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OPENSEQ.org
PYRF - Orotidine 5'-phosphate decarboxylase
UniProt: P08244 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10809
Length: 245 (229)
Sequences: 1382
Seq/Len: 6.03
PYRF
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: PYRF SGBH ULAD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
229_D 232_Q 3.658 1.00
100_A 126_A 3.557 1.00
34_D 64_R 3.455 1.00
25_N 28_D 3.202 1.00
17_V 220_I 3.173 1.00
62_Q 94_W 3.059 1.00
227_S 233_T 2.473 1.00
134_E 202_R 2.333 1.00
170_A 205_M 2.231 1.00
105_R 202_R 2.21 1.00
102_G 106_M 2.188 1.00
56_Q 59_R 2.184 1.00
196_S 223_P 2.128 1.00
232_Q 236_A 2.097 1.00
104_A 140_D 1.977 1.00
135_A 147_P 1.962 1.00
82_A 112_E 1.956 1.00
205_M 213_A 1.947 1.00
208_E 240_S 1.92 1.00
26_R 60_E 1.915 1.00
104_A 108_T 1.903 1.00
177_K 216_D 1.85 1.00
193_P 196_S 1.838 1.00
231_A 235_K 1.819 1.00
208_E 212_S 1.811 1.00
74_F 88_A 1.792 1.00
177_K 186_L 1.77 1.00
111_R 115_V 1.744 1.00
107_M 163_L 1.719 1.00
30_L 60_E 1.712 1.00
23_Y 32_F 1.705 1.00
47_K 51_T 1.695 1.00
159_Q 181_G 1.683 1.00
215_V 218_M 1.653 1.00
195_G 199_G 1.638 1.00
193_P 223_P 1.637 1.00
135_A 146_S 1.615 1.00
104_A 160_K 1.61 0.99
32_F 36_I 1.607 0.99
176_F 186_L 1.604 0.99
125_I 163_L 1.593 0.99
188_T 215_V 1.522 0.99
18_V 42_R 1.504 0.99
39_R 235_K 1.501 0.99
152_E 179_V 1.49 0.99
105_R 137_D 1.471 0.99
211_L 218_M 1.466 0.99
45_V 61_L 1.465 0.99
35_K 230_P 1.453 0.99
104_A 161_C 1.409 0.98
138_L 143_M 1.406 0.98
209_Q 212_S 1.403 0.98
33_V 43_L 1.394 0.98
193_P 237_I 1.394 0.98
31_A 35_K 1.383 0.98
43_L 66_F 1.381 0.98
85_V 96_V 1.369 0.98
133_M 137_D 1.365 0.98
166_V 184_F 1.363 0.98
170_A 191_I 1.362 0.98
17_V 234_L 1.36 0.98
52_L 87_A 1.342 0.98
168_C 186_L 1.316 0.97
105_R 108_T 1.306 0.97
83_H 86_A 1.297 0.97
98_V 124_L 1.291 0.97
81_A 106_M 1.28 0.96
145_L 149_D 1.26 0.96
174_V 178_Q 1.257 0.96
236_A 239_A 1.256 0.96
199_G 226_Q 1.253 0.96
236_A 240_S 1.249 0.96
49_M 57_F 1.237 0.95
195_G 236_A 1.229 0.95
97_N 127_V 1.222 0.95
101_S 154_L 1.213 0.95
49_M 53_F 1.211 0.95
235_K 239_A 1.21 0.95
41_C 234_L 1.208 0.95
81_A 110_A 1.2 0.94
209_Q 213_A 1.197 0.94
232_Q 235_K 1.187 0.94
129_V 133_M 1.187 0.94
19_V 225_T 1.182 0.94
35_K 229_D 1.179 0.94
82_A 113_A 1.179 0.94
150_Y 154_L 1.171 0.93
156_A 179_V 1.164 0.93
134_E 137_D 1.157 0.93
41_C 66_F 1.157 0.93
97_N 107_M 1.153 0.93
159_Q 180_F 1.153 0.93
17_V 241_L 1.131 0.92
17_V 238_N 1.131 0.92
97_N 125_I 1.126 0.92
28_D 31_A 1.122 0.91
108_T 112_E 1.116 0.91
146_S 149_D 1.106 0.91
110_A 113_A 1.101 0.90
198_A 202_R 1.098 0.90
51_T 74_F 1.091 0.90
198_A 204_I 1.081 0.89
26_R 53_F 1.072 0.89
168_C 176_F 1.072 0.89
123_L 185_K 1.061 0.88
70_L 93_V 1.059 0.88
136_S 139_V 1.049 0.87
176_F 180_F 1.047 0.87
126_A 163_L 1.027 0.86
95_M 123_L 1.025 0.85
20_A 221_G 1.017 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1eixA411000.32Contact Map0.808
3gdmA20.94691000.348Contact Map0.545
3tr2A20.97141000.35Contact Map0.78
3ldvA20.98781000.353Contact Map0.76
2yyuA20.95921000.369Contact Map0.843
1dbtA30.95511000.375Contact Map0.85
3qw4B20.91841000.376Contact Map0.473
3tfxA20.95921000.379Contact Map0.769
3r89A20.94691000.389Contact Map0.42
3l52A10.93471000.393Contact Map0.395
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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