| UniProt: | P37906 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11822 | ||
| Length: | 426 (395) | ||
| Sequences: | 8685 | ||
| Seq/Len: | 21.99 |
| PUUB
Paralog alert: 0.68 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: DADA LHGO MTOX PUUB |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 194_I | 199_G | 4.929 | 1.00 | |
| 28_C | 54_V | 4.107 | 1.00 | |
| 156_D | 159_A | 3.53 | 1.00 | |
| 58_A | 206_A | 3.429 | 1.00 | |
| 29_D | 228_K | 3.419 | 1.00 | |
| 206_A | 221_A | 3.166 | 1.00 | |
| 31_C | 218_V | 3.155 | 1.00 | |
| 48_E | 113_R | 2.999 | 1.00 | |
| 153_E | 159_A | 2.987 | 1.00 | |
| 261_E | 331_K | 2.975 | 1.00 | |
| 31_C | 56_L | 2.941 | 1.00 | |
| 31_C | 227_A | 2.897 | 1.00 | |
| 29_D | 52_D | 2.885 | 1.00 | |
| 102_E | 376_R | 2.858 | 1.00 | |
| 209_Q | 219_R | 2.825 | 1.00 | |
| 160_I | 172_A | 2.793 | 1.00 | |
| 134_L | 171_G | 2.722 | 1.00 | |
| 47_A | 197_N | 2.668 | 1.00 | |
| 108_R | 122_P | 2.665 | 1.00 | |
| 159_A | 162_R | 2.664 | 1.00 | |
| 52_D | 200_R | 2.604 | 1.00 | |
| 42_S | 231_I | 2.56 | 1.00 | |
| 56_L | 225_V | 2.555 | 1.00 | |
| 51_F | 383_R | 2.485 | 1.00 | |
| 211_Q | 219_R | 2.37 | 1.00 | |
| 54_V | 202_Y | 2.332 | 1.00 | |
| 109_E | 113_R | 2.282 | 1.00 | |
| 380_E | 385_D | 2.236 | 1.00 | |
| 30_V | 46_L | 2.236 | 1.00 | |
| 30_V | 51_F | 2.228 | 1.00 | |
| 47_A | 199_G | 2.201 | 1.00 | |
| 219_R | 224_Q | 2.154 | 1.00 | |
| 31_C | 225_V | 2.119 | 1.00 | |
| 153_E | 176_H | 2.102 | 1.00 | |
| 151_Q | 177_S | 2.014 | 1.00 | |
| 229_Y | 358_Y | 2.01 | 1.00 | |
| 35_G | 61_I | 2.001 | 1.00 | |
| 207_V | 218_V | 1.989 | 1.00 | |
| 157_A | 161_R | 1.972 | 1.00 | |
| 208_T | 219_R | 1.968 | 1.00 | |
| 360_M | 374_A | 1.963 | 1.00 | |
| 231_I | 382_L | 1.911 | 1.00 | |
| 380_E | 388_R | 1.909 | 1.00 | |
| 220_T | 223_G | 1.908 | 1.00 | |
| 363_Y | 374_A | 1.898 | 1.00 | |
| 27_T | 226_T | 1.867 | 1.00 | |
| 232_V | 238_L | 1.854 | 1.00 | |
| 40_L | 187_A | 1.835 | 1.00 | |
| 107_I | 186_L | 1.834 | 1.00 | |
| 48_E | 197_N | 1.827 | 1.00 | |
| 44_L | 48_E | 1.818 | 1.00 | |
| 390_D | 393_A | 1.814 | 1.00 | |
| 217_V | 224_Q | 1.813 | 1.00 | |
| 35_G | 55_V | 1.805 | 1.00 | |
| 119_D | 185_N | 1.784 | 1.00 | |
| 141_K | 145_E | 1.781 | 1.00 | |
| 238_L | 361_Q | 1.776 | 1.00 | |
| 360_M | 378_I | 1.771 | 1.00 | |
| 49_A | 385_D | 1.763 | 1.00 | |
| 45_H | 375_G | 1.755 | 1.00 | |
| 358_Y | 378_I | 1.739 | 1.00 | |
| 155_L | 159_A | 1.737 | 1.00 | |
| 35_G | 57_E | 1.736 | 1.00 | |
| 40_L | 191_A | 1.734 | 1.00 | |
| 45_H | 376_R | 1.723 | 1.00 | |
| 41_S | 45_H | 1.713 | 1.00 | |
| 358_Y | 382_L | 1.707 | 1.00 | |
| 142_E | 146_R | 1.704 | 1.00 | |
| 255_T | 340_F | 1.695 | 1.00 | |
| 49_A | 383_R | 1.688 | 1.00 | |
| 210_I | 230_V | 1.666 | 1.00 | |
| 193_A | 196_L | 1.662 | 1.00 | |
| 227_A | 230_V | 1.655 | 1.00 | |
| 28_C | 200_R | 1.646 | 1.00 | |
| 61_I | 191_A | 1.642 | 1.00 | |
| 27_T | 228_K | 1.638 | 1.00 | |
| 142_E | 145_E | 1.633 | 1.00 | |
| 192_D | 195_R | 1.609 | 1.00 | |
| 314_R | 318_P | 1.607 | 1.00 | |
| 375_G | 379_A | 1.595 | 1.00 | |
| 54_V | 225_V | 1.582 | 1.00 | |
| 44_L | 193_A | 1.577 | 1.00 | |
| 49_A | 379_A | 1.569 | 1.00 | |
| 229_Y | 382_L | 1.547 | 1.00 | |
| 138_E | 154_L | 1.54 | 1.00 | |
| 28_C | 31_C | 1.537 | 1.00 | |
| 158_N | 162_R | 1.533 | 1.00 | |
| 106_I | 376_R | 1.529 | 1.00 | |
| 123_G | 174_L | 1.503 | 1.00 | |
| 47_A | 194_I | 1.494 | 1.00 | |
| 232_V | 357_I | 1.489 | 1.00 | |
| 37_Y | 371_T | 1.482 | 1.00 | |
| 260_T | 263_L | 1.481 | 1.00 | |
| 128_A | 137_L | 1.481 | 1.00 | |
| 138_E | 142_E | 1.479 | 1.00 | |
| 38_T | 363_Y | 1.479 | 1.00 | |
| 202_Y | 205_S | 1.478 | 1.00 | |
| 40_L | 55_V | 1.465 | 1.00 | |
| 61_I | 203_E | 1.464 | 1.00 | |
| 191_A | 201_V | 1.452 | 1.00 | |
| 31_C | 54_V | 1.449 | 1.00 | |
| 29_D | 51_F | 1.446 | 1.00 | |
| 56_L | 207_V | 1.446 | 1.00 | |
| 211_Q | 217_V | 1.437 | 1.00 | |
| 317_V | 321_L | 1.436 | 1.00 | |
| 38_T | 360_M | 1.434 | 1.00 | |
| 193_A | 197_N | 1.421 | 1.00 | |
| 102_E | 105_E | 1.42 | 1.00 | |
| 217_V | 226_T | 1.414 | 1.00 | |
| 192_D | 196_L | 1.411 | 1.00 | |
| 131_D | 135_A | 1.397 | 0.99 | |
| 32_V | 43_A | 1.392 | 0.99 | |
| 135_A | 138_E | 1.381 | 0.99 | |
| 131_D | 170_T | 1.379 | 0.99 | |
| 56_L | 202_Y | 1.378 | 0.99 | |
| 42_S | 360_M | 1.373 | 0.99 | |
| 318_P | 322_K | 1.371 | 0.99 | |
| 155_L | 163_E | 1.361 | 0.99 | |
| 55_V | 201_V | 1.358 | 0.99 | |
| 350_F | 374_A | 1.358 | 0.99 | |
| 49_A | 380_E | 1.353 | 0.99 | |
| 232_V | 243_E | 1.351 | 0.99 | |
| 59_S | 63_F | 1.346 | 0.99 | |
| 153_E | 163_E | 1.345 | 0.99 | |
| 134_L | 154_L | 1.331 | 0.99 | |
| 60_R | 203_E | 1.324 | 0.99 | |
| 44_L | 197_N | 1.323 | 0.99 | |
| 123_G | 176_H | 1.319 | 0.99 | |
| 19_F | 195_R | 1.293 | 0.99 | |
| 40_L | 194_I | 1.285 | 0.99 | |
| 159_A | 163_E | 1.281 | 0.99 | |
| 32_V | 42_S | 1.266 | 0.99 | |
| 111_I | 118_C | 1.265 | 0.99 | |
| 194_I | 198_G | 1.26 | 0.99 | |
| 45_H | 49_A | 1.26 | 0.99 | |
| 41_S | 375_G | 1.259 | 0.99 | |
| 377_L | 380_E | 1.259 | 0.99 | |
| 205_S | 225_V | 1.242 | 0.98 | |
| 29_D | 54_V | 1.241 | 0.98 | |
| 106_I | 109_E | 1.238 | 0.98 | |
| 42_S | 233_A | 1.232 | 0.98 | |
| 230_V | 356_N | 1.232 | 0.98 | |
| 182_H | 185_N | 1.231 | 0.98 | |
| 213_T | 226_T | 1.229 | 0.98 | |
| 310_D | 314_R | 1.224 | 0.98 | |
| 46_L | 379_A | 1.222 | 0.98 | |
| 33_V | 234_G | 1.218 | 0.98 | |
| 56_L | 227_A | 1.216 | 0.98 | |
| 134_L | 138_E | 1.213 | 0.98 | |
| 109_E | 112_K | 1.207 | 0.98 | |
| 33_V | 230_V | 1.205 | 0.98 | |
| 261_E | 333_D | 1.204 | 0.98 | |
| 353_L | 359_Y | 1.202 | 0.98 | |
| 211_Q | 224_Q | 1.195 | 0.98 | |
| 60_R | 204_L | 1.193 | 0.98 | |
| 358_Y | 381_L | 1.188 | 0.98 | |
| 153_E | 174_L | 1.184 | 0.98 | |
| 125_L | 172_A | 1.182 | 0.98 | |
| 376_R | 380_E | 1.175 | 0.98 | |
| 130_N | 133_Q | 1.174 | 0.98 | |
| 54_V | 200_R | 1.165 | 0.97 | |
| 191_A | 195_R | 1.165 | 0.97 | |
| 62_G | 187_A | 1.164 | 0.97 | |
| 181_I | 186_L | 1.157 | 0.97 | |
| 234_G | 242_V | 1.155 | 0.97 | |
| 107_I | 371_T | 1.152 | 0.97 | |
| 208_T | 221_A | 1.143 | 0.97 | |
| 205_S | 220_T | 1.132 | 0.97 | |
| 232_V | 359_Y | 1.127 | 0.97 | |
| 43_A | 55_V | 1.127 | 0.97 | |
| 30_V | 229_Y | 1.123 | 0.97 | |
| 128_A | 134_L | 1.108 | 0.96 | |
| 350_F | 378_I | 1.107 | 0.96 | |
| 28_C | 52_D | 1.105 | 0.96 | |
| 229_Y | 352_R | 1.103 | 0.96 | |
| 234_G | 238_L | 1.102 | 0.96 | |
| 210_I | 218_V | 1.1 | 0.96 | |
| 53_V | 199_G | 1.096 | 0.96 | |
| 116_I | 189_G | 1.086 | 0.96 | |
| 213_T | 217_V | 1.085 | 0.96 | |
| 352_R | 356_N | 1.081 | 0.95 | |
| 360_M | 363_Y | 1.08 | 0.95 | |
| 28_C | 228_K | 1.079 | 0.95 | |
| 240_D | 244_P | 1.076 | 0.95 | |
| 32_V | 53_V | 1.076 | 0.95 | |
| 352_R | 358_Y | 1.072 | 0.95 | |
| 114_Y | 193_A | 1.066 | 0.95 | |
| 42_S | 375_G | 1.065 | 0.95 | |
| 120_Y | 179_G | 1.065 | 0.95 | |
| 345_S | 399_P | 1.063 | 0.95 | |
| 33_V | 207_V | 1.062 | 0.95 | |
| 141_K | 154_L | 1.054 | 0.95 | |
| 352_R | 355_T | 1.048 | 0.94 | |
| 102_E | 373_L | 1.043 | 0.94 | |
| 125_L | 174_L | 1.042 | 0.94 | |
| 295_R | 333_D | 1.03 | 0.94 | |
| 105_E | 109_E | 1.019 | 0.93 | |
| 43_A | 53_V | 1.016 | 0.93 | |
| 46_L | 51_F | 1.012 | 0.93 | |
| 68_R | 336_W | 1.004 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3nycA | 1 | 0.8404 | 100 | 0.391 | Contact Map | 0.712 |
| 3axbA | 1 | 0.8897 | 100 | 0.409 | Contact Map | 0.669 |
| 2gagB | 1 | 0.8991 | 100 | 0.413 | Contact Map | 0.729 |
| 1ryiA | 4 | 0.8615 | 100 | 0.419 | Contact Map | 0.823 |
| 1y56B | 1 | 0.8592 | 100 | 0.421 | Contact Map | 0.803 |
| 3ps9A | 1 | 0.9061 | 100 | 0.438 | Contact Map | 0.729 |
| 1pj5A | 1 | 0.892 | 100 | 0.438 | Contact Map | 0.718 |
| 3pvcA | 1 | 0.9343 | 100 | 0.439 | Contact Map | 0.706 |
| 2uzzA | 4 | 0.8286 | 100 | 0.455 | Contact Map | 0.746 |
| 3dmeA | 2 | 0.8005 | 100 | 0.466 | Contact Map | 0.707 |
Sequence Conservation (Image Generated using WebLogo v3)