OPENSEQ.org - FLAV - ECOLI GREMLIN

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FLAV - Flavodoxin-1

UniProt:	P61949	Sequence MAITGIFFGSDTGNTENIAKMIQKQLGKDVADVHDIAKSSKEDLEAYDILLLGIPTWYYGEAQCDWDDFFPTLEEIDFNGKLVALFGCGDQEDYAEYFCDALGTIRDIIEPRGATIVGHWPTAGYHFEASKGLADDDHFVGLAIDEDRQPELTAERVEKWVKQISEELHLDEILNA	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG10318
Length:	176 (168)
Sequences:	1997
Seq/Len:	11.89

FLAV
Paralog alert: 0.64 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: FLAV FLAW MIOC YQCA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
87_G	102_L	4.206	1.00
106_R	116_I	3.79	1.00
82_L	115_T	3.446	1.00
108_I	112_R	2.683	1.00
11_D	64_C	2.661	1.00
108_I	111_P	2.356	1.00
110_E	116_I	2.18	1.00
16_E	20_K	2.171	1.00
90_D	93_D	1.955	1.00
100_D	104_T	1.95	1.00
83_V	110_E	1.947	1.00
36_I	69_F	1.934	1.00
85_L	102_L	1.854	1.00
23_Q	33_V	1.834	1.00
127_F	133_L	1.765	1.00
120_W	142_L	1.744	1.00
26_L	165_S	1.639	1.00
83_V	106_R	1.627	1.00
4_T	26_L	1.557	1.00
9_G	54_I	1.538	1.00
106_R	110_E	1.538	1.00
162_K	166_E	1.536	1.00
35_D	38_K	1.532	1.00
153_T	156_R	1.52	1.00
54_I	105_I	1.513	1.00
39_S	47_Y	1.508	1.00
103_G	142_L	1.496	1.00
32_D	47_Y	1.482	1.00
80_G	115_T	1.47	1.00
10_S	65_D	1.467	1.00
7_F	36_I	1.455	1.00
53_G	86_F	1.451	1.00
9_G	66_W	1.439	1.00
23_Q	27_G	1.434	1.00
9_G	65_D	1.407	0.99
74_E	108_I	1.404	0.99
51_L	164_I	1.389	0.99
83_V	116_I	1.388	0.99
122_T	133_L	1.384	0.99
86_F	143_A	1.382	0.99
61_E	104_T	1.375	0.99
16_E	65_D	1.35	0.99
118_G	163_Q	1.323	0.99
10_S	15_T	1.302	0.99
7_F	39_S	1.294	0.99
6_I	23_Q	1.278	0.99
109_I	114_A	1.266	0.99
58_Y	61_E	1.259	0.99
5_G	34_H	1.25	0.99
62_A	101_A	1.245	0.98
21_M	154_A	1.234	0.98
6_I	31_A	1.208	0.98
157_V	161_V	1.199	0.98
43_D	46_A	1.189	0.98
86_F	141_G	1.184	0.98
156_R	160_W	1.181	0.98
40_S	43_D	1.168	0.97
20_K	33_V	1.168	0.97
49_I	82_L	1.147	0.97
76_I	112_R	1.139	0.97
52_L	109_I	1.135	0.97
109_I	116_I	1.108	0.96
84_A	118_G	1.101	0.96
23_Q	31_A	1.101	0.96
22_I	53_G	1.101	0.96
155_E	159_K	1.093	0.96
119_H	163_Q	1.093	0.96
25_Q	158_E	1.092	0.96
18_I	157_V	1.086	0.96
51_L	84_A	1.085	0.96
50_L	81_K	1.078	0.95
39_S	72_T	1.071	0.95
15_T	53_G	1.064	0.95
70_F	105_I	1.039	0.94
22_I	161_V	1.038	0.94
123_A	137_D	1.035	0.94
70_F	104_T	1.034	0.94
67_D	71_P	1.03	0.94
5_G	50_L	1.026	0.94
163_Q	167_E	1.016	0.93
142_L	145_D	1.014	0.93
81_K	109_I	1.01	0.93
6_I	22_I	1.003	0.93
121_P	137_D	1.002	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
1tllA	2	0.8523	100	0.344	Contact Map	0.766
1ag9A	2	0.9943	100	0.348	Contact Map	0.735
2wc1A	1	0.983	100	0.356	Contact Map	0.605
1yobA	2	0.9659	100	0.371	Contact Map	0.644
2bpoA	2	0.858	100	0.374	Contact Map	0.689
3qe2A	2	0.8523	100	0.374	Contact Map	0.79
2bmvA	1	0.9261	100	0.383	Contact Map	0.672
1oboA	2	0.9545	100	0.413	Contact Map	0.716
2fcrA	1	0.9432	100	0.419	Contact Map	0.564
3hr4A	4	0.8523	100	0.422	Contact Map	0.853

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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