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OPENSEQ.org
YAFV - UPF0012 hydrolase YafV
UniProt: Q47679 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13334
Length: 256 (251)
Sequences: 7452
Seq/Len: 29.69
YAFV
Paralog alert: 0.77 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: YAFV YBEM YOBB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
5_K 231_E 3.768 1.00
130_E 135_R 3.296 1.00
211_N 215_E 3.279 1.00
209_V 230_A 3.103 1.00
180_R 183_E 2.936 1.00
7_T 229_D 2.746 1.00
7_T 35_R 2.57 1.00
92_R 106_D 2.567 1.00
17_D 20_A 2.515 1.00
25_F 44_F 2.469 1.00
30_E 72_Q 2.402 1.00
174_Q 219_T 2.326 1.00
24_H 224_Q 2.253 1.00
220_A 225_A 2.222 1.00
139_L 150_S 2.215 1.00
6_I 189_A 2.211 1.00
8_L 191_C 2.134 1.00
8_L 189_A 2.126 1.00
76_L 79_G 2.101 1.00
83_L 106_D 2.069 1.00
38_I 75_A 2.046 1.00
131_W 134_W 2.045 1.00
30_E 73_C 2.005 1.00
90_V 106_D 1.968 1.00
36_D 132_R 1.94 1.00
26_D 65_W 1.918 1.00
187_Y 212_P 1.9 1.00
68_A 72_Q 1.866 1.00
136_I 158_L 1.853 1.00
39_V 160_L 1.852 1.00
220_A 228_I 1.85 1.00
210_I 216_I 1.83 1.00
221_D 225_A 1.801 1.00
9_L 40_L 1.766 1.00
35_R 229_D 1.738 1.00
137_L 153_L 1.735 1.00
29_L 38_I 1.726 1.00
159_A 186_A 1.711 1.00
24_H 27_R 1.703 1.00
26_D 69_K 1.692 1.00
175_A 178_T 1.682 1.00
23_R 27_R 1.678 1.00
67_T 96_V 1.654 1.00
139_L 161_Y 1.629 1.00
157_D 238_R 1.624 1.00
81_V 94_L 1.619 1.00
135_R 157_D 1.607 1.00
93_F 162_V 1.597 1.00
9_L 38_I 1.575 1.00
218_A 228_I 1.565 1.00
93_F 138_P 1.554 1.00
26_D 30_E 1.55 1.00
97_E 101_T 1.528 1.00
211_N 217_I 1.522 1.00
92_R 104_F 1.506 1.00
174_Q 178_T 1.504 1.00
39_V 191_C 1.482 1.00
27_R 31_G 1.468 1.00
69_K 73_C 1.457 1.00
57_L 60_D 1.45 1.00
150_S 159_A 1.439 1.00
95_L 138_P 1.419 1.00
97_E 102_V 1.412 1.00
19_P 23_R 1.407 0.99
28_Q 31_G 1.402 0.99
148_V 151_R 1.399 0.99
59_Q 63_V 1.389 0.99
25_F 40_L 1.381 0.99
226_T 229_D 1.361 0.99
181_A 188_V 1.356 0.99
175_A 182_I 1.355 0.99
236_A 239_E 1.354 0.99
68_A 71_Q 1.346 0.99
177_L 190_G 1.338 0.99
189_A 209_V 1.331 0.99
32_I 226_T 1.325 0.99
20_A 23_R 1.31 0.99
11_Q 25_F 1.309 0.99
158_L 189_A 1.303 0.99
98_P 132_R 1.286 0.99
24_H 28_Q 1.286 0.99
37_V 160_L 1.279 0.99
63_V 94_L 1.244 0.98
11_Q 28_Q 1.23 0.98
206_D 219_T 1.228 0.98
35_R 38_I 1.226 0.98
90_V 121_K 1.218 0.98
112_R 117_H 1.187 0.98
139_L 149_W 1.182 0.98
150_S 161_Y 1.182 0.98
187_Y 217_I 1.176 0.98
64_N 68_A 1.173 0.98
83_L 92_R 1.164 0.97
29_L 69_K 1.163 0.97
36_D 98_P 1.161 0.97
89_S 121_K 1.16 0.97
26_D 72_Q 1.16 0.97
216_I 219_T 1.136 0.97
148_V 250_A 1.125 0.97
76_L 95_L 1.117 0.96
29_L 40_L 1.115 0.96
8_L 207_S 1.113 0.96
235_A 239_E 1.105 0.96
66_M 79_G 1.1 0.96
29_L 75_A 1.097 0.96
134_W 157_D 1.093 0.96
181_A 210_I 1.092 0.96
211_N 236_A 1.091 0.96
43_M 120_Y 1.083 0.96
174_Q 208_R 1.082 0.96
157_D 234_M 1.079 0.95
22_L 65_W 1.076 0.95
8_L 228_I 1.075 0.95
3_G 231_E 1.074 0.95
4_L 232_L 1.062 0.95
8_L 209_V 1.059 0.95
9_L 226_T 1.059 0.95
239_E 243_K 1.057 0.95
23_R 65_W 1.056 0.95
74_N 98_P 1.055 0.95
95_L 129_V 1.054 0.95
142_Y 146_F 1.053 0.95
19_P 61_D 1.053 0.95
105_Y 127_V 1.05 0.94
14_V 20_A 1.034 0.94
20_A 24_H 1.032 0.94
196_S 202_H 1.024 0.93
137_L 156_Y 1.024 0.93
177_L 188_V 1.023 0.93
22_L 26_D 1.019 0.93
156_Y 159_A 1.016 0.93
235_A 238_R 1.014 0.93
218_A 230_A 1.013 0.93
142_Y 249_D 1.011 0.93
154_N 186_A 1.005 0.93
94_L 104_F 1.005 0.93
5_K 229_D 1.004 0.93
64_N 67_T 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2e11A40.98831000.069Contact Map0.815
3p8kA20.98831000.076Contact Map0.831
3hkxA10.98831000.077Contact Map0.72
2w1vA20.98831000.082Contact Map0.849
2vhhA40.99611000.098Contact Map0.778
1emsA20.99221000.108Contact Map0.831
1uf5A20.99221000.114Contact Map0.794
1f89A20.99611000.116Contact Map0.844
3ivzA20.96091000.117Contact Map0.827
4hg5A40.99221000.14Contact Map0.844
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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