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OPENSEQ.org
PTXC - Putative permease IIC component GlvC
UniProt: P31452 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11710
Length: 368 (368)
Sequences: 983
Seq/Len: 2.67
PTXC
Paralog alert: 0.77 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: PTGCB PTOCB PTW3C PTXC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
73_V 92_M 3.341 1.00
94_S 179_A 3.335 1.00
295_M 311_L 3.002 1.00
292_S 327_L 2.927 1.00
303_N 306_K 2.811 1.00
61_W 65_R 2.729 1.00
341_V 345_L 2.72 1.00
340_A 344_V 2.679 1.00
149_I 186_C 2.638 1.00
160_K 174_Y 2.606 1.00
285_I 319_M 2.299 1.00
220_T 350_S 2.202 1.00
178_I 182_V 2.145 1.00
148_G 152_A 2.101 1.00
11_A 79_L 2.094 1.00
188_W 192_L 1.982 0.99
293_L 297_F 1.969 0.99
288_A 291_I 1.967 0.99
212_G 215_G 1.95 0.99
296_Y 304_R 1.916 0.99
275_G 278_A 1.906 0.99
351_T 355_L 1.866 0.99
160_K 170_Q 1.832 0.99
21_F 180_F 1.829 0.99
222_L 235_I 1.824 0.99
310_L 314_A 1.803 0.99
13_F 233_H 1.79 0.99
308_A 312_I 1.78 0.99
181_L 185_P 1.774 0.99
249_G 254_W 1.774 0.99
296_Y 308_A 1.765 0.98
221_F 343_A 1.763 0.98
150_V 179_A 1.756 0.98
146_I 183_M 1.743 0.98
248_G 254_W 1.724 0.98
23_G 361_N 1.716 0.98
153_L 182_V 1.671 0.98
146_I 186_C 1.662 0.97
221_F 340_A 1.616 0.97
161_K 164_V 1.614 0.97
157_L 178_I 1.604 0.97
248_G 252_M 1.595 0.97
305_V 308_A 1.593 0.96
214_L 218_V 1.581 0.96
250_I 253_Y 1.565 0.96
249_G 253_Y 1.536 0.95
223_E 282_N 1.524 0.95
157_L 160_K 1.517 0.95
26_V 64_F 1.517 0.95
153_L 178_I 1.488 0.94
160_K 178_I 1.487 0.94
221_F 225_I 1.468 0.94
288_A 342_H 1.465 0.94
301_P 304_R 1.463 0.94
249_G 252_M 1.462 0.94
69_L 92_M 1.456 0.93
167_G 323_I 1.442 0.93
217_W 221_F 1.429 0.93
272_F 275_G 1.429 0.93
213_A 351_T 1.42 0.92
82_Q 154_H 1.418 0.92
254_W 362_M 1.401 0.92
5_I 8_F 1.394 0.91
153_L 174_Y 1.391 0.91
149_I 182_V 1.384 0.91
24_I 28_L 1.381 0.91
295_M 307_V 1.376 0.91
213_A 355_L 1.37 0.90
353_M 358_V 1.367 0.90
352_V 356_F 1.363 0.90
337_L 341_V 1.349 0.89
211_A 218_V 1.348 0.89
295_M 298_T 1.337 0.89
223_E 346_A 1.324 0.88
275_G 281_G 1.312 0.88
94_S 146_I 1.306 0.87
252_M 256_Q 1.298 0.87
67_M 140_I 1.289 0.86
278_A 283_S 1.287 0.86
246_V 249_G 1.287 0.86
307_V 311_L 1.28 0.86
29_A 60_G 1.276 0.86
174_Y 178_I 1.276 0.86
101_F 187_A 1.275 0.86
42_L 45_P 1.271 0.85
54_H 58_E 1.27 0.85
273_P 276_G 1.264 0.85
276_G 281_G 1.263 0.85
149_I 183_M 1.256 0.84
252_M 255_A 1.254 0.84
337_L 340_A 1.253 0.84
296_Y 311_L 1.252 0.84
309_G 327_L 1.247 0.84
185_P 189_L 1.224 0.82
79_L 148_G 1.222 0.82
225_I 343_A 1.22 0.82
261_F 264_S 1.219 0.82
14_T 77_I 1.216 0.82
182_V 186_C 1.215 0.82
365_G 368_D 1.214 0.82
221_F 344_V 1.204 0.81
157_L 170_Q 1.191 0.80
266_E 269_K 1.184 0.79
245_A 248_G 1.179 0.79
249_G 255_A 1.165 0.78
77_I 88_C 1.163 0.78
278_A 281_G 1.163 0.78
297_F 301_P 1.162 0.77
246_V 250_I 1.162 0.77
157_L 175_V 1.157 0.77
320_L 367_I 1.148 0.76
288_A 327_L 1.14 0.76
240_I 363_G 1.14 0.76
246_V 253_Y 1.137 0.75
246_V 254_W 1.134 0.75
275_G 279_L 1.131 0.75
12_M 172_T 1.13 0.75
258_L 262_S 1.123 0.74
173_S 176_V 1.123 0.74
146_I 150_V 1.121 0.74
150_V 183_M 1.116 0.73
216_V 354_Y 1.111 0.73
254_W 260_E 1.109 0.73
200_G 203_S 1.105 0.72
94_S 183_M 1.103 0.72
278_A 284_K 1.101 0.72
261_F 265_A 1.099 0.72
251_Q 254_W 1.09 0.71
352_V 355_L 1.089 0.71
92_M 96_L 1.088 0.71
291_I 295_M 1.085 0.70
98_W 190_T 1.083 0.70
277_F 281_G 1.083 0.70
157_L 174_Y 1.081 0.70
292_S 311_L 1.081 0.70
94_S 150_V 1.078 0.70
323_I 332_L 1.077 0.69
96_L 131_A 1.075 0.69
253_Y 258_L 1.075 0.69
291_I 327_L 1.069 0.69
303_N 310_L 1.067 0.68
20_P 66_N 1.067 0.68
248_G 253_Y 1.065 0.68
6_Q 9_G 1.059 0.68
259_Q 263_L 1.058 0.67
21_F 179_A 1.057 0.67
257_H 260_E 1.056 0.67
207_F 211_A 1.055 0.67
205_Q 332_L 1.055 0.67
297_F 304_R 1.052 0.67
127_L 134_K 1.05 0.67
254_W 257_H 1.044 0.66
98_W 142_G 1.041 0.66
321_V 365_G 1.036 0.65
299_A 304_R 1.036 0.65
328_E 331_F 1.035 0.65
262_S 265_A 1.029 0.64
193_G 197_V 1.024 0.64
288_A 318_A 1.022 0.64
329_F 333_F 1.02 0.63
225_I 340_A 1.019 0.63
22_A 321_V 1.013 0.63
250_I 254_W 1.01 0.62
213_A 354_Y 1.009 0.62
163_P 166_L 1.008 0.62
97_T 308_A 1.006 0.62
216_V 221_F 1.006 0.62
348_S 352_V 1.005 0.62
5_I 156_R 1.002 0.61
254_W 258_L 1 0.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qnqA40.90221000.657Contact Map0.455
2bf1A10.168560.98Contact Map0
3fmpB20.1635.10.981Contact Map
3fhtA20.16350.981Contact Map0.774
2z34C20.07884.80.981Contact Map0.066
4b19A10.07884.20.982Contact Map0.603
1ciiA10.26094.10.982Contact Map0.521
2i88A10.25543.60.983Contact Map0.506
1fukA10.14952.40.984Contact Map0.532
1tzsX10.06251.70.985Contact Map
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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