| UniProt: | P11447 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11223 | ||
| Length: | 457 (455) | ||
| Sequences: | 5272 | ||
| Seq/Len: | 11.59 |
| ARLY
Paralog alert: 0.85 [within 20: 0.05] - ratio of genomes with paralogs Cluster includes: ARLY ASPA FUMC PUR8 |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 38_V | 63_N | 3.344 | 1.00 | |
| 45_V | 55_Q | 3.309 | 1.00 | |
| 302_A | 331_A | 3.278 | 1.00 | |
| 355_R | 358_E | 3.274 | 1.00 | |
| 126_S | 187_L | 3.118 | 1.00 | |
| 394_E | 398_Q | 3.104 | 1.00 | |
| 42_K | 59_E | 3.035 | 1.00 | |
| 246_M | 299_V | 2.848 | 1.00 | |
| 165_F | 351_V | 2.783 | 1.00 | |
| 417_I | 420_D | 2.745 | 1.00 | |
| 133_R | 180_E | 2.704 | 1.00 | |
| 148_D | 353_R | 2.668 | 1.00 | |
| 129_L | 180_E | 2.658 | 1.00 | |
| 136_Q | 177_A | 2.648 | 1.00 | |
| 189_R | 237_E | 2.634 | 1.00 | |
| 144_Q | 453_Q | 2.61 | 1.00 | |
| 138_A | 347_D | 2.598 | 1.00 | |
| 133_R | 184_Q | 2.572 | 1.00 | |
| 295_K | 338_C | 2.543 | 1.00 | |
| 357_Q | 361_Q | 2.533 | 1.00 | |
| 268_E | 350_Q | 2.473 | 1.00 | |
| 42_K | 215_W | 2.465 | 1.00 | |
| 28_R | 333_D | 2.461 | 1.00 | |
| 91_K | 95_K | 2.427 | 1.00 | |
| 32_Q | 123_D | 2.407 | 1.00 | |
| 125_V | 238_L | 2.381 | 1.00 | |
| 141_E | 145_N | 2.348 | 1.00 | |
| 243_A | 303_L | 2.339 | 1.00 | |
| 142_T | 145_N | 2.31 | 1.00 | |
| 129_L | 184_Q | 2.302 | 1.00 | |
| 444_Q | 447_Q | 2.279 | 1.00 | |
| 138_A | 343_A | 2.258 | 1.00 | |
| 141_E | 347_D | 2.223 | 1.00 | |
| 138_A | 346_L | 2.22 | 1.00 | |
| 122_K | 191_D | 2.205 | 1.00 | |
| 45_V | 52_A | 2.134 | 1.00 | |
| 46_T | 211_Q | 2.121 | 1.00 | |
| 180_E | 184_Q | 2.111 | 1.00 | |
| 136_Q | 180_E | 2.067 | 1.00 | |
| 131_A | 340_H | 2.064 | 1.00 | |
| 268_E | 352_K | 2.056 | 1.00 | |
| 191_D | 219_A | 2.038 | 1.00 | |
| 247_V | 300_Q | 2.011 | 1.00 | |
| 51_T | 54_E | 2.002 | 1.00 | |
| 185_D | 188_K | 1.948 | 1.00 | |
| 355_R | 359_A | 1.947 | 1.00 | |
| 147_Q | 446_A | 1.931 | 1.00 | |
| 134_Q | 343_A | 1.912 | 1.00 | |
| 400_K | 408_S | 1.896 | 1.00 | |
| 140_V | 177_A | 1.86 | 1.00 | |
| 56_A | 60_E | 1.844 | 1.00 | |
| 52_A | 56_A | 1.837 | 1.00 | |
| 249_L | 292_I | 1.834 | 1.00 | |
| 343_A | 347_D | 1.825 | 1.00 | |
| 353_R | 357_Q | 1.82 | 1.00 | |
| 379_V | 387_I | 1.808 | 1.00 | |
| 185_D | 189_R | 1.801 | 1.00 | |
| 394_E | 409_E | 1.788 | 1.00 | |
| 253_A | 292_I | 1.779 | 1.00 | |
| 131_A | 336_L | 1.766 | 1.00 | |
| 222_T | 228_S | 1.764 | 1.00 | |
| 420_D | 423_P | 1.748 | 1.00 | |
| 3_L | 94_D | 1.738 | 1.00 | |
| 387_I | 415_Q | 1.715 | 1.00 | |
| 357_Q | 428_Q | 1.715 | 1.00 | |
| 193_S | 213_A | 1.712 | 1.00 | |
| 146_N | 149_A | 1.681 | 1.00 | |
| 188_K | 219_A | 1.653 | 1.00 | |
| 38_V | 59_E | 1.642 | 1.00 | |
| 387_I | 390_E | 1.634 | 1.00 | |
| 403_E | 422_Y | 1.633 | 1.00 | |
| 298_R | 327_G | 1.624 | 1.00 | |
| 54_E | 102_K | 1.617 | 1.00 | |
| 64_V | 95_K | 1.611 | 1.00 | |
| 178_R | 227_D | 1.61 | 1.00 | |
| 243_A | 307_M | 1.61 | 1.00 | |
| 179_D | 248_H | 1.601 | 1.00 | |
| 270_S | 348_G | 1.591 | 1.00 | |
| 238_L | 332_L | 1.584 | 1.00 | |
| 55_Q | 59_E | 1.579 | 1.00 | |
| 210_E | 214_G | 1.579 | 1.00 | |
| 140_V | 144_Q | 1.577 | 1.00 | |
| 197_C | 228_S | 1.569 | 1.00 | |
| 178_R | 233_D | 1.56 | 1.00 | |
| 211_Q | 215_W | 1.543 | 1.00 | |
| 354_P | 358_E | 1.534 | 1.00 | |
| 132_N | 245_G | 1.532 | 1.00 | |
| 289_L | 345_V | 1.526 | 1.00 | |
| 358_E | 362_Q | 1.525 | 1.00 | |
| 35_V | 123_D | 1.513 | 1.00 | |
| 182_R | 237_E | 1.506 | 1.00 | |
| 136_Q | 176_L | 1.506 | 1.00 | |
| 13_D | 16_F | 1.496 | 1.00 | |
| 124_T | 336_L | 1.488 | 1.00 | |
| 306_M | 328_L | 1.485 | 1.00 | |
| 253_A | 342_A | 1.475 | 1.00 | |
| 91_K | 94_D | 1.466 | 1.00 | |
| 142_T | 146_N | 1.462 | 1.00 | |
| 426_S | 429_S | 1.457 | 1.00 | |
| 400_K | 405_L | 1.454 | 1.00 | |
| 352_K | 355_R | 1.442 | 1.00 | |
| 63_N | 67_E | 1.441 | 1.00 | |
| 71_A | 74_Q | 1.428 | 1.00 | |
| 128_L | 335_W | 1.424 | 1.00 | |
| 236_L | 310_L | 1.422 | 1.00 | |
| 93_I | 100_G | 1.421 | 1.00 | |
| 133_R | 137_S | 1.417 | 1.00 | |
| 181_S | 188_K | 1.4 | 0.99 | |
| 211_Q | 214_G | 1.399 | 0.99 | |
| 213_A | 219_A | 1.387 | 0.99 | |
| 394_E | 405_L | 1.377 | 0.99 | |
| 292_I | 342_A | 1.372 | 0.99 | |
| 301_G | 305_G | 1.368 | 0.99 | |
| 319_K | 322_Q | 1.367 | 0.99 | |
| 144_Q | 147_Q | 1.359 | 0.99 | |
| 38_V | 42_K | 1.358 | 0.99 | |
| 292_I | 338_C | 1.356 | 0.99 | |
| 136_Q | 173_V | 1.354 | 0.99 | |
| 41_S | 50_L | 1.353 | 0.99 | |
| 373_Y | 420_D | 1.346 | 0.99 | |
| 240_S | 244_I | 1.341 | 0.99 | |
| 252_F | 342_A | 1.337 | 0.99 | |
| 183_L | 245_G | 1.335 | 0.99 | |
| 169_C | 172_Y | 1.313 | 0.99 | |
| 300_Q | 308_M | 1.312 | 0.99 | |
| 377_K | 420_D | 1.306 | 0.99 | |
| 298_R | 330_D | 1.302 | 0.99 | |
| 418_D | 422_Y | 1.298 | 0.99 | |
| 57_Q | 60_E | 1.297 | 0.99 | |
| 186_A | 241_A | 1.286 | 0.99 | |
| 236_L | 244_I | 1.281 | 0.99 | |
| 31_E | 70_R | 1.277 | 0.99 | |
| 173_V | 452_A | 1.277 | 0.99 | |
| 134_Q | 340_H | 1.273 | 0.99 | |
| 134_Q | 347_D | 1.272 | 0.99 | |
| 143_A | 173_V | 1.271 | 0.99 | |
| 33_D | 112_Q | 1.27 | 0.99 | |
| 192_V | 220_S | 1.27 | 0.99 | |
| 63_N | 66_L | 1.256 | 0.99 | |
| 49_V | 105_T | 1.254 | 0.99 | |
| 34_I | 66_L | 1.25 | 0.99 | |
| 145_N | 350_Q | 1.249 | 0.99 | |
| 57_Q | 96_V | 1.247 | 0.99 | |
| 235_V | 328_L | 1.247 | 0.99 | |
| 398_Q | 405_L | 1.246 | 0.98 | |
| 181_S | 189_R | 1.243 | 0.98 | |
| 132_N | 180_E | 1.242 | 0.98 | |
| 138_A | 141_E | 1.241 | 0.98 | |
| 165_F | 169_C | 1.237 | 0.98 | |
| 60_E | 95_K | 1.233 | 0.98 | |
| 303_L | 307_M | 1.233 | 0.98 | |
| 241_A | 245_G | 1.23 | 0.98 | |
| 121_C | 328_L | 1.225 | 0.98 | |
| 96_V | 103_L | 1.225 | 0.98 | |
| 142_T | 346_L | 1.21 | 0.98 | |
| 172_Y | 252_F | 1.207 | 0.98 | |
| 28_R | 124_T | 1.204 | 0.98 | |
| 393_V | 397_R | 1.204 | 0.98 | |
| 132_N | 176_L | 1.194 | 0.98 | |
| 45_V | 56_A | 1.194 | 0.98 | |
| 135_L | 346_L | 1.194 | 0.98 | |
| 39_A | 215_W | 1.183 | 0.98 | |
| 129_L | 187_L | 1.175 | 0.98 | |
| 245_G | 339_L | 1.171 | 0.98 | |
| 38_V | 66_L | 1.171 | 0.98 | |
| 68_D | 95_K | 1.171 | 0.98 | |
| 435_A | 443_Q | 1.165 | 0.97 | |
| 170_L | 224_N | 1.165 | 0.97 | |
| 131_A | 343_A | 1.164 | 0.97 | |
| 92_L | 103_L | 1.163 | 0.97 | |
| 129_L | 133_R | 1.161 | 0.97 | |
| 33_D | 36_G | 1.16 | 0.97 | |
| 135_L | 343_A | 1.159 | 0.97 | |
| 267_V | 349_I | 1.159 | 0.97 | |
| 407_L | 418_D | 1.154 | 0.97 | |
| 149_A | 356_C | 1.147 | 0.97 | |
| 238_L | 328_L | 1.14 | 0.97 | |
| 56_A | 59_E | 1.134 | 0.97 | |
| 121_C | 238_L | 1.131 | 0.97 | |
| 98_Q | 101_K | 1.13 | 0.97 | |
| 304_T | 308_M | 1.127 | 0.97 | |
| 256_L | 289_L | 1.126 | 0.97 | |
| 148_D | 166_A | 1.121 | 0.97 | |
| 106_G | 208_D | 1.117 | 0.96 | |
| 147_Q | 166_A | 1.114 | 0.96 | |
| 46_T | 52_A | 1.114 | 0.96 | |
| 139_L | 252_F | 1.113 | 0.96 | |
| 141_E | 453_Q | 1.109 | 0.96 | |
| 34_I | 65_L | 1.102 | 0.96 | |
| 165_F | 356_C | 1.095 | 0.96 | |
| 131_A | 134_Q | 1.094 | 0.96 | |
| 31_E | 123_D | 1.093 | 0.96 | |
| 181_S | 185_D | 1.089 | 0.96 | |
| 250_S | 293_R | 1.077 | 0.95 | |
| 239_L | 328_L | 1.074 | 0.95 | |
| 156_H | 290_E | 1.065 | 0.95 | |
| 45_V | 50_L | 1.051 | 0.94 | |
| 210_E | 437_K | 1.05 | 0.94 | |
| 57_Q | 99_L | 1.049 | 0.94 | |
| 122_K | 218_F | 1.047 | 0.94 | |
| 258_F | 318_N | 1.04 | 0.94 | |
| 64_V | 91_K | 1.039 | 0.94 | |
| 53_E | 56_A | 1.037 | 0.94 | |
| 149_A | 353_R | 1.034 | 0.94 | |
| 239_L | 306_M | 1.033 | 0.94 | |
| 232_R | 325_K | 1.032 | 0.94 | |
| 174_E | 178_R | 1.031 | 0.94 | |
| 31_E | 66_L | 1.029 | 0.94 | |
| 125_V | 187_L | 1.028 | 0.94 | |
| 419_E | 423_P | 1.026 | 0.94 | |
| 135_L | 176_L | 1.023 | 0.93 | |
| 159_R | 263_E | 1.022 | 0.93 | |
| 150_V | 431_L | 1.021 | 0.93 | |
| 154_Y | 159_R | 1.018 | 0.93 | |
| 77_L | 84_I | 1.012 | 0.93 | |
| 140_V | 173_V | 1.012 | 0.93 | |
| 142_T | 169_C | 1.012 | 0.93 | |
| 106_G | 207_I | 1.011 | 0.93 | |
| 132_N | 339_L | 1.004 | 0.93 | |
| 191_D | 218_F | 1.004 | 0.93 | |
| 245_G | 335_W | 1.003 | 0.93 | |
| 185_D | 237_E | 1.002 | 0.92 | |
| 35_V | 215_W | 1 | 0.92 | |
| 400_K | 409_E | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2e9fA | 4 | 0.9978 | 100 | 0.021 | Contact Map | 0.751 |
| 1tj7A | 2 | 0.9978 | 100 | 0.028 | Contact Map | 0.696 |
| 1k7wA | 4 | 0.9956 | 100 | 0.029 | Contact Map | 0.732 |
| 1re5A | 4 | 0.9497 | 100 | 0.165 | Contact Map | 0.644 |
| 1q5nA | 1 | 0.9497 | 100 | 0.166 | Contact Map | 0.644 |
| 1c3cA | 2 | 0.9234 | 100 | 0.197 | Contact Map | 0.691 |
| 2pfmA | 2 | 0.9365 | 100 | 0.2 | Contact Map | 0.696 |
| 3c8tA | 1 | 0.9497 | 100 | 0.202 | Contact Map | 0.62 |
| 3r6qA | 8 | 0.9168 | 100 | 0.212 | Contact Map | 0.782 |
| 4admA | 4 | 0.9234 | 100 | 0.213 | Contact Map | 0.705 |
Sequence Conservation (Image Generated using WebLogo v3)