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ULAD - 3-keto-L-gulonate-6-phosphate decarboxylase UlaD
UniProt: P39304 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12496
Length: 216 (205)
Sequences: 1479
Seq/Len: 7.21
ULAD
Paralog alert: 0.49 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: PYRF SGBH ULAD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
199_S 202_E 3.968 1.00
23_R 53_L 3.737 1.00
51_K 82_D 3.575 1.00
14_T 17_S 3.557 1.00
6_L 190_A 2.99 1.00
197_A 203_A 2.684 1.00
90_A 94_T 2.668 1.00
202_E 206_Q 2.643 1.00
92_I 96_K 2.462 1.00
201_V 205_R 2.325 1.00
45_R 48_R 2.199 1.00
157_K 186_H 2.064 1.00
178_P 210_S 1.987 1.00
174_L 193_S 1.981 1.00
15_M 49_D 1.975 1.00
95_A 130_I 1.974 1.00
178_P 182_G 1.964 1.00
19_Y 49_D 1.901 1.00
126_R 161_D 1.875 1.00
156_I 167_T 1.826 1.00
36_T 40_V 1.805 1.00
92_I 128_A 1.799 1.00
185_I 188_F 1.794 1.00
150_E 172_L 1.79 1.00
65_I 76_C 1.688 1.00
12_N 21_T 1.635 1.00
157_K 167_T 1.615 1.00
7_Q 31_I 1.614 1.00
96_K 100_D 1.604 1.00
21_T 25_I 1.603 1.00
169_T 185_I 1.539 1.00
28_E 205_R 1.539 1.00
179_L 182_G 1.534 0.99
122_A 125_W 1.532 0.99
6_L 204_A 1.516 0.99
34_V 50_L 1.512 0.99
181_K 188_F 1.49 0.99
38_L 42_E 1.461 0.99
92_I 127_D 1.454 0.99
6_L 211_I 1.434 0.99
24_L 199_S 1.43 0.99
202_E 205_R 1.428 0.99
20_E 24_L 1.425 0.99
174_L 207_F 1.419 0.99
42_E 45_R 1.381 0.99
30_D 204_A 1.368 0.99
154_T 158_R 1.358 0.98
206_Q 209_R 1.354 0.98
40_V 65_I 1.351 0.98
24_L 200_P 1.348 0.98
179_L 183_I 1.34 0.98
126_R 160_S 1.339 0.98
41_G 75_M 1.336 0.98
49_D 52_A 1.331 0.98
156_I 160_S 1.306 0.98
17_S 20_E 1.299 0.98
15_M 42_E 1.282 0.98
73_S 84_V 1.28 0.98
10_L 50_L 1.272 0.97
15_M 46_A 1.264 0.97
18_A 38_L 1.264 0.97
84_V 102_A 1.263 0.97
9_A 191_G 1.262 0.97
93_N 96_K 1.257 0.97
32_I 57_K 1.255 0.97
89_C 121_Q 1.241 0.97
47_V 59_V 1.239 0.97
99_L 103_K 1.237 0.97
47_V 79_A 1.227 0.97
8_V 195_R 1.219 0.96
153_I 185_I 1.213 0.96
103_K 106_N 1.209 0.96
6_L 208_K 1.191 0.96
98_A 101_V 1.187 0.96
108_D 112_E 1.182 0.96
154_T 183_I 1.175 0.95
38_L 46_A 1.165 0.95
123_Q 127_D 1.158 0.95
24_L 201_V 1.153 0.95
48_R 52_A 1.152 0.95
58_I 82_D 1.111 0.93
19_Y 23_R 1.102 0.93
72_L 175_E 1.099 0.93
69_G 94_T 1.098 0.93
205_R 209_R 1.081 0.92
29_V 204_A 1.079 0.92
74_R 78_E 1.076 0.92
123_Q 159_L 1.07 0.91
22_T 32_I 1.054 0.91
13_Q 17_S 1.051 0.90
107_G 110_Q 1.049 0.90
206_Q 210_S 1.045 0.90
31_I 58_I 1.041 0.90
31_I 83_W 1.039 0.90
31_I 82_D 1.031 0.89
88_C 125_W 1.028 0.89
8_V 29_V 1.026 0.89
203_A 210_S 1.004 0.87
25_I 201_V 1.002 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qw4B20.93981000.336Contact Map0.466
3gdmA20.9121000.35Contact Map0.535
3qw3A20.93981000.356Contact Map0.507
2ffcA10.93981000.375Contact Map0.385
4mjzA20.93981000.382Contact Map0.52
3ldvA20.90741000.402Contact Map0.781
3r89A20.94441000.404Contact Map0.454
3tfxA20.92591000.413Contact Map0.727
3tr2A20.91671000.414Contact Map0.757
1eixA40.91671000.417Contact Map0.788
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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