| UniProt: | P40874 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12669 | ||
| Length: | 372 (370) | ||
| Sequences: | 11088 | ||
| Seq/Len: | 29.97 |
| MTOX
Paralog alert: 0.81 [within 20: 0.13] - ratio of genomes with paralogs Cluster includes: DADA LHGO MTOX PUUB |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 159_A | 164_C | 4.946 | 1.00 | |
| 3_Y | 29_L | 3.886 | 1.00 | |
| 33_A | 171_P | 3.673 | 1.00 | |
| 6_I | 184_I | 3.66 | 1.00 | |
| 4_D | 194_K | 3.448 | 1.00 | |
| 118_D | 121_G | 3.244 | 1.00 | |
| 171_P | 187_A | 3.161 | 1.00 | |
| 174_A | 185_E | 2.946 | 1.00 | |
| 6_I | 193_A | 2.86 | 1.00 | |
| 66_R | 348_E | 2.803 | 1.00 | |
| 4_D | 27_N | 2.759 | 1.00 | |
| 6_I | 31_T | 2.721 | 1.00 | |
| 72_D | 86_R | 2.702 | 1.00 | |
| 122_I | 137_G | 2.678 | 1.00 | |
| 115_E | 121_G | 2.67 | 1.00 | |
| 23_R | 77_H | 2.609 | 1.00 | |
| 29_L | 167_L | 2.592 | 1.00 | |
| 22_T | 162_A | 2.583 | 1.00 | |
| 121_G | 124_A | 2.566 | 1.00 | |
| 27_N | 165_A | 2.436 | 1.00 | |
| 97_S | 136_I | 2.406 | 1.00 | |
| 31_T | 191_Y | 2.382 | 1.00 | |
| 17_A | 197_I | 2.331 | 1.00 | |
| 5_L | 21_A | 2.324 | 1.00 | |
| 176_R | 185_E | 2.282 | 1.00 | |
| 5_L | 26_L | 2.183 | 1.00 | |
| 26_L | 355_Q | 2.147 | 1.00 | |
| 6_I | 191_Y | 2.128 | 1.00 | |
| 73_E | 77_H | 2.119 | 1.00 | |
| 22_T | 164_C | 2.038 | 1.00 | |
| 185_E | 190_E | 2.016 | 1.00 | |
| 335_L | 346_L | 1.995 | 1.00 | |
| 352_D | 357_K | 1.99 | 1.00 | |
| 15_A | 152_I | 1.985 | 1.00 | |
| 115_E | 141_T | 1.972 | 1.00 | |
| 172_V | 184_I | 1.942 | 1.00 | |
| 286_S | 290_P | 1.925 | 1.00 | |
| 195_K | 330_L | 1.923 | 1.00 | |
| 332_I | 346_L | 1.902 | 1.00 | |
| 197_I | 354_A | 1.883 | 1.00 | |
| 15_A | 156_I | 1.877 | 1.00 | |
| 178_D | 183_T | 1.844 | 1.00 | |
| 19_Y | 158_L | 1.838 | 1.00 | |
| 173_T | 185_E | 1.82 | 1.00 | |
| 105_H | 108_E | 1.815 | 1.00 | |
| 20_Y | 348_E | 1.796 | 1.00 | |
| 352_D | 360_D | 1.782 | 1.00 | |
| 19_Y | 23_R | 1.775 | 1.00 | |
| 10_S | 30_M | 1.766 | 1.00 | |
| 23_R | 162_A | 1.754 | 1.00 | |
| 83_I | 150_L | 1.723 | 1.00 | |
| 117_L | 121_G | 1.72 | 1.00 | |
| 330_L | 350_A | 1.705 | 1.00 | |
| 119_A | 123_M | 1.704 | 1.00 | |
| 3_Y | 165_A | 1.688 | 1.00 | |
| 71_W | 151_A | 1.685 | 1.00 | |
| 198_V | 204_V | 1.682 | 1.00 | |
| 101_A | 116_K | 1.681 | 1.00 | |
| 330_L | 354_A | 1.675 | 1.00 | |
| 10_S | 32_D | 1.673 | 1.00 | |
| 105_H | 109_Q | 1.671 | 1.00 | |
| 10_S | 36_P | 1.669 | 1.00 | |
| 120_Q | 124_A | 1.664 | 1.00 | |
| 332_I | 350_A | 1.662 | 1.00 | |
| 104_A | 108_E | 1.66 | 1.00 | |
| 218_K | 310_Y | 1.655 | 1.00 | |
| 158_L | 161_E | 1.654 | 1.00 | |
| 20_Y | 347_G | 1.65 | 1.00 | |
| 176_R | 183_T | 1.647 | 1.00 | |
| 157_Q | 160_K | 1.642 | 1.00 | |
| 113_N | 142_D | 1.599 | 1.00 | |
| 16_A | 20_Y | 1.595 | 1.00 | |
| 22_T | 159_A | 1.591 | 1.00 | |
| 29_L | 191_Y | 1.586 | 1.00 | |
| 156_I | 166_Q | 1.581 | 1.00 | |
| 167_L | 170_C | 1.569 | 1.00 | |
| 24_A | 355_Q | 1.567 | 1.00 | |
| 88_G | 139_F | 1.535 | 1.00 | |
| 186_T | 189_G | 1.534 | 1.00 | |
| 183_T | 190_E | 1.512 | 1.00 | |
| 20_Y | 24_A | 1.511 | 1.00 | |
| 347_G | 351_A | 1.51 | 1.00 | |
| 24_A | 351_A | 1.507 | 1.00 | |
| 24_A | 357_K | 1.505 | 1.00 | |
| 204_V | 333_T | 1.499 | 1.00 | |
| 24_A | 352_D | 1.499 | 1.00 | |
| 183_T | 192_Q | 1.496 | 1.00 | |
| 36_P | 156_I | 1.494 | 1.00 | |
| 3_Y | 6_I | 1.493 | 1.00 | |
| 195_K | 354_A | 1.491 | 1.00 | |
| 6_I | 29_L | 1.482 | 1.00 | |
| 31_T | 172_V | 1.459 | 1.00 | |
| 13_V | 332_I | 1.447 | 1.00 | |
| 175_I | 196_A | 1.447 | 1.00 | |
| 315_D | 370_R | 1.432 | 1.00 | |
| 13_V | 335_L | 1.425 | 1.00 | |
| 282_A | 286_S | 1.423 | 1.00 | |
| 158_L | 162_A | 1.415 | 1.00 | |
| 18_G | 28_V | 1.401 | 0.99 | |
| 193_A | 196_A | 1.399 | 0.99 | |
| 15_A | 159_A | 1.395 | 0.99 | |
| 7_I | 18_G | 1.395 | 0.99 | |
| 70_L | 348_E | 1.39 | 0.99 | |
| 198_V | 329_T | 1.388 | 0.99 | |
| 15_A | 30_M | 1.378 | 0.99 | |
| 157_Q | 161_E | 1.369 | 0.99 | |
| 93_G | 100_L | 1.362 | 0.99 | |
| 12_S | 343_A | 1.36 | 0.99 | |
| 285_G | 305_G | 1.357 | 0.99 | |
| 121_G | 125_R | 1.356 | 0.99 | |
| 173_T | 187_A | 1.349 | 0.99 | |
| 4_D | 26_L | 1.34 | 0.99 | |
| 31_T | 167_L | 1.336 | 0.99 | |
| 36_P | 168_F | 1.334 | 0.99 | |
| 186_T | 191_Y | 1.332 | 0.99 | |
| 101_A | 105_H | 1.321 | 0.99 | |
| 66_R | 69_T | 1.318 | 0.99 | |
| 98_T | 101_A | 1.311 | 0.99 | |
| 147_R | 150_L | 1.295 | 0.99 | |
| 322_T | 327_D | 1.293 | 0.99 | |
| 20_Y | 23_R | 1.291 | 0.99 | |
| 70_L | 73_E | 1.291 | 0.99 | |
| 30_M | 166_Q | 1.285 | 0.99 | |
| 170_C | 186_T | 1.284 | 0.99 | |
| 88_G | 141_T | 1.282 | 0.99 | |
| 321_D | 368_L | 1.273 | 0.99 | |
| 34_H | 40_H | 1.272 | 0.99 | |
| 290_P | 294_N | 1.265 | 0.99 | |
| 349_I | 352_D | 1.265 | 0.99 | |
| 2_K | 192_Q | 1.259 | 0.99 | |
| 17_A | 199_C | 1.257 | 0.99 | |
| 5_L | 195_K | 1.254 | 0.99 | |
| 17_A | 332_I | 1.253 | 0.99 | |
| 289_F | 293_R | 1.252 | 0.99 | |
| 156_I | 160_K | 1.251 | 0.99 | |
| 117_L | 125_R | 1.25 | 0.99 | |
| 7_I | 17_A | 1.249 | 0.99 | |
| 4_D | 29_L | 1.243 | 0.98 | |
| 35_M | 169_N | 1.243 | 0.98 | |
| 35_M | 168_F | 1.237 | 0.98 | |
| 102_N | 105_H | 1.226 | 0.98 | |
| 2_K | 194_K | 1.221 | 0.98 | |
| 330_L | 353_F | 1.203 | 0.98 | |
| 198_V | 208_L | 1.202 | 0.98 | |
| 78_N | 158_L | 1.201 | 0.98 | |
| 8_I | 196_A | 1.195 | 0.98 | |
| 19_Y | 162_A | 1.192 | 0.98 | |
| 73_E | 76_R | 1.192 | 0.98 | |
| 200_A | 207_L | 1.192 | 0.98 | |
| 198_V | 331_L | 1.186 | 0.98 | |
| 223_Y | 226_D | 1.183 | 0.98 | |
| 84_F | 144_G | 1.18 | 0.98 | |
| 175_I | 184_I | 1.175 | 0.98 | |
| 45_G | 306_A | 1.173 | 0.98 | |
| 29_L | 165_A | 1.168 | 0.97 | |
| 178_D | 181_G | 1.165 | 0.97 | |
| 8_I | 200_A | 1.162 | 0.97 | |
| 115_E | 139_F | 1.161 | 0.97 | |
| 222_W | 259_K | 1.142 | 0.97 | |
| 125_R | 139_F | 1.14 | 0.97 | |
| 31_T | 193_A | 1.139 | 0.97 | |
| 182_V | 196_A | 1.136 | 0.97 | |
| 16_A | 347_G | 1.135 | 0.97 | |
| 115_E | 125_R | 1.132 | 0.97 | |
| 170_C | 191_Y | 1.13 | 0.97 | |
| 332_I | 335_L | 1.126 | 0.97 | |
| 178_D | 192_Q | 1.118 | 0.96 | |
| 224_Q | 303_L | 1.116 | 0.96 | |
| 97_S | 101_A | 1.102 | 0.96 | |
| 348_E | 352_D | 1.1 | 0.96 | |
| 159_A | 163_G | 1.098 | 0.96 | |
| 17_A | 347_G | 1.087 | 0.96 | |
| 104_A | 138_L | 1.086 | 0.96 | |
| 3_Y | 27_N | 1.085 | 0.96 | |
| 8_I | 172_V | 1.083 | 0.96 | |
| 146_L | 151_A | 1.078 | 0.95 | |
| 196_A | 328_N | 1.076 | 0.95 | |
| 21_A | 351_A | 1.062 | 0.95 | |
| 200_A | 204_V | 1.059 | 0.95 | |
| 257_A | 303_L | 1.055 | 0.95 | |
| 177_H | 182_V | 1.053 | 0.95 | |
| 323_L | 331_L | 1.041 | 0.94 | |
| 75_S | 82_P | 1.039 | 0.94 | |
| 320_I | 346_L | 1.033 | 0.94 | |
| 176_R | 190_E | 1.031 | 0.94 | |
| 104_A | 116_K | 1.027 | 0.94 | |
| 199_C | 332_I | 1.026 | 0.94 | |
| 71_W | 343_A | 1.023 | 0.93 | |
| 58_E | 62_P | 1.017 | 0.93 | |
| 28_V | 164_C | 1.017 | 0.93 | |
| 18_G | 164_C | 1.007 | 0.93 | |
| 260_I | 292_L | 1.005 | 0.93 | |
| 69_T | 73_E | 1.002 | 0.92 | |
| 322_T | 353_F | 1.002 | 0.92 | |
| 96_D | 135_Y | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3nycA | 1 | 0.9597 | 100 | 0.225 | Contact Map | 0.722 |
| 2uzzA | 4 | 1 | 100 | 0.225 | Contact Map | 0.76 |
| 2gf3A | 2 | 0.9946 | 100 | 0.268 | Contact Map | 0.786 |
| 3axbA | 1 | 0.9624 | 100 | 0.27 | Contact Map | 0.685 |
| 1y56B | 1 | 0.957 | 100 | 0.27 | Contact Map | 0.801 |
| 2gagB | 1 | 0.9543 | 100 | 0.272 | Contact Map | 0.746 |
| 1ryiA | 4 | 0.9355 | 100 | 0.281 | Contact Map | 0.819 |
| 1pj5A | 1 | 0.9731 | 100 | 0.293 | Contact Map | 0.725 |
| 3ps9A | 1 | 0.9355 | 100 | 0.309 | Contact Map | 0.758 |
| 3pvcA | 1 | 0.9328 | 100 | 0.309 | Contact Map | 0.733 |
Sequence Conservation (Image Generated using WebLogo v3)