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OPENSEQ.org
PTV3B - PTS system beta-glucoside-specific EIIBCA component
UniProt: P08722 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10115
Length: 625 (619)
Sequences: 681
Seq/Len: 1.10
PTV3B
Paralog alert: 0.49 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: PTIBC PTTBC PTV3B PTYBC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
548_V 577_I 4.325 1.00
501_G 505_K 4.197 1.00
520_V 538_S 4.087 1.00
521_A 571_N 3.63 1.00
389_S 445_G 3.259 1.00
539_D 569_K 3.25 1.00
561_S 578_S 3.168 1.00
559_F 583_A 3.066 1.00
563_H 575_R 3.018 1.00
565_N 568_D 2.96 1.00
160_G 174_A 2.824 1.00
520_V 536_I 2.785 1.00
483_M 516_V 2.681 1.00
515_E 578_S 2.661 1.00
515_E 575_R 2.646 1.00
396_I 441_C 2.612 1.00
223_S 259_T 2.608 1.00
554_K 589_F 2.604 1.00
514_G 581_I 2.547 1.00
542_V 623_I 2.533 0.99
510_L 590_D 2.532 0.99
342_G 447_V 2.418 0.99
227_C 251_C 2.405 0.99
516_V 546_I 2.4 0.99
484_T 513_V 2.399 0.99
550_I 594_P 2.392 0.99
493_V 508_A 2.365 0.99
525_A 537_E 2.346 0.99
51_M 62_V 2.346 0.99
563_H 578_S 2.317 0.99
494_A 590_D 2.233 0.98
531_L 562_A 2.232 0.98
571_N 574_D 2.227 0.98
295_G 391_A 2.211 0.98
250_L 254_V 2.195 0.98
568_D 574_D 2.19 0.98
316_N 323_D 2.186 0.98
483_M 593_T 2.184 0.98
3_E 7_K 2.137 0.98
581_I 585_R 2.135 0.98
555_L 559_F 2.092 0.97
558_K 587_A 2.09 0.97
43_L 46_T 2.061 0.97
517_R 575_R 2.061 0.97
491_I 501_G 2.058 0.97
524_I 536_I 2.052 0.97
39_Q 42_V 2.04 0.97
522_G 536_I 2.038 0.97
161_Y 175_M 1.956 0.96
494_A 592_T 1.927 0.95
337_V 363_S 1.892 0.94
591_L 594_P 1.87 0.94
164_G 224_A 1.867 0.94
521_A 572_T 1.861 0.94
483_M 594_P 1.833 0.93
505_K 605_D 1.819 0.93
527_L 566_V 1.801 0.92
523_R 569_K 1.772 0.91
160_G 178_G 1.748 0.91
583_A 587_A 1.747 0.91
555_L 558_K 1.737 0.90
47_P 351_Q 1.721 0.90
521_A 539_D 1.717 0.90
143_I 208_V 1.703 0.89
102_Y 166_R 1.69 0.89
2_T 6_R 1.686 0.89
518_S 521_A 1.68 0.88
280_W 284_A 1.673 0.88
32_L 38_A 1.673 0.88
103_V 167_F 1.654 0.87
40_A 44_K 1.643 0.87
497_T 503_L 1.635 0.86
157_I 179_G 1.634 0.86
583_A 586_E 1.63 0.86
40_A 59_F 1.628 0.86
555_L 583_A 1.595 0.85
531_L 563_H 1.595 0.85
35_E 54_E 1.592 0.84
9_V 74_V 1.591 0.84
396_I 434_G 1.591 0.84
527_L 531_L 1.574 0.83
534_I 577_I 1.567 0.83
336_Q 376_N 1.563 0.83
34_D 37_K 1.561 0.83
563_H 574_D 1.551 0.82
11_G 39_Q 1.55 0.82
595_V 620_L 1.548 0.82
21_L 30_F 1.537 0.81
385_I 453_T 1.528 0.81
481_S 509_I 1.526 0.81
111_L 162_T 1.524 0.81
330_M 435_G 1.521 0.80
520_V 544_I 1.518 0.80
372_V 383_F 1.513 0.80
544_I 597_I 1.511 0.80
108_F 217_V 1.496 0.79
436_V 440_G 1.492 0.79
582_P 586_E 1.488 0.78
527_L 562_A 1.481 0.78
40_A 54_E 1.476 0.78
581_I 591_L 1.473 0.77
118_T 150_A 1.468 0.77
124_M 128_A 1.466 0.77
516_V 579_F 1.461 0.77
358_S 362_T 1.458 0.76
579_F 584_I 1.443 0.75
531_L 561_S 1.443 0.75
267_S 271_S 1.429 0.74
242_I 246_F 1.416 0.73
234_L 250_L 1.413 0.73
575_R 578_S 1.399 0.72
12_V 32_L 1.392 0.72
582_P 585_R 1.389 0.71
480_C 572_T 1.382 0.71
122_K 149_D 1.381 0.71
94_G 99_R 1.376 0.70
555_L 594_P 1.374 0.70
559_F 589_F 1.368 0.70
174_A 178_G 1.365 0.69
107_I 221_I 1.346 0.68
352_K 379_R 1.346 0.68
235_N 243_K 1.328 0.66
599_N 603_F 1.328 0.66
559_F 587_A 1.325 0.66
19_V 33_K 1.32 0.66
338_G 443_F 1.318 0.66
51_M 303_F 1.313 0.65
392_L 445_G 1.309 0.65
479_I 520_V 1.308 0.65
527_L 577_I 1.308 0.65
178_G 220_I 1.306 0.65
558_K 583_A 1.296 0.64
531_L 534_I 1.296 0.64
180_A 256_T 1.293 0.63
162_T 172_F 1.288 0.63
4_L 46_T 1.284 0.63
157_I 175_M 1.284 0.63
522_G 538_S 1.281 0.62
448_M 452_I 1.279 0.62
510_L 585_R 1.278 0.62
518_S 572_T 1.277 0.62
487_I 507_I 1.273 0.62
21_L 74_V 1.273 0.62
164_G 174_A 1.265 0.61
170_N 231_E 1.264 0.61
11_G 46_T 1.262 0.61
518_S 536_I 1.262 0.61
446_T 548_V 1.262 0.61
341_L 360_A 1.259 0.60
513_V 579_F 1.259 0.60
488_V 592_T 1.258 0.60
614_I 618_E 1.254 0.60
510_L 591_L 1.248 0.59
379_R 455_K 1.247 0.59
486_E 510_L 1.241 0.59
548_V 579_F 1.238 0.58
513_V 581_I 1.236 0.58
15_A 79_G 1.233 0.58
7_K 46_T 1.231 0.58
338_G 446_T 1.228 0.57
298_Q 333_I 1.225 0.57
161_Y 171_P 1.224 0.57
517_R 616_A 1.223 0.57
518_S 538_S 1.223 0.57
505_K 600_S 1.216 0.56
483_M 579_F 1.214 0.56
349_D 352_K 1.212 0.56
483_M 591_L 1.211 0.56
338_G 364_L 1.21 0.56
43_L 61_V 1.21 0.56
226_L 258_V 1.21 0.56
150_A 179_G 1.209 0.56
169_G 224_A 1.204 0.55
346_C 381_Y 1.201 0.55
516_V 548_V 1.199 0.55
233_R 237_W 1.199 0.55
11_G 42_V 1.199 0.55
332_A 336_Q 1.196 0.54
35_E 59_F 1.193 0.54
107_I 167_F 1.19 0.54
488_V 493_V 1.188 0.54
111_L 155_F 1.187 0.54
294_G 390_G 1.183 0.53
434_G 437_I 1.18 0.53
347_E 352_K 1.18 0.53
168_G 174_A 1.176 0.53
154_F 184_P 1.173 0.52
514_G 582_P 1.172 0.52
123_G 298_Q 1.167 0.52
490_L 506_G 1.165 0.52
536_I 546_I 1.165 0.52
96_L 100_F 1.161 0.51
298_Q 372_V 1.16 0.51
523_R 537_E 1.157 0.51
222_F 267_S 1.157 0.51
396_I 400_A 1.156 0.51
41_E 44_K 1.155 0.51
177_I 223_S 1.151 0.50
18_I 80_L 1.148 0.50
530_T 548_V 1.146 0.50
558_K 586_E 1.145 0.50
551_D 554_K 1.142 0.49
125_L 141_Y 1.142 0.49
524_I 570_V 1.138 0.49
168_G 224_A 1.132 0.48
344_F 357_G 1.131 0.48
62_V 303_F 1.131 0.48
334_M 337_V 1.129 0.48
123_G 383_F 1.127 0.48
121_L 148_S 1.126 0.48
230_L 255_I 1.126 0.48
581_I 584_I 1.125 0.48
167_F 225_W 1.118 0.47
6_R 10_A 1.118 0.47
609_H 622_S 1.115 0.47
290_G 395_T 1.114 0.47
379_R 382_P 1.112 0.46
290_G 294_G 1.11 0.46
508_A 592_T 1.109 0.46
147_A 230_L 1.109 0.46
165_K 171_P 1.108 0.46
118_T 151_L 1.107 0.46
345_L 447_V 1.104 0.46
298_Q 383_F 1.101 0.45
96_L 99_R 1.098 0.45
25_A 367_I 1.097 0.45
516_V 621_L 1.096 0.45
479_I 521_A 1.095 0.45
115_M 307_W 1.094 0.45
18_I 499_A 1.09 0.44
20_S 31_K 1.089 0.44
584_I 593_T 1.088 0.44
389_S 392_L 1.088 0.44
524_I 538_S 1.086 0.44
393_G 442_A 1.085 0.44
497_T 502_L 1.081 0.44
30_F 61_V 1.08 0.43
385_I 389_S 1.079 0.43
53_V 62_V 1.078 0.43
73_A 76_S 1.076 0.43
520_V 542_V 1.075 0.43
529_A 566_V 1.072 0.43
339_A 386_A 1.066 0.42
397_I 438_A 1.066 0.42
514_G 567_G 1.065 0.42
515_E 563_H 1.064 0.42
479_I 620_L 1.062 0.42
278_Y 324_T 1.062 0.42
160_G 168_G 1.062 0.42
489_P 492_H 1.061 0.42
10_A 596_L 1.057 0.41
266_L 271_S 1.057 0.41
580_D 583_A 1.057 0.41
507_I 620_L 1.057 0.41
322_Y 403_K 1.055 0.41
484_T 615_S 1.051 0.41
313_C 323_D 1.048 0.40
160_G 224_A 1.048 0.40
277_G 280_W 1.046 0.40
480_C 518_S 1.046 0.40
159_L 220_I 1.041 0.40
274_I 300_F 1.037 0.39
508_A 594_P 1.031 0.39
584_I 587_A 1.028 0.39
609_H 620_L 1.026 0.38
527_L 534_I 1.026 0.38
605_D 624_I 1.025 0.38
330_M 414_T 1.025 0.38
531_L 559_F 1.024 0.38
169_G 174_A 1.02 0.38
149_D 183_H 1.017 0.38
400_A 434_G 1.016 0.38
147_A 180_A 1.015 0.38
607_L 622_S 1.015 0.38
536_I 597_I 1.014 0.37
481_S 620_L 1.013 0.37
6_R 318_T 1.011 0.37
218_I 223_S 1.011 0.37
147_A 256_T 1.008 0.37
367_I 410_P 1.007 0.37
169_G 227_C 1.006 0.37
340_A 344_F 1.005 0.37
442_A 446_T 1.002 0.36
332_A 372_V 1.002 0.36
343_V 379_R 1.001 0.36
238_L 246_F 1.001 0.36
108_F 123_G 1 0.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2gprA10.24641000.764Contact Map0.615
1f3zA10.2561000.765Contact Map0.66
3qnqA40.6161000.766Contact Map0.357
3ourB40.27681000.768Contact Map0.693
1ax3A10.25761000.77Contact Map0.518
3ipjA20.14241000.883Contact Map0.883
3bp3A20.1281000.886Contact Map0.691
1ibaA10.1441000.886Contact Map0.33
1dczA10.123298.60.956Contact Map0.193
2d5dA20.118498.40.958Contact Map0.276
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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