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OPENSEQ.org

GPMB - Probable phosphoglycerate mutase GpmB
UniProt: P0A7A2 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12164
Length: 215 (201)
Sequences: 6205
Seq/Len: 30.87

GPMB
Paralog alert: 0.80 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: COBC GPMA GPMB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
33_E 61_R 3.18 1.00
11_E 31_K 3.15 1.00
87_V 118_E 3.018 1.00
55_D 81_R 2.996 1.00
79_R 135_S 2.901 1.00
79_R 131_A 2.632 1.00
3_Q 181_R 2.428 1.00
60_R 76_F 2.413 1.00
50_H 75_I 2.322 1.00
37_M 65_I 2.242 1.00
130_N 160_T 2.215 1.00
27_P 57_G 2.201 1.00
79_R 132_A 2.197 1.00
51_I 63_A 2.132 1.00
129_V 153_A 2.122 1.00
149_S 153_A 2.1 1.00
33_E 65_I 2.094 1.00
91_R 99_E 2.075 1.00
7_V 66_I 2.061 1.00
61_R 64_E 2.045 1.00
3_Q 144_R 2.044 1.00
7_V 39_V 2.008 1.00
27_P 61_R 1.977 1.00
11_E 29_T 1.963 1.00
7_V 146_L 1.871 1.00
80_L 132_A 1.87 1.00
5_Y 48_I 1.852 1.00
30_A 33_E 1.819 1.00
13_Q 29_T 1.816 1.00
3_Q 183_D 1.802 1.00
51_I 67_A 1.792 1.00
49_T 143_S 1.779 1.00
121_S 124_E 1.776 1.00
13_Q 17_E 1.738 1.00
48_I 146_L 1.73 1.00
120_E 128_R 1.721 1.00
36_A 62_T 1.675 1.00
60_R 64_E 1.626 1.00
23_Q 81_R 1.624 1.00
23_Q 84_N 1.623 1.00
33_E 37_M 1.61 1.00
41_T 69_A 1.57 1.00
55_D 78_S 1.547 1.00
149_S 154_L 1.538 1.00
66_I 148_V 1.526 1.00
34_Q 37_M 1.51 1.00
124_E 127_D 1.497 1.00
49_T 144_R 1.492 1.00
50_H 143_S 1.491 1.00
154_L 174_L 1.485 1.00
92_H 95_S 1.465 1.00
115_R 124_E 1.462 1.00
53_S 76_F 1.435 1.00
5_Y 144_R 1.427 1.00
34_Q 38_Q 1.423 1.00
196_V 199_A 1.421 1.00
52_I 132_A 1.414 1.00
31_K 34_Q 1.412 1.00
77_D 132_A 1.36 0.99
14_W 19_R 1.356 0.99
123_Q 127_D 1.349 0.99
84_N 89_E 1.331 0.99
183_D 197_E 1.329 0.99
198_T 201_D 1.303 0.99
14_W 21_Q 1.301 0.99
15_N 176_N 1.297 0.99
41_T 44_K 1.289 0.99
130_N 134_E 1.286 0.99
31_K 35_Q 1.276 0.99
129_V 157_L 1.254 0.99
37_M 68_Q 1.254 0.99
11_E 16_A 1.249 0.99
5_Y 181_R 1.243 0.98
77_D 135_S 1.23 0.98
12_T 21_Q 1.218 0.98
38_Q 41_T 1.206 0.98
91_R 95_S 1.196 0.98
42_R 201_D 1.183 0.98
110_G 113_D 1.177 0.98
175_R 200_G 1.177 0.98
52_I 140_P 1.172 0.98
29_T 32_G 1.169 0.97
24_S 89_E 1.154 0.97
181_R 198_T 1.148 0.97
30_A 34_Q 1.14 0.97
21_Q 26_S 1.135 0.97
64_E 68_Q 1.111 0.96
52_I 75_I 1.107 0.96
6_L 154_L 1.104 0.96
125_L 153_A 1.1 0.96
54_S 150_H 1.094 0.96
12_T 176_N 1.087 0.96
88_L 96_L 1.084 0.96
132_A 147_L 1.076 0.95
10_G 28_L 1.065 0.95
80_L 147_L 1.065 0.95
53_S 74_I 1.06 0.95
105_R 109_N 1.059 0.95
53_S 60_R 1.035 0.94
14_W 26_S 1.033 0.94
23_Q 55_D 1.032 0.94
35_Q 176_N 1.017 0.93
40_A 65_I 1.009 0.93
7_V 179_I 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ij5A20.97211000.126Contact Map0.829
1h2eA10.95351000.144Contact Map0.806
3gp3A40.98141000.169Contact Map0.804
1e58A10.98141000.174Contact Map0.739
3d8hA20.98141000.181Contact Map0.795
3kkkA40.98141000.181Contact Map0.84
4embA40.97211000.182Contact Map0.746
4gpzA20.97671000.194Contact Map0.816
2hhjA20.97671000.198Contact Map0.766
3r7aA20.93491000.2Contact Map0.751

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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