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TRMN6 - tRNA1(Val) (adenine(37)-N6)-methyltransferase
UniProt: P31825 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11538
Length: 245 (230)
Sequences: 2560
Seq/Len: 11.13

TRMN6
Paralog alert: 0.57 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: PRMB PRMC TRMN6
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
49_L 116_F 3.17 1.00
59_A 74_A 3.134 1.00
19_F 87_E 2.932 1.00
155_A 165_F 2.826 1.00
117_D 160_T 2.733 1.00
53_A 85_A 2.637 1.00
53_A 59_A 2.575 1.00
89_I 100_V 2.545 1.00
103_A 108_W 2.539 1.00
62_L 120_I 2.527 1.00
152_L 181_A 2.501 1.00
73_D 116_F 2.495 1.00
79_S 102_T 2.435 1.00
73_D 101_H 2.411 1.00
59_A 72_I 2.363 1.00
82_A 100_V 2.298 1.00
10_R 17_Q 2.226 1.00
30_G 33_G 2.141 1.00
74_A 100_V 2.063 1.00
76_E 82_A 2.02 1.00
18_F 61_M 1.996 1.00
195_A 203_H 1.984 1.00
50_D 59_A 1.953 1.00
16_K 61_M 1.919 1.00
89_I 98_I 1.9 1.00
63_A 72_I 1.891 1.00
21_A 84_Q 1.829 1.00
159_I 163_G 1.765 1.00
16_K 64_Q 1.745 1.00
53_A 76_E 1.738 1.00
23_D 80_E 1.729 1.00
12_G 17_Q 1.721 1.00
14_T 65_R 1.707 1.00
60_L 94_W 1.702 1.00
128_Q 140_A 1.696 1.00
24_R 55_S 1.678 1.00
225_G 232_E 1.627 1.00
167_V 181_A 1.619 1.00
148_H 167_V 1.575 1.00
19_F 91_Q 1.562 1.00
148_H 169_L 1.555 1.00
136_Q 140_A 1.553 1.00
118_L 166_C 1.539 1.00
104_D 150_S 1.534 1.00
181_A 209_F 1.53 1.00
144_T 149_P 1.522 1.00
12_G 15_F 1.513 1.00
71_M 99_N 1.506 1.00
37_G 194_V 1.488 1.00
106_Q 158_C 1.471 1.00
186_W 209_F 1.465 1.00
47_R 71_M 1.461 1.00
18_F 60_L 1.45 1.00
82_A 102_T 1.446 1.00
16_K 65_R 1.438 1.00
169_L 206_L 1.394 0.99
143_T 149_P 1.384 0.99
225_G 229_N 1.376 0.99
77_L 137_R 1.373 0.99
104_D 107_Q 1.363 0.99
152_L 180_L 1.35 0.99
105_I 150_S 1.341 0.99
179_E 183_S 1.318 0.99
82_A 86_Q 1.304 0.99
14_T 36_L 1.296 0.99
51_I 105_I 1.288 0.99
63_A 97_R 1.28 0.99
35_L 58_L 1.28 0.99
232_E 236_A 1.278 0.99
221_L 233_A 1.272 0.99
142_Y 147_D 1.266 0.99
151_L 165_F 1.265 0.99
154_C 157_E 1.262 0.99
83_A 86_Q 1.257 0.99
38_A 166_C 1.254 0.99
198_E 202_P 1.243 0.98
149_P 180_L 1.237 0.98
57_L 61_M 1.231 0.98
47_R 116_F 1.23 0.98
52_G 121_S 1.184 0.98
171_E 202_P 1.181 0.98
23_D 84_Q 1.18 0.98
34_I 166_C 1.169 0.97
169_L 174_G 1.162 0.97
14_T 61_M 1.16 0.97
174_G 193_D 1.16 0.97
18_F 57_L 1.15 0.97
137_R 140_A 1.15 0.97
85_A 100_V 1.146 0.97
74_A 98_I 1.132 0.97
135_P 138_E 1.123 0.97
79_S 83_A 1.119 0.96
174_G 203_H 1.118 0.96
38_A 118_L 1.115 0.96
169_L 177_F 1.106 0.96
170_P 173_I 1.095 0.96
48_C 69_S 1.085 0.96
73_D 99_N 1.083 0.96
127_Q 172_Q 1.078 0.95
166_C 207_L 1.078 0.95
190_L 208_A 1.075 0.95
190_L 218_S 1.075 0.95
59_A 98_I 1.074 0.95
21_A 87_E 1.068 0.95
48_C 66_T 1.064 0.95
167_V 177_F 1.061 0.95
141_R 147_D 1.058 0.95
41_P 164_F 1.058 0.95
52_G 105_I 1.057 0.95
26_A 84_Q 1.055 0.95
159_I 165_F 1.054 0.95
72_I 98_I 1.054 0.95
201_L 216_C 1.046 0.94
121_S 167_V 1.045 0.94
51_I 151_L 1.038 0.94
66_T 69_S 1.036 0.94
50_D 53_A 1.029 0.94
90_N 95_A 1.024 0.93
178_T 193_D 1.023 0.93
116_F 119_I 1.018 0.93
18_F 94_W 1.017 0.93
63_A 98_I 1.014 0.93
49_L 119_I 1.013 0.93
60_L 92_S 1.011 0.93
192_T 221_L 1.007 0.93
78_E 81_A 1.007 0.93
195_A 220_R 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3lpmA20.99181000.396Contact Map0.672
2ozvA20.95921000.432Contact Map0.666
2b3tA10.82861000.486Contact Map0.805
1nv8A20.80411000.499Contact Map0.79
3evzA10.86121000.576Contact Map0.713
4dzrA10.80411000.581Contact Map0.548
2qfmA40.820499.90.631Contact Map0.528
2h00A30.844999.90.651Contact Map0.581
1uwvA10.767399.90.651Contact Map0.627
2ih2A20.910299.90.655Contact Map0.641

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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