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OPENSEQ.org
FLAW - Flavodoxin-2
UniProt: P0ABY4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12697
Length: 173 (170)
Sequences: 2011
Seq/Len: 11.83
FLAW
Paralog alert: 0.63 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: FLAV FLAW MIOC YQCA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
86_G 101_L 4.069 1.00
105_H 115_F 3.763 1.00
81_I 114_K 3.619 1.00
107_K 111_K 2.789 1.00
10_S 63_E 2.586 1.00
107_K 110_T 2.332 1.00
109_S 115_F 2.261 1.00
99_D 103_M 2.094 1.00
15_E 19_E 2.042 1.00
35_L 68_V 1.99 1.00
82_V 109_S 1.97 1.00
22_R 32_L 1.962 1.00
119_W 142_L 1.947 1.00
84_L 101_L 1.871 1.00
25_I 165_L 1.825 1.00
126_F 132_V 1.794 1.00
89_D 92_G 1.773 1.00
3_M 25_I 1.631 1.00
8_G 53_I 1.613 1.00
38_D 46_Y 1.56 1.00
8_G 64_D 1.556 1.00
5_L 22_R 1.534 1.00
153_S 156_R 1.483 1.00
52_G 85_Y 1.477 1.00
50_I 164_I 1.475 1.00
9_S 64_D 1.459 1.00
34_N 37_D 1.445 1.00
82_V 105_H 1.443 1.00
8_G 65_W 1.411 1.00
102_G 142_L 1.404 0.99
48_V 168_M 1.4 0.99
53_I 104_L 1.398 0.99
15_E 64_D 1.394 0.99
31_T 46_Y 1.392 0.99
73_D 107_K 1.388 0.99
121_T 132_V 1.382 0.99
20_K 154_D 1.376 0.99
21_I 52_G 1.367 0.99
117_G 163_Q 1.354 0.99
162_E 166_N 1.353 0.99
9_S 14_T 1.346 0.99
105_H 109_S 1.344 0.99
22_R 26_G 1.34 0.99
79_G 114_K 1.34 0.99
6_F 35_L 1.338 0.99
60_E 103_M 1.269 0.99
85_Y 143_A 1.248 0.99
51_L 108_L 1.248 0.99
57_D 60_E 1.246 0.98
4_G 33_H 1.246 0.98
82_V 115_F 1.243 0.98
6_F 38_D 1.238 0.98
108_L 113_V 1.237 0.98
83_A 117_G 1.228 0.98
24_I 158_Q 1.227 0.98
42_L 45_Q 1.22 0.98
61_I 100_A 1.19 0.98
49_L 80_K 1.147 0.97
17_A 157_I 1.141 0.97
5_L 30_V 1.137 0.97
155_E 159_S 1.136 0.97
102_G 143_A 1.135 0.97
142_L 145_D 1.126 0.97
157_I 161_C 1.121 0.97
48_V 81_I 1.111 0.96
6_F 49_L 1.107 0.96
14_T 52_G 1.1 0.96
22_R 30_V 1.09 0.96
4_G 46_Y 1.088 0.96
85_Y 141_G 1.083 0.96
21_I 161_C 1.074 0.95
4_G 31_T 1.073 0.95
141_G 144_L 1.067 0.95
108_L 115_F 1.053 0.95
4_G 49_L 1.05 0.94
163_Q 167_E 1.048 0.94
39_S 42_L 1.042 0.94
19_E 32_L 1.036 0.94
66_E 70_D 1.035 0.94
54_P 62_Q 1.03 0.94
38_D 71_Q 1.029 0.94
85_Y 157_I 1.028 0.94
17_A 52_G 1.019 0.93
120_P 137_Q 1.006 0.93
159_S 163_Q 1.005 0.93
36_K 67_A 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1tllA20.84391000.298Contact Map0.796
3qe2A20.84391000.327Contact Map0.807
2wc1A10.98841000.329Contact Map0.596
2bpoA20.84971000.331Contact Map0.683
1ag9A20.98841000.333Contact Map0.734
1yobA20.98271000.337Contact Map0.625
2bmvA10.93641000.371Contact Map0.659
3hr4A40.84391000.377Contact Map0.872
1oboA20.97111000.392Contact Map0.696
2fcrA10.95951000.4Contact Map0.558
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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