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OPENSEQ.org
PTFC2 - Fructose-like permease IIC component 2
UniProt: P32672 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11908
Length: 359 (332)
Sequences: 839
Seq/Len: 2.53
PTFC2
Paralog alert: 0.60 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: HRSA PTFBC PTFC1 PTFC2 PTFLB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
229_G 327_T 4.929 1.00
92_G 109_A 3.614 1.00
14_H 79_S 3.312 1.00
116_V 145_I 3.302 1.00
233_A 241_F 3.244 1.00
81_A 85_A 3.217 1.00
281_V 330_C 3.215 1.00
73_A 109_A 3.186 1.00
190_F 196_V 3.093 1.00
25_F 90_A 3.068 1.00
221_V 320_V 2.884 1.00
69_V 106_A 2.856 1.00
234_T 249_G 2.797 1.00
186_L 280_M 2.732 1.00
190_F 280_M 2.451 1.00
289_T 293_V 2.402 1.00
64_G 91_I 2.378 1.00
271_D 274_R 2.332 1.00
235_L 253_L 2.324 1.00
67_L 94_W 2.317 1.00
241_F 332_N 2.267 1.00
285_C 326_V 2.13 1.00
202_A 205_L 2.093 1.00
228_L 324_A 2.083 1.00
237_G 332_N 2.001 0.99
315_G 318_A 1.982 0.99
21_H 86_L 1.887 0.99
296_Q 311_E 1.861 0.99
55_K 59_D 1.856 0.99
204_M 219_A 1.834 0.99
189_A 283_S 1.816 0.99
75_Y 78_Y 1.802 0.99
33_L 65_L 1.762 0.98
231_G 235_L 1.711 0.98
36_S 58_F 1.709 0.98
141_V 145_I 1.705 0.98
220_A 223_I 1.697 0.98
89_C 113_G 1.663 0.97
189_A 261_T 1.645 0.97
163_N 167_Q 1.642 0.97
77_G 113_G 1.628 0.97
289_T 315_G 1.593 0.96
312_G 315_G 1.591 0.96
233_A 332_N 1.589 0.96
66_T 94_W 1.571 0.96
230_M 331_V 1.567 0.96
160_A 164_S 1.556 0.95
231_G 253_L 1.547 0.95
238_R 246_R 1.53 0.95
293_V 315_G 1.518 0.95
243_A 246_R 1.515 0.94
221_V 286_G 1.507 0.94
117_V 142_G 1.5 0.94
223_I 259_G 1.492 0.94
281_V 322_V 1.476 0.93
186_L 190_F 1.467 0.93
216_V 219_A 1.466 0.93
278_S 330_C 1.45 0.93
108_I 112_I 1.435 0.92
295_A 315_G 1.432 0.92
149_I 153_G 1.43 0.92
220_A 224_C 1.429 0.92
261_T 283_S 1.426 0.92
87_A 143_T 1.411 0.91
247_E 250_K 1.4 0.91
237_G 240_N 1.4 0.91
17_T 78_Y 1.392 0.90
158_V 199_V 1.39 0.90
28_S 143_T 1.383 0.90
232_L 324_A 1.376 0.90
71_F 90_A 1.369 0.89
295_A 311_E 1.349 0.89
328_A 332_N 1.336 0.88
322_V 326_V 1.333 0.88
271_D 335_K 1.332 0.88
289_T 322_V 1.316 0.87
288_V 292_L 1.298 0.86
192_M 261_T 1.294 0.86
21_H 75_Y 1.29 0.85
117_V 138_I 1.285 0.85
278_S 334_L 1.284 0.85
307_L 313_K 1.284 0.85
161_L 164_S 1.282 0.85
176_S 179_M 1.267 0.84
119_Y 123_I 1.266 0.84
88_P 143_T 1.265 0.84
277_P 280_M 1.259 0.83
120_L 123_I 1.249 0.83
184_M 219_A 1.247 0.83
119_Y 122_K 1.246 0.83
58_F 62_V 1.241 0.82
232_L 328_A 1.229 0.81
120_L 138_I 1.224 0.81
80_I 111_I 1.211 0.80
285_C 322_V 1.211 0.80
281_V 285_C 1.202 0.79
225_I 286_G 1.201 0.79
118_H 122_K 1.201 0.79
12_R 16_M 1.197 0.79
220_A 259_G 1.194 0.79
224_C 259_G 1.192 0.78
169_L 203_F 1.191 0.78
159_G 163_N 1.184 0.78
311_E 315_G 1.172 0.77
324_A 328_A 1.172 0.77
117_V 120_L 1.171 0.77
189_A 226_P 1.166 0.76
104_F 108_I 1.164 0.76
138_I 142_G 1.163 0.76
258_V 305_I 1.16 0.76
31_I 140_I 1.16 0.76
133_M 137_I 1.16 0.76
182_V 288_V 1.159 0.76
77_G 89_C 1.157 0.76
15_L 107_L 1.156 0.75
188_L 223_I 1.155 0.75
73_A 77_G 1.153 0.75
80_I 115_I 1.153 0.75
329_V 333_V 1.151 0.75
276_I 280_M 1.148 0.75
120_L 142_G 1.136 0.74
92_G 146_T 1.131 0.73
188_L 259_G 1.124 0.73
148_G 152_W 1.115 0.72
142_G 146_T 1.11 0.71
218_I 291_A 1.109 0.71
289_T 292_L 1.102 0.70
189_A 279_I 1.099 0.70
201_Y 208_V 1.093 0.70
75_Y 86_L 1.09 0.69
178_V 292_L 1.089 0.69
10_N 14_H 1.089 0.69
116_V 146_T 1.087 0.69
164_S 167_Q 1.084 0.69
207_C 212_V 1.083 0.68
89_C 93_A 1.08 0.68
328_A 331_V 1.075 0.68
95_V 151_M 1.065 0.67
240_N 336_S 1.063 0.66
15_L 111_I 1.055 0.66
221_V 290_A 1.054 0.65
319_A 322_V 1.051 0.65
69_V 74_A 1.05 0.65
162_T 199_V 1.047 0.65
74_A 90_A 1.045 0.64
188_L 220_A 1.04 0.64
325_V 328_A 1.039 0.64
201_Y 216_V 1.033 0.63
112_I 116_V 1.031 0.63
318_A 322_V 1.03 0.63
164_S 168_W 1.03 0.63
230_M 261_T 1.029 0.63
314_L 318_A 1.026 0.62
17_T 21_H 1.025 0.62
172_M 176_S 1.007 0.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qnqA40.98611000.723Contact Map0.484
2kncA10.133769.30.968Contact Map0.417
2l8sA10.142123.10.976Contact Map0.59
3orgA40.671317.90.978Contact Map0.214
1u7gA10.53489.20.98Contact Map0.106
4eneA20.28977.30.981Contact Map0.233
3c02A10.59895.80.982Contact Map0.296
4gxbB10.08914.80.983Contact Map
3wdoA10.5324.70.983Contact Map0.374
2kluA10.14214.30.983Contact Map0.322
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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