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OPENSEQ.org
UDP - Uridine phosphorylase
UniProt: P12758 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11045
Length: 253 (247)
Sequences: 1564
Seq/Len: 6.33
UDP
Paralog alert: 0.60 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: DEOD MTNN UDP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
206_C 213_A 4.477 1.00
95_T 219_V 4.079 1.00
88_T 212_R 3.689 1.00
133_D 212_R 3.119 1.00
199_S 215_M 2.797 1.00
112_A 131_V 2.745 1.00
82_A 211_L 2.61 1.00
87_R 211_L 2.494 1.00
110_T 156_T 2.445 1.00
20_T 87_R 2.443 1.00
40_K 56_E 2.374 1.00
32_E 36_A 2.32 1.00
136_C 214_G 2.298 1.00
24_V 67_T 2.203 1.00
24_V 89_F 2.174 1.00
12_T 15_D 2.172 1.00
58_D 247_E 2.136 1.00
43_K 46_S 2.135 1.00
15_D 42_V 2.127 1.00
108_L 194_N 2.112 1.00
141_V 145_K 2.071 1.00
44_L 65_C 2.058 1.00
71_G 158_S 2.045 1.00
138_T 142_E 2.03 1.00
71_G 201_T 2.017 1.00
21_L 88_T 2.013 1.00
138_T 145_K 1.783 1.00
22_A 86_I 1.735 1.00
89_F 211_L 1.724 1.00
140_L 214_G 1.722 1.00
109_V 151_T 1.712 1.00
103_N 106_D 1.685 1.00
54_R 63_I 1.681 1.00
108_L 219_V 1.669 1.00
26_G 30_R 1.639 1.00
102_I 152_H 1.577 0.99
230_N 233_T 1.567 0.99
50_F 66_S 1.564 0.99
33_K 239_S 1.559 0.99
21_L 60_K 1.535 0.99
113_S 199_S 1.52 0.99
111_T 153_V 1.508 0.99
42_V 61_P 1.486 0.99
239_S 242_V 1.462 0.99
142_E 145_K 1.456 0.99
56_E 61_P 1.453 0.99
157_A 192_V 1.432 0.99
78_V 205_M 1.422 0.99
95_T 194_N 1.414 0.99
239_S 243_K 1.402 0.98
158_S 199_S 1.384 0.98
240_H 243_K 1.374 0.98
146_S 251_R 1.371 0.98
50_F 69_I 1.365 0.98
85_G 211_L 1.363 0.98
21_L 249_A 1.353 0.98
142_E 146_S 1.344 0.98
112_A 155_V 1.343 0.98
114_V 131_V 1.341 0.98
109_V 137_T 1.337 0.98
141_V 153_V 1.332 0.98
134_F 141_V 1.332 0.98
106_D 152_H 1.327 0.98
185_E 189_A 1.308 0.97
109_V 141_V 1.303 0.97
74_T 78_V 1.295 0.97
138_T 141_V 1.289 0.97
79_E 209_Q 1.277 0.97
152_H 193_M 1.253 0.96
52_T 65_C 1.243 0.96
75_S 201_T 1.239 0.96
232_E 236_Q 1.235 0.96
75_S 205_M 1.234 0.96
156_T 194_N 1.231 0.96
105_G 237_T 1.224 0.96
135_E 212_R 1.219 0.95
222_N 225_Q 1.218 0.95
31_V 53_W 1.207 0.95
147_I 243_K 1.2 0.95
19_A 54_R 1.198 0.95
186_E 189_A 1.195 0.95
35_A 53_W 1.182 0.94
99_Q 193_M 1.178 0.94
143_A 248_A 1.175 0.94
39_D 56_E 1.167 0.94
132_A 203_L 1.165 0.94
108_L 193_M 1.162 0.94
158_S 215_M 1.16 0.94
182_G 185_E 1.145 0.93
13_K 85_G 1.144 0.93
101_H 152_H 1.128 0.92
75_S 79_E 1.095 0.91
98_I 223_R 1.094 0.91
154_G 193_M 1.09 0.90
46_S 51_T 1.086 0.90
156_T 217_A 1.084 0.90
165_G 208_S 1.082 0.90
107_V 244_I 1.076 0.90
74_T 201_T 1.072 0.89
34_I 64_V 1.07 0.89
139_A 248_A 1.069 0.89
32_E 46_S 1.066 0.89
20_T 60_K 1.049 0.88
119_A 205_M 1.048 0.88
99_Q 102_I 1.036 0.87
97_A 222_N 1.033 0.87
139_A 143_A 1.032 0.87
19_A 61_P 1.027 0.87
5_D 12_T 1.027 0.87
19_A 63_I 1.024 0.86
38_M 55_A 1.024 0.86
76_I 80_E 1.022 0.86
134_F 138_T 1.019 0.86
196_E 199_S 1.007 0.85
194_N 219_V 1.006 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bjeA20.98421000.179Contact Map0.734
3phcA60.94471000.23Contact Map0.803
3eufA40.99211000.25Contact Map0.635
3mb8A20.94071000.257Contact Map0.721
2b94A10.94071000.265Contact Map0.701
4m3nA30.92091000.269Contact Map0.848
4m7wA30.93281000.275Contact Map0.866
3qpbA180.97631000.276Contact Map0.786
3ddoA611000.282Contact Map0.831
3p0fA10.98811000.285Contact Map0.638
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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