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OPENSEQ.org
YBEM - Putative UPF0012 hydrolase YbeM
UniProt: P39874 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13162
Length: 262 (257)
Sequences: 7554
Seq/Len: 29.39
YBEM
Paralog alert: 0.77 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: YAFV YBEM YOBB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
2_L 235_E 3.744 1.00
216_D 220_V 3.212 1.00
136_E 141_K 3.182 1.00
214_I 234_A 3.04 1.00
190_R 193_D 2.858 1.00
4_A 233_M 2.587 1.00
85_V 109_A 2.54 1.00
95_M 109_A 2.525 1.00
4_A 33_A 2.495 1.00
13_V 16_K 2.493 1.00
225_A 230_A 2.414 1.00
26_A 74_R 2.407 1.00
20_I 229_P 2.377 1.00
184_S 224_A 2.336 1.00
21_C 42_L 2.295 1.00
145_M 156_A 2.247 1.00
226_S 230_A 2.227 1.00
143_G 159_Q 2.214 1.00
5_A 199_V 2.149 1.00
3_V 199_V 2.146 1.00
5_A 201_A 2.029 1.00
137_V 140_M 2.017 1.00
26_A 75_N 2.015 1.00
36_F 77_M 1.995 1.00
31_N 233_M 1.994 1.00
83_I 97_V 1.972 1.00
22_A 67_R 1.912 1.00
27_Q 31_N 1.91 1.00
93_W 109_A 1.897 1.00
34_S 138_E 1.89 1.00
142_V 166_I 1.853 1.00
197_Y 217_P 1.838 1.00
215_I 221_T 1.817 1.00
225_A 232_I 1.815 1.00
70_R 74_R 1.814 1.00
37_A 168_V 1.813 1.00
80_I 98_A 1.747 1.00
72_S 79_T 1.721 1.00
68_L 81_L 1.696 1.00
33_A 233_M 1.657 1.00
22_A 71_E 1.651 1.00
20_I 23_S 1.65 1.00
19_E 23_S 1.648 1.00
6_G 38_L 1.617 1.00
22_A 26_A 1.609 1.00
167_L 196_C 1.607 1.00
78_T 100_Q 1.602 1.00
25_M 36_F 1.601 1.00
96_L 170_P 1.595 1.00
141_K 165_E 1.587 1.00
69_R 99_L 1.579 1.00
165_E 242_R 1.573 1.00
184_S 188_A 1.569 1.00
145_M 169_L 1.554 1.00
95_M 107_R 1.546 1.00
185_T 188_A 1.543 1.00
37_A 201_A 1.498 1.00
6_G 36_F 1.489 1.00
15_E 19_E 1.473 1.00
24_L 27_Q 1.468 1.00
96_L 144_L 1.464 1.00
223_A 232_I 1.451 1.00
216_D 222_I 1.436 1.00
98_A 144_L 1.433 1.00
78_T 98_A 1.432 1.00
191_A 198_M 1.394 0.99
21_C 38_L 1.391 0.99
100_Q 138_E 1.387 0.99
28_A 231_L 1.372 0.99
156_A 167_L 1.37 0.99
240_R 243_Q 1.362 0.99
85_V 95_M 1.353 0.99
71_E 75_N 1.339 0.99
78_T 105_V 1.338 0.99
35_L 168_V 1.337 0.99
16_K 19_E 1.334 0.99
80_I 168_V 1.316 0.99
23_S 27_Q 1.313 0.99
154_E 157_L 1.31 0.99
199_V 214_I 1.307 0.99
185_T 192_L 1.293 0.99
70_R 73_K 1.291 0.99
166_I 199_V 1.285 0.99
80_I 96_L 1.275 0.99
187_L 200_A 1.268 0.99
91_R 126_D 1.255 0.99
25_M 79_T 1.247 0.99
61_E 65_L 1.235 0.98
80_I 144_L 1.233 0.98
78_T 137_V 1.227 0.98
34_S 100_Q 1.215 0.98
8_F 21_C 1.21 0.98
33_A 36_F 1.191 0.98
211_Q 224_A 1.185 0.98
8_F 24_L 1.174 0.98
93_W 126_D 1.168 0.97
154_E 254_R 1.161 0.97
66_G 70_R 1.155 0.97
120_Q 123_R 1.147 0.97
20_I 24_L 1.145 0.97
58_Q 62_G 1.14 0.97
99_L 104_I 1.14 0.97
76_M 100_Q 1.137 0.97
115_D 122_S 1.134 0.97
165_E 238_P 1.132 0.97
65_L 97_V 1.131 0.97
15_E 63_E 1.119 0.96
25_M 77_M 1.118 0.96
19_E 67_R 1.113 0.96
25_M 38_L 1.111 0.96
18_A 67_R 1.11 0.96
98_A 135_L 1.105 0.96
5_A 212_S 1.101 0.96
216_D 240_R 1.1 0.96
22_A 74_R 1.099 0.96
140_M 165_E 1.099 0.96
6_G 231_L 1.094 0.96
145_M 155_L 1.089 0.96
197_Y 222_I 1.072 0.95
18_A 22_A 1.063 0.95
41_A 125_V 1.063 0.95
243_Q 247_Q 1.058 0.95
191_A 215_I 1.057 0.95
158_A 162_Q 1.055 0.95
143_G 164_A 1.052 0.95
66_G 69_R 1.051 0.94
184_S 213_R 1.048 0.94
136_E 139_G 1.046 0.94
160_A 196_C 1.046 0.94
148_Y 152_F 1.045 0.94
5_A 232_I 1.04 0.94
221_T 224_A 1.037 0.94
156_A 169_L 1.036 0.94
67_R 70_R 1.032 0.94
148_Y 253_N 1.013 0.93
5_A 214_I 1.012 0.93
197_Y 240_R 1.011 0.93
187_L 198_M 1.01 0.93
134_L 164_A 1.007 0.93
108_Y 132_A 1.005 0.93
16_K 20_I 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vhhA40.98091000.056Contact Map0.785
3p8kA20.96181000.064Contact Map0.807
3hkxA10.96561000.066Contact Map0.715
2w1vA20.96951000.077Contact Map0.865
1uf5A20.98471000.085Contact Map0.796
3ivzA20.94271000.092Contact Map0.85
1emsA20.97331000.092Contact Map0.817
1f89A20.97331000.098Contact Map0.852
2dyuA20.96181000.113Contact Map0.867
2e11A40.94271000.119Contact Map0.791
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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