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OPENSEQ.org
FUMC - Fumarate hydratase class II
UniProt: P05042 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10358
Length: 467 (458)
Sequences: 4889
Seq/Len: 10.67
FUMC
Paralog alert: 0.83 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: ARLY ASPA FUMC PUR8
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
60_E 70_A 3.505 1.00
343_N 372_S 3.373 1.00
69_K 133_D 3.343 1.00
53_R 78_D 3.307 1.00
397_R 400_Q 3.254 1.00
427_K 431_E 3.24 1.00
285_A 340_V 2.994 1.00
57_K 74_R 2.979 1.00
446_S 449_E 2.836 1.00
197_L 393_P 2.781 1.00
180_D 395_R 2.711 1.00
161_I 212_L 2.683 1.00
168_T 209_E 2.649 1.00
399_N 403_N 2.629 1.00
221_H 276_Q 2.616 1.00
170_T 389_V 2.524 1.00
310_S 392_E 2.477 1.00
336_L 379_G 2.45 1.00
249_E 252_V 2.428 1.00
156_L 277_A 2.399 1.00
282_K 344_D 2.382 1.00
165_K 216_E 2.37 1.00
174_K 177_A 2.364 1.00
170_T 384_N 2.345 1.00
161_I 216_E 2.337 1.00
61_D 249_E 2.307 1.00
173_E 389_V 2.294 1.00
153_L 223_A 2.264 1.00
310_S 394_N 2.257 1.00
165_K 212_L 2.244 1.00
157_R 219_L 2.212 1.00
60_E 67_E 2.209 1.00
173_E 177_A 2.189 1.00
286_A 341_M 2.166 1.00
113_R 117_L 2.147 1.00
21_L 116_E 2.121 1.00
57_K 253_I 2.103 1.00
223_A 257_P 2.069 1.00
217_Y 220_P 2.031 1.00
433_L 441_A 2.028 1.00
427_K 442_L 2.013 1.00
66_S 69_K 1.97 1.00
312_P 390_G 1.958 1.00
166_T 385_K 1.958 1.00
397_R 401_L 1.956 1.00
288_L 333_L 1.953 1.00
217_Y 221_H 1.936 1.00
163_Q 381_E 1.935 1.00
436_K 451_D 1.933 1.00
67_E 71_S 1.908 1.00
212_L 216_E 1.903 1.00
6_S 15_D 1.902 1.00
168_T 212_L 1.897 1.00
384_N 389_V 1.892 1.00
71_S 75_Q 1.879 1.00
339_Q 368_N 1.847 1.00
166_T 384_N 1.843 1.00
261_A 267_A 1.841 1.00
229_G 267_A 1.834 1.00
170_T 388_A 1.812 1.00
346_A 364_M 1.79 1.00
449_E 452_S 1.748 1.00
400_Q 404_E 1.741 1.00
415_H 449_E 1.739 1.00
395_R 399_N 1.73 1.00
220_P 257_P 1.699 1.00
399_N 457_E 1.696 1.00
178_F 181_I 1.685 1.00
447_E 451_D 1.684 1.00
70_A 74_R 1.658 1.00
330_C 387_C 1.645 1.00
163_Q 377_A 1.634 1.00
210_H 266_E 1.628 1.00
211_N 287_S 1.622 1.00
57_K 249_E 1.618 1.00
347_I 369_F 1.603 1.00
210_H 272_D 1.601 1.00
420_K 423_E 1.588 1.00
245_R 248_D 1.579 1.00
172_N 209_E 1.562 1.00
155_A 377_A 1.552 1.00
43_S 154_L 1.543 1.00
225_L 251_A 1.535 1.00
420_K 444_Y 1.529 1.00
227_L 246_V 1.525 1.00
213_K 220_P 1.489 1.00
214_H 276_Q 1.487 1.00
69_K 127_K 1.487 1.00
56_A 65_L 1.486 1.00
172_N 176_R 1.484 1.00
174_K 388_A 1.484 1.00
427_K 438_A 1.483 1.00
38_E 371_Q 1.48 1.00
79_E 117_L 1.473 1.00
279_G 283_G 1.468 1.00
455_R 458_Q 1.462 1.00
282_K 348_N 1.462 1.00
168_T 208_L 1.458 1.00
394_N 397_R 1.455 1.00
61_D 242_Y 1.445 1.00
433_L 438_A 1.438 1.00
4_V 15_D 1.434 1.00
251_A 257_P 1.426 1.00
22_W 27_Q 1.423 1.00
53_R 74_R 1.413 1.00
164_L 208_L 1.403 0.99
78_D 82_A 1.402 0.99
165_K 169_Q 1.402 0.99
416_I 421_A 1.4 0.99
275_V 283_G 1.394 0.99
297_W 355_N 1.39 0.99
27_Q 30_L 1.373 0.99
197_L 201_I 1.369 0.99
440_L 447_E 1.364 0.99
333_L 379_G 1.357 0.99
78_D 81_L 1.356 0.99
106_M 110_L 1.354 0.99
201_I 204_W 1.353 0.99
292_A 383_F 1.351 0.99
174_K 178_F 1.351 0.99
426_K 430_K 1.348 0.99
167_L 388_A 1.342 0.99
339_Q 371_Q 1.338 0.99
6_S 13_A 1.336 0.99
292_A 333_L 1.333 0.99
309_I 391_I 1.332 0.99
160_L 376_L 1.331 0.99
215_I 284_L 1.329 0.99
72_A 75_Q 1.321 0.99
72_A 118_L 1.314 0.99
161_I 219_L 1.306 0.99
61_D 245_R 1.305 0.99
271_C 362_R 1.301 0.99
53_R 57_K 1.3 0.99
168_T 205_V 1.299 0.99
277_A 369_F 1.282 0.99
431_E 438_A 1.276 0.99
204_W 357_E 1.274 0.99
8_K 13_A 1.274 0.99
115_S 123_G 1.273 0.99
291_I 383_F 1.266 0.99
166_T 389_V 1.265 0.99
164_L 284_L 1.264 0.99
218_S 280_A 1.263 0.99
58_V 249_E 1.263 0.99
204_W 291_I 1.263 0.99
176_R 179_A 1.256 0.99
64_L 136_K 1.251 0.99
242_Y 253_I 1.238 0.98
175_S 205_V 1.234 0.98
385_K 389_V 1.234 0.98
277_A 373_V 1.232 0.98
60_E 71_S 1.23 0.98
448_A 452_S 1.225 0.98
14_I 31_E 1.223 0.98
163_Q 384_N 1.217 0.98
177_A 392_E 1.213 0.98
48_L 143_V 1.211 0.98
280_A 284_L 1.21 0.98
39_K 374_R 1.209 0.98
295_V 330_C 1.206 0.98
213_K 221_H 1.202 0.98
49_A 106_M 1.199 0.98
137_S 238_T 1.188 0.98
152_A 277_A 1.182 0.98
396_E 400_Q 1.176 0.98
46_H 50_L 1.172 0.98
164_L 212_L 1.171 0.98
50_L 154_L 1.171 0.98
42_T 46_H 1.169 0.97
307_G 397_R 1.169 0.97
71_S 74_R 1.167 0.97
166_T 381_E 1.167 0.97
181_I 398_I 1.167 0.97
248_D 252_V 1.166 0.97
54_A 253_I 1.163 0.97
48_L 51_T 1.163 0.97
10_S 422_A 1.16 0.97
60_E 65_L 1.154 0.97
179_A 198_G 1.149 0.97
180_D 198_G 1.145 0.97
224_E 259_V 1.135 0.97
53_R 81_L 1.132 0.97
284_L 380_M 1.132 0.97
434_T 437_A 1.128 0.97
50_L 250_L 1.12 0.96
202_S 263_N 1.119 0.96
47_A 154_L 1.117 0.96
186_R 191_D 1.115 0.96
8_K 419_D 1.114 0.96
49_A 80_V 1.113 0.96
115_S 120_G 1.109 0.96
61_D 67_E 1.108 0.96
21_L 85_H 1.107 0.96
113_R 116_E 1.098 0.96
245_R 249_E 1.097 0.96
154_L 158_K 1.092 0.96
274_L 369_F 1.092 0.96
170_T 173_E 1.086 0.96
241_E 245_R 1.083 0.96
188_H 331_E 1.077 0.95
450_F 454_V 1.076 0.95
439_A 442_L 1.074 0.95
163_Q 166_T 1.072 0.95
289_M 334_T 1.071 0.95
337_C 341_M 1.068 0.95
161_I 165_K 1.068 0.95
75_Q 117_L 1.066 0.95
433_L 437_A 1.065 0.95
213_K 217_Y 1.058 0.95
158_K 219_L 1.057 0.95
418_Y 422_A 1.057 0.95
49_A 81_L 1.056 0.95
43_S 374_R 1.05 0.94
121_V 124_M 1.049 0.94
205_V 209_E 1.048 0.94
341_M 345_V 1.048 0.94
43_S 155_A 1.046 0.94
275_V 351_G 1.045 0.94
137_S 239_H 1.043 0.94
79_E 113_R 1.042 0.94
342_G 346_A 1.038 0.94
284_L 376_L 1.037 0.94
206_A 210_H 1.034 0.94
274_L 347_I 1.033 0.94
156_L 219_L 1.03 0.94
4_V 18_A 1.028 0.94
25_Q 316_P 1.024 0.93
182_V 460_V 1.022 0.93
437_A 441_A 1.02 0.93
62_L 239_H 1.019 0.93
197_L 398_I 1.019 0.93
68_E 72_A 1.013 0.93
195_L 232_V 1.012 0.93
27_Q 31_E 1.009 0.93
171_L 291_I 1.009 0.93
396_E 399_N 1.008 0.93
68_E 71_S 1.007 0.93
153_L 256_A 1.006 0.93
83_G 113_R 1.005 0.93
297_W 306_I 1.004 0.93
17_P 20_K 1.004 0.93
178_F 395_R 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1furA211000.036Contact Map0.705
3r6qA80.99791000.05Contact Map0.81
1yfmA10.98721000.052Contact Map0.653
1vdkA20.99361000.053Contact Map0.715
4hgvA40.99141000.054Contact Map0.751
1jswA40.99791000.055Contact Map0.819
3gtdA20.98721000.063Contact Map0.677
3ocfA40.97861000.067Contact Map0.749
4admA40.9851000.07Contact Map0.732
3e04A40.98931000.072Contact Map0.79
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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