May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
PTIBC - PTS system arbutin-, cellobiose-, and salicin-specific EIIBC component
UniProt: P24241 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10086
Length: 485 (458)
Sequences: 1314
Seq/Len: 2.87
PTIBC
Paralog alert: 0.78 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: PTIBC PTTBC PTV3B PTYBC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
402_V 442_L 4.416 1.00
43_D 46_T 3.934 1.00
395_S 446_L 3.723 1.00
299_A 397_F 3.291 1.00
254_L 258_I 3.094 1.00
227_M 263_A 3.053 1.00
36_I 42_I 3.015 1.00
347_A 448_F 2.974 1.00
166_A 180_A 2.962 1.00
38_D 41_L 2.804 1.00
7_A 11_S 2.773 1.00
231_L 255_I 2.722 1.00
8_L 50_I 2.538 1.00
242_T 250_L 2.447 1.00
238_V 254_L 2.399 1.00
15_A 43_D 2.392 1.00
44_S 63_C 2.327 1.00
39_D 58_R 2.305 1.00
55_G 66_I 2.286 1.00
398_I 446_L 2.26 1.00
167_A 181_I 2.237 1.00
341_L 382_A 2.225 1.00
230_C 262_L 2.222 1.00
15_A 50_I 2.222 1.00
23_S 37_K 2.177 1.00
51_P 356_E 2.174 1.00
6_A 10_R 2.172 1.00
246_T 250_L 2.165 1.00
239_D 247_K 2.149 1.00
44_S 48_K 2.143 1.00
45_P 48_K 2.142 1.00
237_W 241_I 2.114 1.00
402_V 406_A 2.078 1.00
402_V 435_W 2.07 1.00
13_I 78_V 1.993 1.00
320_T 327_E 1.965 0.99
77_E 80_S 1.944 0.99
34_F 65_V 1.929 0.99
25_V 34_F 1.923 0.99
109_A 173_F 1.919 0.99
163_L 185_G 1.888 0.99
4_N 7_A 1.86 0.99
284_T 288_Y 1.853 0.99
343_G 447_S 1.849 0.99
149_I 212_V 1.848 0.99
47_L 50_I 1.844 0.99
450_L 454_L 1.837 0.99
298_G 396_G 1.829 0.99
233_Y 237_W 1.809 0.99
391_A 454_L 1.802 0.99
342_G 368_A 1.802 0.99
352_T 357_L 1.789 0.99
16_L 34_F 1.755 0.99
281_L 284_T 1.742 0.99
44_S 58_R 1.729 0.98
108_D 172_K 1.718 0.98
25_V 78_V 1.715 0.98
163_L 181_I 1.714 0.98
128_K 155_D 1.673 0.98
378_L 389_L 1.663 0.98
12_V 47_L 1.655 0.98
302_P 338_N 1.646 0.98
170_A 228_T 1.646 0.98
180_A 184_A 1.645 0.98
233_Y 236_R 1.639 0.98
435_W 438_A 1.636 0.98
402_V 439_V 1.634 0.98
406_A 435_W 1.588 0.97
46_T 49_T 1.581 0.97
238_V 242_T 1.575 0.97
175_T 228_T 1.575 0.97
34_F 78_V 1.569 0.97
11_S 50_I 1.556 0.96
77_E 81_L 1.541 0.96
403_A 439_V 1.537 0.96
348_V 352_T 1.534 0.96
167_A 177_M 1.517 0.96
15_A 46_T 1.516 0.96
357_L 385_L 1.514 0.96
12_V 67_I 1.512 0.96
449_I 453_L 1.51 0.95
10_R 14_A 1.508 0.95
166_A 184_A 1.496 0.95
391_A 450_L 1.476 0.95
234_I 259_A 1.451 0.94
250_L 254_L 1.45 0.94
387_R 455_G 1.449 0.94
226_V 271_G 1.439 0.94
295_A 397_F 1.433 0.94
113_T 225_L 1.424 0.93
48_K 384_R 1.423 0.93
346_L 365_A 1.414 0.93
186_V 260_A 1.407 0.93
344_S 382_A 1.397 0.92
247_K 251_K 1.392 0.92
114_M 221_V 1.389 0.92
156_G 185_G 1.388 0.92
303_L 393_L 1.388 0.92
130_L 134_L 1.382 0.92
344_S 392_S 1.379 0.92
234_I 258_I 1.379 0.92
24_A 35_V 1.374 0.92
175_T 180_A 1.372 0.91
176_N 235_E 1.353 0.91
16_L 36_I 1.345 0.90
10_R 81_L 1.344 0.90
363_A 367_S 1.335 0.90
437_F 441_A 1.33 0.90
175_T 231_L 1.323 0.89
126_M 253_M 1.318 0.89
385_L 388_P 1.316 0.89
229_W 232_S 1.311 0.89
117_L 168_S 1.31 0.89
273_W 277_A 1.308 0.89
294_V 400_G 1.306 0.89
406_A 442_L 1.303 0.88
345_S 377_A 1.295 0.88
170_A 180_A 1.292 0.88
29_M 373_I 1.291 0.88
278_I 304_L 1.29 0.88
349_A 362_L 1.284 0.87
13_I 22_I 1.283 0.87
335_I 436_V 1.282 0.87
173_F 229_W 1.28 0.87
229_W 233_Y 1.278 0.87
378_L 392_S 1.273 0.87
169_A 173_F 1.271 0.87
165_V 221_V 1.271 0.87
343_G 444_V 1.268 0.87
230_C 267_I 1.265 0.86
222_I 226_V 1.264 0.86
271_G 275_G 1.263 0.86
27_H 75_F 1.259 0.86
167_A 178_S 1.258 0.86
391_A 395_S 1.253 0.86
385_L 456_F 1.247 0.85
339_L 342_G 1.242 0.85
134_L 139_V 1.234 0.84
113_T 173_F 1.232 0.84
57_V 66_I 1.231 0.84
124_G 156_G 1.228 0.84
117_L 161_L 1.228 0.84
173_F 232_S 1.212 0.83
390_I 394_I 1.203 0.82
183_I 256_V 1.2 0.82
141_T 144_S 1.199 0.82
12_V 16_L 1.199 0.82
326_K 409_A 1.195 0.82
174_K 180_A 1.187 0.81
259_A 263_A 1.187 0.81
13_I 82_L 1.182 0.81
13_I 81_L 1.165 0.80
127_V 154_G 1.162 0.79
217_Y 223_P 1.16 0.79
442_L 446_L 1.152 0.78
166_A 174_K 1.152 0.78
39_D 63_C 1.152 0.78
443_A 447_S 1.145 0.78
169_A 229_W 1.143 0.78
446_L 450_L 1.141 0.78
294_V 298_G 1.138 0.77
131_A 147_L 1.133 0.77
394_I 450_L 1.126 0.76
343_G 369_I 1.124 0.76
348_V 388_P 1.123 0.76
226_V 267_I 1.12 0.76
351_K 387_R 1.119 0.76
337_A 341_L 1.106 0.74
388_P 451_T 1.103 0.74
6_A 77_E 1.102 0.74
344_S 388_P 1.101 0.74
401_A 405_M 1.093 0.73
294_V 401_A 1.093 0.73
242_T 251_K 1.092 0.73
365_A 369_I 1.088 0.73
50_I 53_V 1.086 0.72
289_L 292_L 1.086 0.72
119_P 311_R 1.078 0.72
344_S 451_T 1.075 0.71
183_I 259_A 1.073 0.71
302_P 389_L 1.067 0.71
192_F 264_I 1.063 0.70
349_A 358_R 1.063 0.70
167_A 228_T 1.062 0.70
76_Q 80_S 1.061 0.70
47_L 65_V 1.059 0.70
109_A 113_T 1.058 0.70
395_S 398_I 1.057 0.70
262_L 267_I 1.052 0.69
222_I 271_G 1.051 0.69
354_N 357_L 1.05 0.69
36_I 63_C 1.049 0.69
7_A 10_R 1.048 0.69
360_T 364_A 1.045 0.68
350_W 448_F 1.044 0.68
58_R 63_C 1.042 0.68
395_S 399_C 1.041 0.68
304_L 313_F 1.039 0.68
44_S 47_L 1.037 0.67
234_I 255_I 1.031 0.67
341_L 344_S 1.03 0.67
184_A 224_A 1.03 0.67
169_A 225_L 1.027 0.66
295_A 398_I 1.022 0.66
75_F 79_V 1.022 0.66
170_A 175_T 1.021 0.66
8_L 52_G 1.019 0.65
434_V 438_A 1.017 0.65
180_A 228_T 1.017 0.65
277_A 281_L 1.014 0.65
25_V 79_V 1.011 0.65
155_D 189_H 1.011 0.65
358_R 362_L 1.005 0.64
234_I 262_L 1.005 0.64
121_I 311_R 1.004 0.64
124_G 157_A 1.004 0.64
16_L 287_G 1.001 0.63
416_P 419_F 1 0.63
9_A 78_V 1 0.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qnqA40.79591000.686Contact Map0.418
3ipjA20.19181000.826Contact Map0.891
3bp3A20.16911000.834Contact Map0.715
1ibaA10.19381000.835Contact Map0.363
3q9vA20.117526.10.981Contact Map0.129
2hwvA10.127818.40.982Contact Map0.106
2m5zA10.0907170.982Contact Map0.421
2lvwA20.152616.90.982Contact Map0.504
3u12A20.162915.70.983Contact Map0.407
1o8bA20.148514.70.983Contact Map0.598
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0688 seconds.