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OPENSEQ.org
DADA - D-amino acid dehydrogenase small subunit
UniProt: P0A6J5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11407
Length: 432 (383)
Sequences: 8656
Seq/Len: 22.60
DADA
Paralog alert: 0.68 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: DADA LHGO MTOX PUUB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
211_A 216_V 4.833 1.00
2_R 247_D 3.509 1.00
4_V 237_V 3.503 1.00
31_R 223_P 3.371 1.00
223_P 240_G 3.333 1.00
168_E 171_R 3.301 1.00
165_Q 171_R 3.012 1.00
1_M 27_T 3.01 1.00
4_V 246_A 2.872 1.00
21_Q 125_E 2.866 1.00
172_L 189_G 2.859 1.00
2_R 25_E 2.825 1.00
147_Y 188_G 2.802 1.00
114_Y 392_Q 2.801 1.00
120_K 134_Q 2.8 1.00
226_Q 238_K 2.797 1.00
4_V 29_I 2.765 1.00
20_N 214_A 2.677 1.00
25_E 217_K 2.529 1.00
171_R 174_E 2.477 1.00
15_S 250_V 2.45 1.00
29_I 244_I 2.444 1.00
24_H 399_S 2.42 1.00
228_L 238_K 2.396 1.00
27_T 219_R 2.361 1.00
3_V 24_H 2.271 1.00
3_V 19_L 2.21 1.00
20_N 216_V 2.175 1.00
238_K 243_V 2.131 1.00
8_S 35_A 2.088 1.00
396_D 401_R 2.073 1.00
4_V 244_I 2.057 1.00
121_A 125_E 2.037 1.00
228_L 236_G 2.021 1.00
279_I 346_E 2.017 1.00
396_D 404_A 2.006 1.00
376_N 390_S 1.985 1.00
250_V 398_L 1.983 1.00
248_A 374_W 1.973 1.00
163_P 194_N 1.971 1.00
224_V 237_V 1.951 1.00
165_Q 193_P 1.941 1.00
155_A 158_E 1.925 1.00
13_V 204_T 1.925 1.00
225_D 238_K 1.914 1.00
239_C 242_E 1.9 1.00
151_T 166_L 1.84 1.00
379_H 390_S 1.84 1.00
274_G 355_R 1.789 1.00
169_S 173_A 1.783 1.00
8_S 28_V 1.779 1.00
21_Q 214_A 1.778 1.00
8_S 30_D 1.769 1.00
119_L 203_F 1.766 1.00
155_A 159_D 1.76 1.00
167_L 171_R 1.758 1.00
18_Y 392_Q 1.757 1.00
251_M 257_S 1.746 1.00
374_W 398_L 1.741 1.00
18_Y 391_G 1.727 1.00
374_W 394_L 1.723 1.00
17_W 21_Q 1.722 1.00
257_S 377_T 1.714 1.00
13_V 208_A 1.714 1.00
391_G 395_S 1.709 1.00
210_M 213_Q 1.685 1.00
154_I 158_E 1.682 1.00
376_N 394_L 1.68 1.00
22_A 401_R 1.672 1.00
14_A 18_Y 1.649 1.00
27_T 244_I 1.638 1.00
17_W 210_M 1.617 1.00
131_E 202_L 1.615 1.00
227_L 249_Y 1.614 1.00
22_A 399_S 1.609 1.00
329_E 333_M 1.6 1.00
248_A 398_L 1.582 1.00
170_S 174_E 1.569 1.00
141_F 150_A 1.552 1.00
251_M 373_L 1.517 1.00
219_R 222_T 1.508 1.00
209_R 212_E 1.5 1.00
136_G 191_Q 1.49 1.00
20_N 211_A 1.485 1.00
22_A 395_S 1.476 1.00
208_A 218_F 1.469 1.00
11_V 379_H 1.468 1.00
35_A 208_A 1.46 1.00
13_V 211_A 1.459 1.00
10_V 387_A 1.454 1.00
2_R 24_H 1.449 1.00
148_E 151_T 1.433 1.00
151_T 155_A 1.427 1.00
144_E 187_T 1.407 0.99
35_A 220_F 1.402 0.99
5_I 16_A 1.398 0.99
118_C 392_Q 1.393 0.99
246_A 249_Y 1.386 0.99
13_V 28_V 1.386 0.99
4_V 27_T 1.377 0.99
236_G 243_V 1.377 0.99
251_M 261_L 1.369 0.99
332_E 336_R 1.368 0.99
360_D 414_R 1.368 0.99
29_I 224_V 1.365 0.99
11_V 376_N 1.363 0.99
210_M 214_A 1.355 0.99
15_S 376_N 1.328 0.99
366_G 412_V 1.323 0.99
136_G 193_P 1.319 0.99
226_Q 263_G 1.319 0.99
28_V 218_F 1.314 0.99
29_I 219_R 1.313 0.99
5_I 15_S 1.31 0.99
118_C 121_A 1.309 0.99
209_R 213_Q 1.306 0.99
22_A 396_D 1.301 0.99
144_E 148_E 1.299 0.99
225_D 240_G 1.297 0.99
171_R 175_V 1.292 0.99
333_M 337_D 1.275 0.99
114_Y 117_D 1.274 0.99
393_L 396_D 1.273 0.99
367_R 371_K 1.273 0.99
165_Q 191_Q 1.264 0.99
154_I 166_L 1.259 0.99
167_L 175_V 1.255 0.99
230_D 235_Y 1.251 0.99
18_Y 22_A 1.248 0.99
199_D 202_L 1.246 0.98
222_T 239_C 1.244 0.98
365_V 390_S 1.235 0.98
15_S 252_A 1.232 0.98
165_Q 175_V 1.226 0.98
32_E 37_L 1.226 0.98
227_L 237_V 1.222 0.98
230_D 245_K 1.221 0.98
147_Y 151_T 1.219 0.98
29_I 246_A 1.217 0.98
121_A 124_A 1.213 0.98
251_M 375_L 1.213 0.98
17_W 214_A 1.21 0.98
14_A 391_G 1.206 0.98
154_I 190_L 1.201 0.98
3_V 248_A 1.197 0.98
126_T 210_M 1.194 0.98
6_L 253_F 1.187 0.98
374_W 397_L 1.185 0.98
325_Q 329_E 1.184 0.98
123_R 130_Y 1.183 0.98
152_R 155_A 1.177 0.98
1_M 217_K 1.176 0.98
211_A 215_G 1.157 0.97
259_A 262_K 1.147 0.97
132_G 196_E 1.143 0.97
2_R 27_T 1.141 0.97
198_G 203_F 1.14 0.97
15_S 391_G 1.139 0.97
147_Y 166_L 1.139 0.97
27_T 217_K 1.138 0.97
222_T 244_I 1.135 0.97
36_A 204_T 1.13 0.97
249_Y 372_N 1.127 0.97
16_A 28_V 1.125 0.97
236_G 245_K 1.122 0.97
228_L 243_V 1.12 0.96
10_V 40_S 1.119 0.96
19_L 395_S 1.113 0.96
227_L 373_L 1.1 0.96
141_F 147_Y 1.097 0.96
6_L 249_Y 1.094 0.96
392_Q 396_D 1.09 0.96
119_L 387_A 1.088 0.96
227_L 234_I 1.075 0.95
166_L 190_L 1.068 0.95
115_S 389_G 1.068 0.95
208_A 212_E 1.068 0.95
5_I 26_V 1.067 0.95
229_C 370_F 1.066 0.95
26_V 216_V 1.064 0.95
18_Y 21_Q 1.063 0.95
175_V 191_Q 1.06 0.95
230_D 233_Q 1.047 0.94
16_A 26_V 1.045 0.94
248_A 367_R 1.041 0.94
32_E 38_E 1.039 0.94
253_F 257_S 1.033 0.94
16_A 216_V 1.028 0.94
376_N 379_H 1.026 0.94
367_R 372_N 1.025 0.93
253_F 260_M 1.024 0.93
138_L 189_G 1.024 0.93
198_G 384_W 1.021 0.93
138_L 191_Q 1.02 0.93
143_T 146_Q 1.019 0.93
114_Y 389_G 1.016 0.93
260_M 263_G 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3nycA10.8311000.374Contact Map0.717
2gagB10.86811000.404Contact Map0.739
3axbA10.84261000.409Contact Map0.688
1y56B10.85651000.412Contact Map0.809
1ryiA40.82641000.417Contact Map0.8
1pj5A10.86341000.424Contact Map0.748
3ps9A10.84261000.435Contact Map0.751
3pvcA10.85881000.436Contact Map0.725
2uzzA40.82181000.446Contact Map0.739
3djeA20.85651000.462Contact Map0.745
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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