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OPENSEQ.org

INSN2 - Transposase InsN for insertion sequence element IS911B
UniProt: P39212 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:
Length: 100 (88)
Sequences: 1290
Seq/Len: 14.66

INSN2
Paralog alert: 0.62 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: INSE1 INSE2 INSE3 INSE4 INSE5 INSN2 YKGN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
85_K 90_E 5.35 1.00
78_E 83_R 4.693 1.00
86_L 89_I 4.506 1.00
26_S 44_M 2.739 1.00
20_A 24_R 2.515 1.00
26_S 51_M 2.199 1.00
53_R 57_Q 2.093 1.00
82_L 86_L 2.09 1.00
49_S 52_T 2.078 1.00
38_A 42_K 2.065 1.00
75_E 79_I 1.954 1.00
37_V 52_T 1.919 1.00
78_E 81_K 1.887 1.00
30_V 55_V 1.869 1.00
77_I 81_K 1.798 1.00
28_Q 32_D 1.62 1.00
91_M 95_I 1.524 1.00
25_E 28_Q 1.51 1.00
79_I 83_R 1.431 1.00
91_M 98_R 1.387 0.99
94_E 98_R 1.38 0.99
47_G 50_T 1.356 0.99
39_D 43_A 1.347 0.99
93_N 96_L 1.334 0.99
35_Y 40_A 1.326 0.99
24_R 28_Q 1.278 0.99
79_I 82_L 1.26 0.99
76_Q 79_I 1.255 0.99
88_R 91_M 1.244 0.98
95_I 99_L 1.215 0.98
35_Y 39_D 1.213 0.98
71_P 76_Q 1.208 0.98
81_K 85_K 1.178 0.98
89_I 93_N 1.154 0.97
85_K 88_R 1.122 0.97
18_F 22_F 1.06 0.95
37_V 41_A 1.054 0.95
35_Y 43_A 1.052 0.95
74_P 77_I 1.013 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2rn7A10.8799.80.331Contact Map0.298
2jn6A10.8899.70.371Contact Map0.415
1hlvA10.88990.569Contact Map0.59
2ao9A90.9598.70.611Contact Map0.566
2gloA10.5698.60.621Contact Map0.683
2oa4A10.8298.60.625Contact Map0.699
4dyqA20.7598.60.629Contact Map0.598
2elhA10.8298.50.633Contact Map0.241
2k27A10.9998.30.66Contact Map0.472
1pdnC10.9598.30.663Contact Map0.766

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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