| UniProt: | P52086 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13240 | ||
| Length: | 203 (197) | ||
| Sequences: | 6644 | ||
| Seq/Len: | 33.73 |
| COBC
Paralog alert: 0.82 [within 20: 0.08] - ratio of genomes with paralogs Cluster includes: COBC GPMA GPMB |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 10_E | 30_R | 3.144 | 1.00 | |
| 32_I | 60_H | 3.143 | 1.00 | |
| 54_E | 80_N | 3.079 | 1.00 | |
| 86_D | 117_N | 2.977 | 1.00 | |
| 78_E | 134_R | 2.869 | 1.00 | |
| 78_E | 130_R | 2.61 | 1.00 | |
| 59_Q | 75_I | 2.392 | 1.00 | |
| 2_R | 180_A | 2.329 | 1.00 | |
| 129_E | 159_R | 2.306 | 1.00 | |
| 36_Q | 64_L | 2.296 | 1.00 | |
| 78_E | 131_F | 2.189 | 1.00 | |
| 49_L | 74_Q | 2.175 | 1.00 | |
| 26_P | 56_E | 2.137 | 1.00 | |
| 128_V | 152_V | 2.118 | 1.00 | |
| 148_S | 152_V | 2.057 | 1.00 | |
| 26_P | 60_H | 2.052 | 1.00 | |
| 32_I | 64_L | 2.051 | 1.00 | |
| 10_E | 28_T | 2.033 | 1.00 | |
| 60_H | 63_R | 2.032 | 1.00 | |
| 6_I | 38_L | 2.032 | 1.00 | |
| 50_V | 62_A | 1.997 | 1.00 | |
| 2_R | 143_N | 1.99 | 1.00 | |
| 90_R | 98_E | 1.989 | 1.00 | |
| 6_I | 65_V | 1.956 | 1.00 | |
| 50_V | 66_L | 1.954 | 1.00 | |
| 119_E | 127_R | 1.943 | 1.00 | |
| 6_I | 145_L | 1.867 | 1.00 | |
| 79_L | 131_F | 1.819 | 1.00 | |
| 48_D | 142_Q | 1.797 | 1.00 | |
| 12_Q | 28_T | 1.778 | 1.00 | |
| 29_A | 32_I | 1.778 | 1.00 | |
| 2_R | 182_D | 1.777 | 1.00 | |
| 120_G | 123_A | 1.758 | 1.00 | |
| 4_W | 47_F | 1.728 | 1.00 | |
| 12_Q | 16_D | 1.681 | 1.00 | |
| 54_E | 77_P | 1.664 | 1.00 | |
| 59_Q | 63_R | 1.646 | 1.00 | |
| 32_I | 36_Q | 1.642 | 1.00 | |
| 22_H | 83_F | 1.629 | 1.00 | |
| 148_S | 153_L | 1.623 | 1.00 | |
| 40_T | 68_D | 1.595 | 1.00 | |
| 35_A | 61_T | 1.592 | 1.00 | |
| 33_E | 36_Q | 1.584 | 1.00 | |
| 22_H | 80_N | 1.561 | 1.00 | |
| 47_F | 145_L | 1.531 | 1.00 | |
| 33_E | 37_N | 1.477 | 1.00 | |
| 51_L | 131_F | 1.454 | 1.00 | |
| 48_D | 143_N | 1.445 | 1.00 | |
| 65_V | 147_V | 1.442 | 1.00 | |
| 153_L | 173_V | 1.438 | 1.00 | |
| 4_W | 143_N | 1.431 | 1.00 | |
| 190_L | 193_L | 1.421 | 1.00 | |
| 91_H | 94_D | 1.418 | 1.00 | |
| 52_C | 75_I | 1.401 | 0.99 | |
| 13_A | 18_L | 1.393 | 0.99 | |
| 123_A | 126_Q | 1.376 | 0.99 | |
| 76_I | 131_F | 1.353 | 0.99 | |
| 40_T | 43_H | 1.347 | 0.99 | |
| 122_Q | 126_Q | 1.346 | 0.99 | |
| 192_V | 195_S | 1.336 | 0.99 | |
| 30_R | 33_E | 1.329 | 0.99 | |
| 114_I | 123_A | 1.329 | 0.99 | |
| 109_D | 112_H | 1.327 | 0.99 | |
| 128_V | 156_L | 1.315 | 0.99 | |
| 30_R | 34_Q | 1.313 | 0.99 | |
| 37_N | 40_T | 1.309 | 0.99 | |
| 49_L | 142_Q | 1.308 | 0.99 | |
| 76_I | 134_R | 1.304 | 0.99 | |
| 13_A | 20_S | 1.297 | 0.99 | |
| 174_D | 194_N | 1.289 | 0.99 | |
| 180_A | 192_V | 1.273 | 0.99 | |
| 23_A | 88_E | 1.244 | 0.98 | |
| 36_Q | 67_S | 1.239 | 0.98 | |
| 28_T | 31_G | 1.238 | 0.98 | |
| 10_E | 15_I | 1.237 | 0.98 | |
| 182_D | 191_R | 1.235 | 0.98 | |
| 129_E | 133_A | 1.226 | 0.98 | |
| 83_F | 88_E | 1.205 | 0.98 | |
| 29_A | 33_E | 1.184 | 0.98 | |
| 90_R | 94_D | 1.164 | 0.97 | |
| 14_N | 175_Q | 1.153 | 0.97 | |
| 4_W | 180_A | 1.147 | 0.97 | |
| 51_L | 139_Q | 1.142 | 0.97 | |
| 51_L | 74_Q | 1.139 | 0.97 | |
| 52_C | 73_V | 1.119 | 0.96 | |
| 11_T | 20_S | 1.113 | 0.96 | |
| 22_H | 54_E | 1.105 | 0.96 | |
| 63_R | 67_S | 1.099 | 0.96 | |
| 20_S | 25_T | 1.098 | 0.96 | |
| 87_W | 95_L | 1.094 | 0.96 | |
| 13_A | 25_T | 1.085 | 0.96 | |
| 52_C | 59_Q | 1.066 | 0.95 | |
| 124_F | 152_V | 1.061 | 0.95 | |
| 131_F | 146_V | 1.051 | 0.94 | |
| 36_Q | 68_D | 1.04 | 0.94 | |
| 53_S | 149_H | 1.038 | 0.94 | |
| 5_L | 153_L | 1.035 | 0.94 | |
| 41_L | 195_S | 1.031 | 0.94 | |
| 164_P | 167_A | 1.029 | 0.94 | |
| 93_R | 97_Q | 1.025 | 0.93 | |
| 52_C | 58_A | 1.019 | 0.93 | |
| 47_F | 143_N | 1.019 | 0.93 | |
| 39_H | 64_L | 1.015 | 0.93 | |
| 11_T | 175_Q | 1.006 | 0.93 | |
| 66_L | 73_V | 1.004 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4ij5A | 2 | 1 | 100 | 0.101 | Contact Map | 0.819 |
| 1h2eA | 1 | 1 | 100 | 0.118 | Contact Map | 0.807 |
| 3gp3A | 4 | 1 | 100 | 0.145 | Contact Map | 0.802 |
| 4embA | 4 | 1 | 100 | 0.152 | Contact Map | 0.743 |
| 1e58A | 1 | 1 | 100 | 0.152 | Contact Map | 0.735 |
| 3kkkA | 4 | 1 | 100 | 0.155 | Contact Map | 0.84 |
| 3d8hA | 2 | 1 | 100 | 0.16 | Contact Map | 0.792 |
| 4gpzA | 2 | 1 | 100 | 0.162 | Contact Map | 0.804 |
| 3r7aA | 2 | 0.9704 | 100 | 0.167 | Contact Map | 0.755 |
| 2hhjA | 2 | 1 | 100 | 0.168 | Contact Map | 0.767 |
Sequence Conservation (Image Generated using WebLogo v3)