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PTFB3 - Fructose-like phosphotransferase enzyme IIB component 3
UniProt: P32676 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11912
Length: 113 (103)
Sequences: 926
Seq/Len: 8.99

PTFB3
Paralog alert: 0.61 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: PTFB1 PTFB2 PTFB3
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
36_S 53_D 3.359 1.00
52_E 56_R 3.286 1.00
5_V 60_A 3.273 1.00
51_D 55_R 2.938 1.00
31_E 96_S 2.91 1.00
31_E 92_Q 2.637 1.00
6_A 37_I 2.604 1.00
24_L 35_V 2.575 1.00
45_T 48_R 2.379 1.00
30_L 92_Q 2.305 1.00
90_E 93_R 2.304 1.00
59_V 98_V 2.284 1.00
86_A 90_E 2.214 1.00
92_Q 96_S 2.186 1.00
28_C 35_V 2.184 1.00
3_Y 56_R 1.997 1.00
69_A 72_E 1.964 1.00
3_Y 34_G 1.869 1.00
25_E 29_L 1.826 1.00
36_S 47_N 1.812 1.00
21_A 25_E 1.784 1.00
27_L 30_L 1.775 1.00
27_L 31_E 1.773 1.00
49_L 54_I 1.766 1.00
39_T 47_N 1.45 1.00
96_S 100_K 1.386 0.99
71_A 81_Q 1.363 0.99
3_Y 58_D 1.356 0.99
22_E 25_E 1.317 0.99
7_V 40_Q 1.287 0.99
9_A 66_I 1.24 0.98
26_K 29_L 1.218 0.98
33_W 95_M 1.204 0.97
84_I 87_F 1.203 0.97
85_Y 89_R 1.196 0.97
50_A 53_D 1.17 0.97
60_A 77_C 1.169 0.97
9_A 40_Q 1.138 0.96
18_Y 84_I 1.116 0.96
48_R 70_G 1.11 0.95
18_Y 46_E 1.11 0.95
27_L 92_Q 1.096 0.95
43_L 46_E 1.083 0.95
21_A 47_N 1.064 0.94
27_L 91_P 1.053 0.93
5_V 49_L 1.046 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2r48A10.92921000.18Contact Map0.829
2kyrA10.94691000.328Contact Map0.679
2r4qA10.92921000.349Contact Map0.778
2m1zA10.92921000.371Contact Map0.62
4mgeA20.911599.70.609Contact Map0.564
1e2bA10.88599.70.621Contact Map0.493
2l2qA10.876199.60.652Contact Map0.361
3czcA10.814298.80.754Contact Map0.396
1tvmA10.82398.70.767Contact Map0.253
1vkrA10.885980.807Contact Map0.429

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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