| UniProt: | P0AB89 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11314 | ||
| Length: | 456 (442) | ||
| Sequences: | 4577 | ||
| Seq/Len: | 10.36 |
| PUR8
Paralog alert: 0.81 [within 20: 0.04] - ratio of genomes with paralogs Cluster includes: ARLY ASPA FUMC PUR8 |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 60_A | 116_F | 4.147 | 1.00 | |
| 373_H | 376_D | 3.921 | 1.00 | |
| 48_A | 61_A | 3.374 | 1.00 | |
| 180_I | 369_V | 3.215 | 1.00 | |
| 148_R | 195_Y | 3.158 | 1.00 | |
| 144_L | 195_Y | 3.081 | 1.00 | |
| 45_Q | 236_S | 3.067 | 1.00 | |
| 35_F | 137_T | 2.955 | 1.00 | |
| 148_R | 199_N | 2.878 | 1.00 | |
| 31_G | 351_G | 2.875 | 1.00 | |
| 151_I | 192_E | 2.838 | 1.00 | |
| 163_D | 371_R | 2.834 | 1.00 | |
| 157_L | 160_Q | 2.814 | 1.00 | |
| 144_L | 199_N | 2.797 | 1.00 | |
| 375_L | 379_D | 2.794 | 1.00 | |
| 139_R | 257_L | 2.773 | 1.00 | |
| 265_N | 320_V | 2.745 | 1.00 | |
| 429_P | 435_R | 2.741 | 1.00 | |
| 156_D | 160_Q | 2.672 | 1.00 | |
| 153_G | 365_S | 2.609 | 1.00 | |
| 156_D | 365_S | 2.58 | 1.00 | |
| 141_E | 202_E | 2.545 | 1.00 | |
| 266_T | 321_L | 2.387 | 1.00 | |
| 268_L | 310_S | 2.376 | 1.00 | |
| 195_Y | 199_N | 2.352 | 1.00 | |
| 153_G | 364_V | 2.276 | 1.00 | |
| 149_Q | 361_L | 2.207 | 1.00 | |
| 151_I | 195_Y | 2.185 | 1.00 | |
| 41_V | 68_D | 2.172 | 1.00 | |
| 232_E | 235_T | 2.143 | 1.00 | |
| 81_R | 102_E | 2.116 | 1.00 | |
| 45_Q | 65_G | 2.108 | 1.00 | |
| 48_A | 58_A | 2.067 | 1.00 | |
| 162_R | 453_D | 2.037 | 1.00 | |
| 323_H | 349_G | 2.027 | 1.00 | |
| 396_Y | 404_K | 2.02 | 1.00 | |
| 57_P | 60_A | 2.016 | 1.00 | |
| 161_Y | 164_I | 2.013 | 1.00 | |
| 146_Y | 358_Q | 1.995 | 1.00 | |
| 371_R | 375_L | 1.991 | 1.00 | |
| 73_S | 103_K | 1.963 | 1.00 | |
| 372_D | 376_D | 1.934 | 1.00 | |
| 231_E | 235_T | 1.933 | 1.00 | |
| 49_A | 232_E | 1.927 | 1.00 | |
| 376_D | 380_H | 1.869 | 1.00 | |
| 417_E | 425_G | 1.869 | 1.00 | |
| 197_Q | 256_E | 1.868 | 1.00 | |
| 155_K | 192_E | 1.864 | 1.00 | |
| 198_L | 264_F | 1.86 | 1.00 | |
| 307_F | 363_G | 1.828 | 1.00 | |
| 272_D | 310_S | 1.826 | 1.00 | |
| 373_H | 377_E | 1.823 | 1.00 | |
| 193_R | 252_D | 1.793 | 1.00 | |
| 138_A | 354_L | 1.784 | 1.00 | |
| 34_K | 75_S | 1.77 | 1.00 | |
| 58_A | 62_D | 1.749 | 1.00 | |
| 259_D | 263_R | 1.736 | 1.00 | |
| 255_A | 263_R | 1.728 | 1.00 | |
| 147_W | 264_F | 1.721 | 1.00 | |
| 287_K | 368_E | 1.705 | 1.00 | |
| 180_I | 184_M | 1.69 | 1.00 | |
| 194_Q | 267_I | 1.671 | 1.00 | |
| 400_K | 403_E | 1.667 | 1.00 | |
| 38_Q | 137_T | 1.654 | 1.00 | |
| 151_I | 191_M | 1.603 | 1.00 | |
| 417_E | 422_F | 1.601 | 1.00 | |
| 272_D | 360_T | 1.596 | 1.00 | |
| 151_I | 188_A | 1.592 | 1.00 | |
| 41_V | 71_V | 1.586 | 1.00 | |
| 370_N | 373_H | 1.575 | 1.00 | |
| 147_W | 195_Y | 1.562 | 1.00 | |
| 324_L | 328_L | 1.552 | 1.00 | |
| 155_K | 159_V | 1.551 | 1.00 | |
| 157_L | 161_Y | 1.548 | 1.00 | |
| 69_A | 103_K | 1.547 | 1.00 | |
| 262_A | 327_K | 1.536 | 1.00 | |
| 45_Q | 68_D | 1.533 | 1.00 | |
| 136_K | 203_I | 1.522 | 1.00 | |
| 271_F | 360_T | 1.518 | 1.00 | |
| 148_R | 152_D | 1.511 | 1.00 | |
| 260_C | 264_F | 1.509 | 1.00 | |
| 361_L | 365_S | 1.505 | 1.00 | |
| 41_V | 45_Q | 1.504 | 1.00 | |
| 157_L | 364_V | 1.503 | 1.00 | |
| 228_Q | 231_E | 1.502 | 1.00 | |
| 201_V | 260_C | 1.461 | 1.00 | |
| 257_L | 350_I | 1.456 | 1.00 | |
| 187_V | 271_F | 1.452 | 1.00 | |
| 149_Q | 365_S | 1.444 | 1.00 | |
| 147_W | 191_M | 1.435 | 1.00 | |
| 319_A | 349_G | 1.428 | 1.00 | |
| 63_A | 104_V | 1.426 | 1.00 | |
| 150_L | 361_L | 1.424 | 1.00 | |
| 153_G | 361_L | 1.419 | 1.00 | |
| 48_A | 56_V | 1.415 | 1.00 | |
| 420_K | 437_K | 1.415 | 1.00 | |
| 430_E | 437_K | 1.414 | 1.00 | |
| 153_G | 156_D | 1.405 | 0.99 | |
| 101_K | 114_S | 1.404 | 0.99 | |
| 80_A | 84_T | 1.404 | 0.99 | |
| 162_R | 181_G | 1.404 | 0.99 | |
| 17_G | 24_R | 1.396 | 0.99 | |
| 184_M | 187_V | 1.389 | 0.99 | |
| 169_R | 174_P | 1.372 | 0.99 | |
| 415_D | 422_F | 1.371 | 0.99 | |
| 69_A | 73_S | 1.362 | 0.99 | |
| 286_Q | 370_N | 1.356 | 0.99 | |
| 139_R | 198_L | 1.355 | 0.99 | |
| 445_I | 449_I | 1.349 | 0.99 | |
| 440_T | 443_N | 1.346 | 0.99 | |
| 135_L | 257_L | 1.345 | 0.99 | |
| 407_E | 415_D | 1.34 | 0.99 | |
| 275_V | 307_F | 1.338 | 0.99 | |
| 44_L | 56_V | 1.337 | 0.99 | |
| 411_G | 415_D | 1.335 | 0.99 | |
| 217_H | 228_Q | 1.322 | 0.99 | |
| 146_Y | 354_L | 1.318 | 0.99 | |
| 28_S | 335_R | 1.311 | 0.99 | |
| 203_I | 240_Q | 1.302 | 0.99 | |
| 159_V | 162_R | 1.299 | 0.99 | |
| 34_K | 38_Q | 1.296 | 0.99 | |
| 396_Y | 401_P | 1.29 | 0.99 | |
| 99_F | 102_E | 1.286 | 0.99 | |
| 99_F | 103_K | 1.284 | 0.99 | |
| 163_D | 449_I | 1.283 | 0.99 | |
| 262_A | 324_L | 1.273 | 0.99 | |
| 39_V | 126_I | 1.272 | 0.99 | |
| 161_Y | 371_R | 1.267 | 0.99 | |
| 34_K | 71_V | 1.267 | 0.99 | |
| 146_Y | 149_Q | 1.267 | 0.99 | |
| 196_R | 200_Q | 1.263 | 0.99 | |
| 317_S | 321_L | 1.256 | 0.99 | |
| 144_L | 148_R | 1.256 | 0.99 | |
| 41_V | 65_G | 1.254 | 0.99 | |
| 160_Q | 368_E | 1.254 | 0.99 | |
| 155_K | 188_A | 1.251 | 0.99 | |
| 59_F | 63_A | 1.241 | 0.98 | |
| 310_S | 360_T | 1.236 | 0.98 | |
| 157_L | 184_M | 1.233 | 0.98 | |
| 436_L | 439_M | 1.23 | 0.98 | |
| 386_A | 390_Q | 1.223 | 0.98 | |
| 154_I | 271_F | 1.221 | 0.98 | |
| 36_R | 126_I | 1.217 | 0.98 | |
| 217_H | 222_P | 1.215 | 0.98 | |
| 164_I | 374_L | 1.212 | 0.98 | |
| 251_H | 343_L | 1.212 | 0.98 | |
| 163_D | 181_G | 1.208 | 0.98 | |
| 120_A | 229_F | 1.208 | 0.98 | |
| 65_G | 69_A | 1.206 | 0.98 | |
| 164_I | 371_R | 1.199 | 0.98 | |
| 424_D | 437_K | 1.196 | 0.98 | |
| 184_M | 374_L | 1.192 | 0.98 | |
| 228_Q | 232_E | 1.188 | 0.98 | |
| 275_V | 367_L | 1.185 | 0.98 | |
| 31_G | 138_A | 1.184 | 0.98 | |
| 348_V | 352_Y | 1.179 | 0.98 | |
| 407_E | 426_L | 1.167 | 0.97 | |
| 138_A | 142_V | 1.166 | 0.97 | |
| 250_P | 267_I | 1.163 | 0.97 | |
| 169_R | 282_N | 1.16 | 0.97 | |
| 152_D | 156_D | 1.158 | 0.97 | |
| 185_A | 242_N | 1.158 | 0.97 | |
| 37_V | 71_V | 1.157 | 0.97 | |
| 150_L | 191_M | 1.148 | 0.97 | |
| 61_A | 65_G | 1.147 | 0.97 | |
| 172_G | 277_G | 1.146 | 0.97 | |
| 46_K | 232_E | 1.139 | 0.97 | |
| 136_K | 240_Q | 1.128 | 0.97 | |
| 286_Q | 368_E | 1.128 | 0.97 | |
| 161_Y | 369_V | 1.127 | 0.97 | |
| 183_E | 278_Y | 1.126 | 0.97 | |
| 257_L | 261_V | 1.124 | 0.97 | |
| 193_R | 245_T | 1.124 | 0.97 | |
| 188_A | 192_E | 1.114 | 0.96 | |
| 186_N | 270_D | 1.113 | 0.96 | |
| 375_L | 442_A | 1.112 | 0.96 | |
| 210_A | 297_T | 1.111 | 0.96 | |
| 316_L | 352_Y | 1.109 | 0.96 | |
| 34_K | 137_T | 1.104 | 0.96 | |
| 321_L | 329_P | 1.103 | 0.96 | |
| 29_E | 83_K | 1.101 | 0.96 | |
| 131_H | 254_I | 1.1 | 0.96 | |
| 189_Y | 241_W | 1.1 | 0.96 | |
| 166_L | 374_L | 1.096 | 0.96 | |
| 447_R | 451_M | 1.096 | 0.96 | |
| 136_K | 239_I | 1.096 | 0.96 | |
| 255_A | 330_V | 1.093 | 0.96 | |
| 153_G | 157_L | 1.09 | 0.96 | |
| 68_D | 71_V | 1.077 | 0.95 | |
| 319_A | 348_V | 1.073 | 0.95 | |
| 417_E | 421_Q | 1.071 | 0.95 | |
| 147_W | 198_L | 1.07 | 0.95 | |
| 159_V | 163_D | 1.069 | 0.95 | |
| 154_I | 184_M | 1.069 | 0.95 | |
| 407_E | 422_F | 1.068 | 0.95 | |
| 49_A | 58_A | 1.06 | 0.95 | |
| 180_I | 374_L | 1.06 | 0.95 | |
| 150_L | 364_V | 1.059 | 0.95 | |
| 139_R | 202_E | 1.058 | 0.95 | |
| 168_S | 178_S | 1.053 | 0.95 | |
| 264_F | 353_A | 1.051 | 0.94 | |
| 325_A | 329_P | 1.048 | 0.94 | |
| 149_Q | 358_Q | 1.044 | 0.94 | |
| 395_R | 435_R | 1.042 | 0.94 | |
| 53_I | 119_F | 1.042 | 0.94 | |
| 48_A | 62_D | 1.041 | 0.94 | |
| 154_I | 188_A | 1.04 | 0.94 | |
| 63_A | 113_V | 1.038 | 0.94 | |
| 410_R | 414_V | 1.036 | 0.94 | |
| 396_Y | 400_K | 1.033 | 0.94 | |
| 59_F | 62_D | 1.031 | 0.94 | |
| 69_A | 100_L | 1.022 | 0.93 | |
| 139_R | 144_L | 1.021 | 0.93 | |
| 144_L | 202_E | 1.02 | 0.93 | |
| 205_G | 234_V | 1.02 | 0.93 | |
| 268_L | 360_T | 1.016 | 0.93 | |
| 174_P | 381_N | 1.007 | 0.93 | |
| 197_Q | 252_D | 1.004 | 0.93 | |
| 174_P | 282_N | 1.002 | 0.92 | |
| 255_A | 327_K | 1.001 | 0.92 | |
| 269_I | 311_E | 1 | 0.92 | |
| 424_D | 430_E | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2ptrA | 2 | 0.9846 | 100 | 0.089 | Contact Map | 0.533 |
| 3bhgA | 1 | 0.9846 | 100 | 0.102 | Contact Map | 0.488 |
| 2qgaB | 2 | 0.9825 | 100 | 0.126 | Contact Map | 0.575 |
| 4efcA | 2 | 0.9759 | 100 | 0.156 | Contact Map | 0.561 |
| 1re5A | 4 | 0.9408 | 100 | 0.156 | Contact Map | 0.632 |
| 1c3cA | 2 | 0.9079 | 100 | 0.159 | Contact Map | 0.662 |
| 2pfmA | 2 | 0.9298 | 100 | 0.162 | Contact Map | 0.688 |
| 3c8tA | 1 | 0.9364 | 100 | 0.163 | Contact Map | 0.614 |
| 1q5nA | 1 | 0.9474 | 100 | 0.165 | Contact Map | 0.658 |
| 4eeiA | 2 | 0.9035 | 100 | 0.184 | Contact Map | 0.713 |
Sequence Conservation (Image Generated using WebLogo v3)