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OPENSEQ.org
PRMC - Release factor glutamine methyltransferase
UniProt: P0ACC1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12424
Length: 277 (275)
Sequences: 2696
Seq/Len: 9.80
PRMC
Paralog alert: 0.37 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: PRMB PRMC TRMN6
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
61_R 66_E 5.354 1.00
83_F 151_R 3.915 1.00
74_V 81_P 3.588 1.00
124_A 138_A 3.323 1.00
166_S 171_A 2.645 1.00
262_R 268_E 2.54 1.00
212_S 218_V 2.479 1.00
58_L 71_L 2.414 1.00
87_A 144_D 2.396 1.00
48_T 51_Q 2.366 1.00
141_R 205_T 2.324 1.00
82_L 126_A 2.312 1.00
114_L 177_F 2.272 1.00
143_P 165_Q 2.259 1.00
124_A 136_I 2.244 1.00
80_L 129_S 2.229 1.00
153_A 163_I 2.168 1.00
178_A 229_V 2.153 1.00
80_L 126_A 2.151 1.00
70_H 202_E 2.141 1.00
236_L 250_F 2.099 1.00
228_L 232_G 2.074 1.00
85_S 148_L 2.071 1.00
25_E 36_R 2.064 1.00
94_D 97_C 2.054 1.00
88_T 120_T 2.053 1.00
210_A 215_A 2.042 1.00
73_G 83_F 2.037 1.00
118_T 149_A 2.013 1.00
127_L 181_V 1.977 1.00
224_S 234_L 1.953 1.00
189_E 208_V 1.917 1.00
221_I 250_F 1.875 1.00
78_W 130_E 1.874 1.00
128_A 136_I 1.858 1.00
35_G 38_F 1.846 1.00
137_I 177_F 1.825 1.00
28_L 55_L 1.805 1.00
76_E 81_P 1.777 1.00
6_W 47_L 1.754 1.00
125_L 158_I 1.652 1.00
69_A 75_R 1.635 1.00
168_W 216_D 1.634 1.00
137_I 164_L 1.618 1.00
42_F 45_T 1.616 1.00
80_L 130_E 1.6 1.00
169_F 227_A 1.586 1.00
118_T 124_A 1.568 1.00
10_A 59_L 1.557 1.00
167_D 219_H 1.54 1.00
98_L 235_L 1.538 1.00
204_L 208_V 1.533 1.00
30_H 72_T 1.523 1.00
78_W 100_E 1.522 1.00
101_Q 261_C 1.512 1.00
82_L 122_A 1.493 1.00
102_A 235_L 1.489 1.00
146_V 163_I 1.483 1.00
116_L 220_I 1.483 1.00
82_L 125_L 1.479 1.00
95_T 123_I 1.467 1.00
112_R 135_E 1.457 1.00
47_L 51_Q 1.455 1.00
21_R 25_E 1.45 1.00
217_I 236_L 1.444 1.00
243_G 268_E 1.434 1.00
66_E 86_P 1.42 1.00
65_G 196_Q 1.414 0.99
76_E 79_S 1.402 0.99
31_V 58_L 1.39 0.99
83_F 155_H 1.371 0.99
99_V 126_A 1.357 0.99
69_A 90_I 1.312 0.99
238_H 271_T 1.308 0.99
84_V 148_L 1.297 0.99
177_F 180_I 1.295 0.99
84_V 88_T 1.29 0.99
102_A 179_M 1.282 0.99
34_R 38_F 1.271 0.99
209_A 217_I 1.268 0.99
257_D 274_R 1.262 0.99
37_T 41_A 1.261 0.99
243_G 260_T 1.258 0.99
238_H 243_G 1.258 0.99
78_W 126_A 1.256 0.99
115_D 124_A 1.252 0.98
239_G 242_Q 1.252 0.98
195_Q 198_D 1.248 0.98
250_F 273_G 1.239 0.98
188_D 241_Q 1.233 0.98
138_A 163_I 1.228 0.98
106_L 179_M 1.225 0.98
214_M 245_A 1.225 0.98
103_L 131_R 1.225 0.98
38_F 42_F 1.218 0.98
125_L 153_A 1.209 0.98
142_M 145_A 1.207 0.98
113_I 127_L 1.194 0.98
168_W 219_H 1.193 0.98
19_S 23_D 1.191 0.98
214_M 249_A 1.188 0.98
81_P 155_H 1.179 0.98
167_D 170_S 1.175 0.97
131_R 134_C 1.174 0.97
138_A 161_I 1.169 0.97
66_E 71_L 1.169 0.97
188_D 191_D 1.165 0.97
87_A 148_L 1.163 0.97
30_H 58_L 1.136 0.97
65_G 197_G 1.124 0.96
219_H 223_Q 1.123 0.96
260_T 271_T 1.108 0.96
116_L 168_W 1.1 0.96
194_L 198_D 1.095 0.96
191_D 241_Q 1.09 0.96
102_A 181_V 1.085 0.95
13_Q 63_R 1.08 0.95
240_W 267_N 1.08 0.95
212_S 215_A 1.078 0.95
247_R 260_T 1.071 0.95
124_A 128_A 1.07 0.95
182_S 236_L 1.063 0.95
115_D 118_T 1.061 0.95
10_A 55_L 1.058 0.95
105_R 235_L 1.053 0.94
209_A 215_A 1.049 0.94
217_I 238_H 1.044 0.94
125_L 156_L 1.04 0.94
142_M 205_T 1.028 0.93
45_T 51_Q 1.027 0.93
97_C 270_V 1.024 0.93
118_T 163_I 1.023 0.93
112_R 177_F 1.02 0.93
26_I 72_T 1.018 0.93
7_L 10_A 1.015 0.93
211_D 218_V 1.002 0.92
224_S 255_Y 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2b3tA10.99281000.325Contact Map0.81
1nv8A20.95311000.34Contact Map0.85
4dzrA10.7041000.601Contact Map0.595
2qfmA40.92781000.654Contact Map0.384
3tm4A20.92421000.66Contact Map0.35
1uwvA10.89531000.662Contact Map0.473
3evzA10.76531000.67Contact Map0.67
1uirA20.79061000.695Contact Map0.458
4mtlA20.794299.90.696Contact Map0.51
1mjfA20.772699.90.705Contact Map0.445
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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