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OPENSEQ.org
PRMB - 50S ribosomal protein L3 glutamine methyltransferase
UniProt: P39199 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12449
Length: 310 (281)
Sequences: 1890
Seq/Len: 6.73
PRMB
Paralog alert: 0.37 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: PRMB PRMC TRMN6
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
82_R 88_I 4.382 1.00
147_A 161_A 3.893 1.00
105_Y 174_Q 3.694 1.00
96_K 103_E 3.611 1.00
190_S 195_D 3.304 1.00
69_T 72_E 2.683 1.00
109_R 167_D 2.634 1.00
104_F 149_A 2.517 1.00
202_D 253_A 2.475 1.00
79_R 93_L 2.472 1.00
92_Y 226_E 2.467 1.00
147_A 159_V 2.466 1.00
102_H 152_Y 2.456 1.00
248_A 258_L 2.438 1.00
234_G 239_K 2.399 1.00
137_L 201_Y 2.339 1.00
95_N 105_Y 2.328 1.00
164_I 229_L 2.317 1.00
148_I 181_L 2.316 1.00
176_I 187_P 2.3 1.00
150_C 205_V 2.29 1.00
110_V 143_S 2.288 1.00
102_H 149_A 2.285 1.00
166_P 189_R 2.2 1.00
116_P 119_E 2.197 1.00
151_A 159_V 2.167 1.00
19_M 68_L 2.131 1.00
160_D 201_Y 2.112 1.00
236_D 242_R 2.102 1.00
252_L 256_G 2.095 1.00
107_D 171_V 2.076 1.00
141_T 172_A 2.064 1.00
213_A 232_A 1.982 1.00
193_F 251_Y 1.919 1.00
104_F 145_C 1.917 1.00
42_W 46_V 1.91 1.00
87_R 221_N 1.896 1.00
49_V 76_I 1.887 1.00
141_T 147_A 1.854 1.00
100_C 153_A 1.806 1.00
51_P 94_T 1.797 1.00
91_A 97_A 1.783 1.00
68_L 72_E 1.722 1.00
98_W 103_E 1.688 1.00
124_K 259_I 1.666 1.00
23_S 80_V 1.658 1.00
104_F 148_I 1.634 1.00
40_N 44_E 1.621 1.00
102_H 153_A 1.618 1.00
191_D 243_R 1.616 1.00
216_M 232_A 1.548 0.99
91_A 112_V 1.544 0.99
135_H 158_E 1.543 0.99
192_L 240_L 1.539 0.99
161_A 185_V 1.502 0.99
98_W 101_G 1.496 0.99
228_E 232_A 1.495 0.99
169_L 187_P 1.494 0.99
106_V 110_V 1.491 0.99
233_S 241_T 1.469 0.99
139_M 244_I 1.458 0.99
235_T 242_R 1.454 0.99
165_S 168_A 1.452 0.99
216_M 219_L 1.443 0.99
106_V 171_V 1.43 0.99
241_T 260_C 1.425 0.99
121_I 146_I 1.425 0.99
212_D 215_D 1.424 0.99
233_S 239_K 1.422 0.99
148_I 179_H 1.409 0.99
191_D 194_R 1.388 0.99
161_A 187_P 1.38 0.98
137_L 193_F 1.367 0.98
154_F 157_A 1.36 0.98
236_D 239_K 1.356 0.98
105_Y 178_E 1.355 0.98
120_L 259_I 1.353 0.98
206_T 260_C 1.345 0.98
20_L 23_S 1.33 0.98
51_P 79_R 1.325 0.98
117_I 146_I 1.323 0.98
241_T 262_V 1.318 0.98
124_K 203_L 1.299 0.97
100_C 122_N 1.296 0.97
192_L 243_R 1.292 0.97
52_S 79_R 1.292 0.97
138_D 147_A 1.286 0.97
100_C 149_A 1.283 0.97
88_I 108_E 1.261 0.97
63_M 66_A 1.254 0.97
109_R 171_V 1.25 0.97
121_I 149_A 1.231 0.96
148_I 176_I 1.231 0.96
58_D 62_D 1.221 0.96
107_D 167_D 1.217 0.96
46_V 57_L 1.209 0.96
201_Y 204_I 1.195 0.95
136_I 157_A 1.194 0.95
151_A 184_N 1.186 0.95
26_R 30_A 1.178 0.95
129_I 203_L 1.177 0.95
27_F 80_V 1.175 0.95
172_A 187_P 1.163 0.94
23_S 76_I 1.159 0.94
112_V 226_E 1.157 0.94
147_A 151_A 1.138 0.93
82_R 86_E 1.136 0.93
151_A 185_V 1.133 0.93
162_V 190_S 1.13 0.93
138_D 141_T 1.121 0.93
136_I 150_C 1.119 0.93
125_F 154_F 1.111 0.92
112_V 230_G 1.11 0.92
238_L 242_R 1.105 0.92
233_S 240_L 1.102 0.92
139_M 192_L 1.097 0.92
123_N 126_A 1.091 0.91
243_R 247_N 1.087 0.91
219_L 222_E 1.086 0.91
88_I 93_L 1.083 0.91
266_M 270_M 1.078 0.91
247_N 250_D 1.076 0.91
20_L 49_V 1.071 0.90
44_E 90_V 1.07 0.90
27_F 32_I 1.067 0.90
181_L 184_N 1.063 0.90
141_T 187_P 1.056 0.90
160_D 188_I 1.05 0.89
165_S 229_L 1.043 0.89
139_M 193_F 1.032 0.88
136_I 154_F 1.029 0.88
50_L 53_L 1.028 0.88
266_M 269_L 1.025 0.88
56_P 59_I 1.023 0.87
92_Y 112_V 1.023 0.87
38_T 87_R 1.012 0.87
106_V 226_E 1.006 0.86
96_K 105_Y 1.006 0.86
200_Q 253_A 1.002 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2b3tA10.87741000.423Contact Map0.789
1nv8A20.88391000.434Contact Map0.815
4dzrA10.64191000.666Contact Map0.514
2qfmA40.87421000.697Contact Map0.396
3tm4A20.91941000.701Contact Map0.381
1uwvA10.83871000.71Contact Map0.498
3evzA10.70651000.721Contact Map0.693
4mtlA20.70971000.734Contact Map0.538
1uirA20.745299.90.736Contact Map0.449
1mjfA20.722699.90.737Contact Map0.452
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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