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OPENSEQ.org

INSE1 - Transposase InsE for insertion sequence IS3A
UniProt: P0CF66 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG40005
Length: 99 (91)
Sequences: 1353
Seq/Len: 14.87

INSE1
Paralog alert: 0.62 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: INSE1 INSE2 INSE3 INSE4 INSE5 INSN2 YKGN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
76_Q 81_D 5.191 1.00
69_E 74_K 4.48 1.00
77_L 80_R 4.257 1.00
23_A 39_L 2.681 1.00
17_P 21_S 2.338 1.00
23_A 46_L 2.262 1.00
66_M 70_I 2.104 1.00
44_S 47_Y 2.06 1.00
33_T 37_R 1.937 1.00
73_L 77_L 1.901 1.00
91_A 95_A 1.885 1.00
48_N 52_K 1.877 1.00
69_E 72_R 1.815 1.00
32_V 47_Y 1.771 1.00
90_A 94_F 1.558 1.00
27_A 50_R 1.538 1.00
68_T 72_R 1.522 1.00
42_Y 45_Q 1.513 1.00
82_E 86_I 1.427 1.00
92_T 95_A 1.388 0.99
21_S 25_K 1.362 0.99
70_I 74_K 1.343 0.99
22_E 25_K 1.295 0.99
25_K 29_R 1.291 0.99
34_A 38_E 1.275 0.99
67_S 70_I 1.258 0.99
72_R 76_Q 1.234 0.98
78_A 82_E 1.19 0.98
86_I 90_A 1.19 0.98
84_L 87_L 1.185 0.98
70_I 73_L 1.169 0.97
26_L 35_A 1.146 0.97
85_A 89_K 1.145 0.97
89_K 92_T 1.14 0.97
62_R 67_S 1.133 0.97
82_E 89_K 1.125 0.97
80_R 84_L 1.119 0.96
32_V 36_A 1.11 0.96
88_Q 93_Y 1.103 0.96
79_E 82_E 1.075 0.95
21_S 53_Q 1.023 0.93
50_R 54_Q 1.022 0.93
28_E 54_Q 1.016 0.93
76_Q 79_E 1.01 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2rn7A10.919299.80.312Contact Map0.287
2jn6A10.909199.60.426Contact Map0.408
1hlvA10.909199.10.559Contact Map0.506
2elhA10.757698.50.634Contact Map0.171
2oa4A10.79898.50.635Contact Map0.639
2ao9A90.979898.50.64Contact Map0.452
2gloA10.545598.50.643Contact Map0.721
4dyqA20.828398.30.654Contact Map0.54
1pdnC10.959698.10.673Contact Map0.695
2k27A10.9596980.681Contact Map0.413

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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