | |
| 38_A | 66_T | 1.618 | 1.00 | |
| 196_D | 216_Y | 1.615 | 1.00 | |
| 54_F | 179_V | 1.602 | 1.00 | |
| 193_K | 200_E | 1.578 | 1.00 | |
| 37_E | 210_T | 1.569 | 1.00 | |
| 5_K | 215_V | 1.562 | 1.00 | |
| 126_L | 130_D | 1.558 | 1.00 | |
| 40_A | 43_K | 1.538 | 1.00 | |
| 56_Y | 164_Y | 1.538 | 1.00 | |
| 241_A | 245_N | 1.513 | 1.00 | |
| 170_L | 222_F | 1.505 | 1.00 | |
| 198_M | 202_E | 1.495 | 1.00 | |
| 119_F | 158_I | 1.492 | 1.00 | |
| 172_R | 177_E | 1.488 | 1.00 | |
| 53_D | 178_R | 1.485 | 1.00 | |
| 245_N | 248_K | 1.483 | 1.00 | |
| 126_L | 132_R | 1.476 | 1.00 | |
| 162_I | 166_N | 1.429 | 1.00 | |
| 68_W | 77_A | 1.429 | 1.00 | |
| 13_E | 31_S | 1.426 | 1.00 | |
| 144_S | 147_E | 1.422 | 1.00 | |
| 156_L | 159_D | 1.397 | 0.99 | |
| 43_K | 47_E | 1.393 | 0.99 | |
| 9_V | 180_I | 1.386 | 0.99 | |
| 33_K | 36_S | 1.38 | 0.99 | |
| 120_A | 155_A | 1.366 | 0.99 | |
| 233_A | 236_I | 1.354 | 0.99 | |
| 51_S | 76_Q | 1.334 | 0.99 | |
| 101_A | 104_A | 1.331 | 0.99 | |
| 198_M | 203_I | 1.328 | 0.99 | |
| 231_G | 236_I | 1.315 | 0.99 | |
| 52_F | 180_I | 1.313 | 0.99 | |
| 23_T | 28_V | 1.307 | 0.99 | |
| 129_D | 135_G | 1.275 | 0.99 | |
| 23_T | 210_T | 1.271 | 0.99 | |
| 55_A | 79_L | 1.266 | 0.99 | |
| 217_E | 228_Y | 1.255 | 0.99 | |
| 32_E | 36_S | 1.252 | 0.99 | |
| 86_K | 164_Y | 1.249 | 0.99 | |
| 122_T | 156_L | 1.242 | 0.98 | |
| 236_I | 240_A | 1.241 | 0.98 | |
| 9_V | 41_A | 1.239 | 0.98 | |
| 58_S | 184_H | 1.222 | 0.98 | |
| 133_Y | 136_H | 1.215 | 0.98 | |
| 65_H | 68_W | 1.213 | 0.98 | |
| 13_E | 18_K | 1.207 | 0.98 | |
| 234_D | 238_A | 1.205 | 0.98 | |
| 33_K | 37_E | 1.202 | 0.98 | |
| 42_G | 73_E | 1.185 | 0.98 | |
| 241_A | 244_A | 1.174 | 0.98 | |
| 63_A | 184_H | 1.152 | 0.97 | |
| 128_K | 133_Y | 1.132 | 0.97 | |
| 129_D | 133_Y | 1.124 | 0.97 | |
| 52_F | 178_R | 1.122 | 0.96 | |
| 183_A | 188_L | 1.118 | 0.96 | |
| 4_T | 220_E | 1.108 | 0.96 | |
| 128_K | 145_E | 1.104 | 0.96 | |
| 113_K | 205_E | 1.102 | 0.96 | |
| 57_T | 83_K | 1.101 | 0.96 | |
| 214_L | 229_Y | 1.1 | 0.96 | |
| 243_V | 246_Q | 1.095 | 0.96 | |
| 8_L | 191_L | 1.092 | 0.96 | |
| 31_S | 34_G | 1.091 | 0.96 | |
| 16_W | 23_T | 1.091 | 0.96 | |
| 188_L | 208_I | 1.09 | 0.96 | |
| 52_F | 76_Q | 1.089 | 0.96 | |
| 133_Y | 150_L | 1.086 | 0.96 | |
| 168_T | 181_I | 1.086 | 0.96 | |
| 127_T | 135_G | 1.076 | 0.95 | |
| 17_N | 210_T | 1.075 | 0.95 | |
| 39_K | 72_D | 1.064 | 0.95 | |
| 48_E | 228_Y | 1.058 | 0.95 | |
| 16_W | 28_V | 1.056 | 0.95 | |
| 238_A | 241_A | 1.052 | 0.94 | |
| 68_W | 81_V | 1.051 | 0.94 | |
| 15_Q | 31_S | 1.042 | 0.94 | |
| 58_S | 63_A | 1.042 | 0.94 | |
| 16_W | 21_R | 1.041 | 0.94 | |
| 208_I | 229_Y | 1.031 | 0.94 | |
| 233_A | 237_A | 1.028 | 0.94 | |
| 56_Y | 82_E | 1.028 | 0.94 | |
| 7_V | 178_R | 1.022 | 0.93 | |
| 57_T | 64_I | 1.016 | 0.93 | |
| 240_A | 245_N | 1.013 | 0.93 | |
| 128_K | 135_G | 1.01 | 0.93 | |
| 161_V | 187_S | 1.009 | 0.93 | |
| 130_D | 133_Y | 1.008 | 0.93 | |
| 8_L | 188_L | 1.006 | 0.93 | |
| 55_A | 180_I | 1.005 | 0.93 | |
| 45_L | 50_Y | 1.005 | 0.93 | |
| 65_H | 77_A | 1.002 | 0.92 | |
| 12_G | 30_L | 1.001 | 0.92 | |
| 224_P | 227_R | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2hhjA | 2 | 1 | 100 | 0.202 | Contact Map | 0.843 |
| 4gpzA | 2 | 1 | 100 | 0.204 | Contact Map | 0.863 |
| 1riiA | 4 | 0.988 | 100 | 0.216 | Contact Map | 0.813 |
| 3kkkA | 4 | 1 | 100 | 0.218 | Contact Map | 0.916 |
| 3gp3A | 4 | 1 | 100 | 0.22 | Contact Map | 0.871 |
| 3d8hA | 2 | 1 | 100 | 0.225 | Contact Map | 0.843 |
| 4embA | 4 | 1 | 100 | 0.228 | Contact Map | 0.792 |
| 1e58A | 1 | 0.996 | 100 | 0.229 | Contact Map | 0.738 |
| 1qhfA | 2 | 0.956 | 100 | 0.281 | Contact Map | 0.803 |
| 4eo9A | 1 | 0.968 | 100 | 0.286 | Contact Map | 0.793 |
Sequence Conservation (Image Generated using WebLogo v3)