| UniProt: | P21369 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11135 | ||
| Length: | 213 (206) | ||
| Sequences: | 4017 | ||
| Seq/Len: | 19.50 |
| PNCA
Paralog alert: 0.61 [within 20: 0.03] - ratio of genomes with paralogs Cluster includes: PNCA RUTB YCAC YECD |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 135_D | 169_Y | 3.853 | 1.00 | |
| 135_D | 139_R | 3.544 | 1.00 | |
| 51_Q | 110_H | 3.391 | 1.00 | |
| 121_S | 163_D | 2.854 | 1.00 | |
| 145_E | 170_K | 2.846 | 1.00 | |
| 36_L | 174_I | 2.689 | 1.00 | |
| 148_V | 161_V | 2.612 | 1.00 | |
| 14_D | 93_G | 2.61 | 1.00 | |
| 40_C | 45_E | 2.487 | 1.00 | |
| 33_A | 149_M | 2.437 | 1.00 | |
| 145_E | 172_N | 2.384 | 1.00 | |
| 11_L | 33_A | 2.375 | 1.00 | |
| 195_M | 200_A | 2.335 | 1.00 | |
| 174_I | 208_W | 2.197 | 1.00 | |
| 135_D | 167_L | 2.115 | 1.00 | |
| 5_A | 143_I | 2.112 | 1.00 | |
| 4_R | 145_E | 2.105 | 1.00 | |
| 122_A | 160_T | 2.095 | 1.00 | |
| 48_I | 137_W | 2.057 | 1.00 | |
| 133_S | 137_W | 2.054 | 1.00 | |
| 175_T | 202_L | 2.051 | 1.00 | |
| 158_K | 162_L | 1.987 | 1.00 | |
| 109_F | 137_W | 1.958 | 1.00 | |
| 41_Q | 106_A | 1.952 | 1.00 | |
| 8_L | 37_I | 1.931 | 1.00 | |
| 13_N | 92_E | 1.916 | 1.00 | |
| 39_W | 43_R | 1.916 | 1.00 | |
| 32_V | 35_R | 1.889 | 1.00 | |
| 3_P | 144_D | 1.833 | 1.00 | |
| 175_T | 204_T | 1.766 | 1.00 | |
| 35_R | 206_A | 1.746 | 1.00 | |
| 185_P | 189_A | 1.745 | 1.00 | |
| 153_T | 188_S | 1.733 | 1.00 | |
| 92_E | 95_Q | 1.73 | 1.00 | |
| 204_T | 207_D | 1.721 | 1.00 | |
| 146_L | 164_A | 1.675 | 1.00 | |
| 176_D | 205_L | 1.664 | 1.00 | |
| 164_A | 171_V | 1.648 | 1.00 | |
| 148_V | 160_T | 1.633 | 1.00 | |
| 40_C | 147_I | 1.629 | 1.00 | |
| 32_V | 177_G | 1.596 | 1.00 | |
| 63_S | 85_D | 1.582 | 1.00 | |
| 175_T | 192_F | 1.552 | 1.00 | |
| 147_I | 174_I | 1.544 | 1.00 | |
| 13_N | 98_P | 1.536 | 1.00 | |
| 25_E | 28_S | 1.53 | 1.00 | |
| 32_V | 205_L | 1.511 | 1.00 | |
| 16_C | 97_H | 1.503 | 1.00 | |
| 8_L | 33_A | 1.502 | 1.00 | |
| 158_K | 194_E | 1.499 | 1.00 | |
| 53_W | 94_A | 1.499 | 1.00 | |
| 153_T | 178_C | 1.489 | 1.00 | |
| 7_L | 148_V | 1.424 | 1.00 | |
| 4_R | 147_I | 1.422 | 1.00 | |
| 154_D | 180_G | 1.417 | 1.00 | |
| 180_G | 188_S | 1.413 | 1.00 | |
| 139_R | 169_Y | 1.401 | 0.99 | |
| 8_L | 11_L | 1.399 | 0.99 | |
| 153_T | 192_F | 1.398 | 0.99 | |
| 107_A | 137_W | 1.392 | 0.99 | |
| 177_G | 205_L | 1.39 | 0.99 | |
| 50_S | 122_A | 1.356 | 0.99 | |
| 46_A | 141_H | 1.351 | 0.99 | |
| 158_K | 191_A | 1.335 | 0.99 | |
| 29_T | 33_A | 1.331 | 0.99 | |
| 178_C | 188_S | 1.3 | 0.99 | |
| 157_V | 173_V | 1.295 | 0.99 | |
| 10_D | 111_K | 1.294 | 0.99 | |
| 38_D | 42_S | 1.294 | 0.99 | |
| 161_V | 173_V | 1.287 | 0.99 | |
| 189_A | 193_M | 1.281 | 0.99 | |
| 9_V | 148_V | 1.28 | 0.99 | |
| 186_Q | 189_A | 1.278 | 0.99 | |
| 8_L | 149_M | 1.261 | 0.99 | |
| 34_N | 99_L | 1.254 | 0.99 | |
| 6_L | 40_C | 1.251 | 0.99 | |
| 32_V | 176_D | 1.251 | 0.99 | |
| 34_N | 38_D | 1.21 | 0.98 | |
| 31_D | 99_L | 1.174 | 0.98 | |
| 144_D | 170_K | 1.157 | 0.97 | |
| 35_R | 38_D | 1.154 | 0.97 | |
| 7_L | 134_L | 1.137 | 0.97 | |
| 136_D | 140_D | 1.136 | 0.97 | |
| 182_N | 186_Q | 1.131 | 0.97 | |
| 137_W | 141_H | 1.13 | 0.97 | |
| 119_S | 168_G | 1.124 | 0.97 | |
| 153_T | 180_G | 1.119 | 0.96 | |
| 133_S | 136_D | 1.119 | 0.96 | |
| 172_N | 203_Y | 1.103 | 0.96 | |
| 51_Q | 96_L | 1.102 | 0.96 | |
| 5_A | 48_I | 1.1 | 0.96 | |
| 13_N | 95_Q | 1.096 | 0.96 | |
| 9_V | 156_C | 1.094 | 0.96 | |
| 159_F | 162_L | 1.083 | 0.96 | |
| 161_V | 195_M | 1.08 | 0.95 | |
| 35_R | 39_W | 1.08 | 0.95 | |
| 89_Q | 110_H | 1.078 | 0.95 | |
| 191_A | 195_M | 1.077 | 0.95 | |
| 37_I | 49_A | 1.067 | 0.95 | |
| 49_A | 102_Q | 1.063 | 0.95 | |
| 174_I | 177_G | 1.06 | 0.95 | |
| 34_N | 100_L | 1.046 | 0.94 | |
| 53_W | 110_H | 1.035 | 0.94 | |
| 96_L | 108_V | 1.009 | 0.93 | |
| 95_Q | 101_H | 1.008 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2wt9A | 2 | 0.9577 | 100 | 0.18 | Contact Map | 0.83 |
| 3v8eA | 7 | 0.939 | 100 | 0.196 | Contact Map | 0.813 |
| 3hb7A | 8 | 0.8404 | 100 | 0.198 | Contact Map | 0.888 |
| 1im5A | 1 | 0.8404 | 100 | 0.202 | Contact Map | 0.81 |
| 1nbaA | 4 | 0.8873 | 100 | 0.214 | Contact Map | 0.884 |
| 3r2jA | 4 | 0.8967 | 100 | 0.214 | Contact Map | 0.788 |
| 3irvA | 1 | 0.8732 | 100 | 0.217 | Contact Map | 0.834 |
| 3kl2A | 12 | 0.8967 | 100 | 0.223 | Contact Map | 0.855 |
| 3hu5A | 2 | 0.8685 | 100 | 0.224 | Contact Map | 0.806 |
| 3ot4A | 8 | 0.8592 | 100 | 0.229 | Contact Map | 0.866 |
Sequence Conservation (Image Generated using WebLogo v3)