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OPENSEQ.org
PTTBC - PTS system trehalose-specific EIIBC component
UniProt: P36672 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12127
Length: 473 (462)
Sequences: 1309
Seq/Len: 2.83
PTTBC
Paralog alert: 0.77 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: PTIBC PTTBC PTV3B PTYBC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
412_L 448_I 4.383 1.00
405_G 452_I 3.86 1.00
44_R 47_E 3.786 1.00
311_F 407_G 3.479 1.00
37_L 43_A 3.143 1.00
265_C 269_L 3.091 1.00
238_A 274_A 3.039 1.00
358_G 454_I 3.03 1.00
176_C 190_G 2.973 1.00
242_L 266_S 2.76 1.00
39_Q 42_N 2.602 1.00
40_P 59_T 2.447 1.00
56_G 67_V 2.411 1.00
16_L 44_R 2.404 1.00
45_P 64_F 2.36 1.00
241_A 273_L 2.356 1.00
253_V 261_V 2.354 1.00
249_L 265_C 2.353 1.00
16_L 51_L 2.339 1.00
352_Q 392_N 2.301 1.00
412_L 441_V 2.294 1.00
78_A 81_A 2.29 1.00
177_W 191_I 2.272 1.00
408_L 452_I 2.246 1.00
332_M 339_T 2.244 1.00
257_L 261_V 2.236 1.00
14_I 79_L 2.229 1.00
24_A 38_N 2.205 1.00
412_L 416_N 2.151 1.00
45_P 49_E 2.138 1.00
46_K 49_E 2.138 1.00
250_K 258_Y 2.133 1.00
248_R 252_I 2.122 1.00
52_P 367_N 2.081 1.00
48_I 51_L 2.002 1.00
456_L 460_I 1.97 0.99
110_H 183_M 1.936 0.99
26_V 35_F 1.931 0.99
310_G 406_S 1.924 0.99
354_S 453_P 1.894 0.99
401_C 460_I 1.882 0.99
363_S 368_E 1.881 0.99
35_F 66_V 1.848 0.99
159_F 223_I 1.848 0.99
353_G 379_A 1.835 0.99
244_V 248_R 1.807 0.99
173_V 195_V 1.804 0.99
416_N 441_V 1.792 0.99
296_L 300_S 1.786 0.99
26_V 79_L 1.785 0.99
17_V 35_F 1.766 0.99
109_S 182_K 1.73 0.98
13_L 48_I 1.724 0.98
45_P 59_T 1.716 0.98
413_C 445_A 1.695 0.98
173_V 191_I 1.676 0.98
388_M 399_M 1.668 0.98
314_A 349_N 1.66 0.98
78_A 82_S 1.659 0.98
129_L 165_E 1.639 0.97
244_V 247_T 1.628 0.97
190_G 194_G 1.626 0.97
245_I 269_L 1.622 0.97
13_L 68_I 1.613 0.97
412_L 445_A 1.612 0.97
249_L 253_V 1.605 0.97
185_G 239_G 1.597 0.97
14_I 83_T 1.593 0.97
368_E 395_Y 1.591 0.97
455_V 459_F 1.576 0.97
359_I 363_S 1.57 0.97
47_E 50_Q 1.565 0.96
114_I 236_L 1.559 0.96
16_L 47_E 1.559 0.96
293_V 296_L 1.559 0.96
180_V 239_G 1.556 0.96
35_F 79_L 1.551 0.96
12_R 51_L 1.551 0.96
245_I 270_A 1.55 0.96
20_R 84_G 1.541 0.96
355_A 392_N 1.497 0.95
17_V 37_L 1.491 0.95
441_V 444_L 1.489 0.95
354_S 450_I 1.487 0.95
374_P 378_S 1.485 0.95
237_L 282_G 1.481 0.95
176_C 194_G 1.469 0.94
115_F 232_V 1.446 0.94
401_C 456_L 1.446 0.94
177_W 187_P 1.439 0.94
131_F 135_I 1.431 0.93
306_A 411_L 1.428 0.93
196_T 271_V 1.422 0.93
355_A 402_A 1.413 0.93
101_M 106_Q 1.412 0.93
357_I 376_A 1.401 0.92
315_P 403_M 1.394 0.92
49_E 394_K 1.392 0.92
166_A 195_V 1.391 0.92
346_A 442_F 1.389 0.92
284_M 288_G 1.388 0.92
118_L 178_S 1.386 0.92
258_Y 262_V 1.383 0.92
185_G 190_G 1.378 0.92
395_Y 398_P 1.363 0.91
13_L 17_V 1.358 0.91
127_L 264_V 1.348 0.90
443_A 447_A 1.344 0.90
416_N 448_I 1.344 0.90
25_T 36_V 1.343 0.90
233_I 237_L 1.343 0.90
11_D 82_S 1.334 0.90
261_V 265_C 1.333 0.90
185_G 242_L 1.331 0.90
28_H 76_Y 1.33 0.90
179_A 183_M 1.329 0.89
240_L 243_G 1.327 0.89
241_A 278_I 1.324 0.89
338_G 419_M 1.321 0.89
388_M 402_A 1.32 0.89
80_I 85_Q 1.319 0.89
282_G 286_G 1.312 0.89
177_W 188_I 1.307 0.88
183_M 240_L 1.302 0.88
306_A 310_G 1.297 0.88
306_A 410_G 1.295 0.88
356_V 387_A 1.293 0.88
350_I 353_G 1.291 0.88
183_M 243_G 1.281 0.87
376_A 380_W 1.276 0.87
270_A 274_A 1.275 0.87
360_I 373_V 1.271 0.86
240_L 244_V 1.267 0.86
30_I 383_V 1.264 0.86
77_Q 81_A 1.258 0.86
186_T 246_E 1.257 0.86
180_V 190_G 1.257 0.86
58_F 67_V 1.252 0.85
307_A 407_G 1.25 0.85
125_G 166_A 1.248 0.85
395_Y 462_Q 1.246 0.85
401_C 405_G 1.241 0.85
114_I 183_M 1.235 0.84
175_I 232_V 1.231 0.84
118_L 171_L 1.224 0.84
355_A 398_P 1.223 0.83
405_G 409_A 1.216 0.83
40_P 64_F 1.215 0.83
289_V 316_L 1.208 0.82
193_L 267_L 1.204 0.82
14_I 23_I 1.2 0.82
76_Y 80_I 1.196 0.82
348_S 352_Q 1.183 0.81
51_L 54_V 1.183 0.81
400_L 404_I 1.18 0.80
132_R 157_Y 1.176 0.80
184_G 190_G 1.166 0.79
202_L 275_H 1.161 0.79
228_Y 234_P 1.16 0.79
359_I 391_I 1.16 0.79
12_R 15_E 1.153 0.78
14_I 82_S 1.148 0.78
411_L 415_L 1.147 0.78
128_I 164_G 1.145 0.78
452_I 456_L 1.142 0.77
365_K 368_E 1.14 0.77
404_I 456_L 1.14 0.77
245_I 266_S 1.128 0.76
26_V 80_I 1.128 0.76
405_G 408_L 1.119 0.75
352_Q 355_A 1.118 0.75
110_H 114_I 1.114 0.75
412_L 444_L 1.112 0.75
15_E 44_R 1.11 0.74
107_L 110_H 1.098 0.73
384_T 387_A 1.093 0.73
449_A 453_P 1.092 0.73
359_I 398_P 1.089 0.72
94_K 97_A 1.087 0.72
11_D 15_E 1.086 0.72
28_H 72_V 1.084 0.72
120_P 323_Q 1.08 0.71
177_W 239_G 1.079 0.71
37_L 64_F 1.072 0.71
361_I 454_I 1.062 0.70
418_V 445_A 1.062 0.70
71_N 255_D 1.057 0.69
314_A 399_M 1.056 0.69
362_S 397_F 1.054 0.69
68_I 75_Y 1.053 0.69
179_A 240_L 1.051 0.68
170_Y 200_P 1.049 0.68
316_L 325_T 1.047 0.68
190_G 239_G 1.046 0.68
176_C 184_G 1.046 0.68
233_I 282_G 1.044 0.68
380_W 450_I 1.042 0.68
194_G 235_A 1.041 0.67
237_L 278_I 1.04 0.67
193_L 270_A 1.039 0.67
239_G 243_G 1.037 0.67
362_S 458_S 1.037 0.67
294_R 340_P 1.036 0.67
379_A 384_T 1.036 0.67
48_I 66_V 1.03 0.66
307_A 408_L 1.027 0.66
125_G 167_I 1.025 0.66
448_I 452_I 1.024 0.66
440_Q 444_L 1.023 0.65
387_A 392_N 1.022 0.65
285_I 288_G 1.021 0.65
59_T 64_F 1.018 0.65
45_P 48_I 1.016 0.65
354_S 380_W 1.013 0.64
352_Q 384_T 1.013 0.64
180_V 185_G 1.009 0.64
312_L 315_P 1.004 0.63
103_W 106_Q 1.003 0.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qnqA40.79281000.674Contact Map0.41
3ipjA20.19871000.819Contact Map0.852
3bp3A20.17341000.825Contact Map0.79
1ibaA10.19871000.826Contact Map0.367
2lvwA20.158622.60.98Contact Map0.483
2m5zA10.09320.30.98Contact Map0.39
3u12A20.171219.90.98Contact Map0.468
1kftA10.105718.40.981Contact Map0.666
4bxoA10.148160.981Contact Map0.479
3q9vA20.1226130.982Contact Map0.174
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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