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GATY - D-tagatose-1,6-bisphosphate aldolase subunit GatY
UniProt: P0C8J6 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12419
Length: 284 (284)
Sequences: 1911
Seq/Len: 6.73

GATY
Paralog alert: 0.36 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: ALF GATY KBAY YDJI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
162_E 166_A 3.908 1.00
40_N 268_R 3.874 1.00
110_F 162_E 3.35 1.00
43_A 280_C 3.331 1.00
119_E 122_D 3.307 1.00
40_N 272_S 3.277 1.00
245_N 249_E 2.968 1.00
12_N 16_G 2.749 1.00
91_A 123_F 2.661 1.00
12_N 18_Y 2.64 1.00
161_R 165_E 2.634 1.00
36_E 268_R 2.625 1.00
195_E 199_Q 2.609 1.00
190_D 193_R 2.604 1.00
41_L 276_A 2.603 1.00
34_V 45_V 2.515 1.00
109_P 112_Q 2.496 1.00
115_S 119_E 2.379 1.00
95_R 123_F 2.324 1.00
39_A 74_H 2.311 1.00
215_T 277_D 2.244 1.00
176_I 194_L 2.202 1.00
91_A 95_R 2.144 1.00
265_S 269_D 2.091 1.00
276_A 281_E 2.084 1.00
214_S 217_D 2.05 1.00
49_G 98_V 2.05 1.00
110_F 114_I 2.002 1.00
103_I 116_R 1.976 1.00
118_K 122_D 1.952 1.00
262_S 265_S 1.945 1.00
195_E 220_Q 1.913 1.00
41_L 281_E 1.906 1.00
242_A 266_A 1.877 1.00
196_N 199_Q 1.846 1.00
95_R 127_F 1.838 1.00
94_V 129_V 1.837 1.00
11_N 15_R 1.822 1.00
268_R 272_S 1.819 1.00
161_R 200_W 1.817 1.00
7_K 11_N 1.815 1.00
125_H 170_D 1.767 1.00
195_E 224_L 1.756 1.00
122_D 126_R 1.753 1.00
41_L 272_S 1.744 1.00
64_A 68_A 1.711 1.00
191_F 220_Q 1.686 1.00
9_M 78_A 1.684 1.00
6_T 171_S 1.643 1.00
105_A 108_L 1.643 1.00
118_K 166_A 1.642 1.00
111_A 166_A 1.64 1.00
220_Q 223_K 1.639 1.00
6_T 78_A 1.636 1.00
64_A 67_S 1.625 1.00
205_L 226_I 1.62 1.00
22_A 48_A 1.591 1.00
159_Q 162_E 1.571 1.00
220_Q 224_L 1.527 0.99
269_D 272_S 1.518 0.99
32_Q 264_K 1.508 0.99
243_L 259_Y 1.503 0.99
125_H 128_D 1.479 0.99
14_Q 198_R 1.472 0.99
215_T 219_Q 1.468 0.99
66_V 79_I 1.465 0.99
275_I 281_E 1.462 0.99
241_Q 245_N 1.451 0.99
110_F 159_Q 1.441 0.99
156_N 159_Q 1.411 0.99
110_F 166_A 1.398 0.99
25_I 47_I 1.389 0.99
3_V 99_R 1.385 0.98
242_A 245_N 1.368 0.98
123_F 127_F 1.365 0.98
266_A 269_D 1.364 0.98
16_G 283_R 1.357 0.98
35_V 77_L 1.355 0.98
14_Q 227_C 1.348 0.98
35_V 73_Y 1.342 0.98
253_A 258_D 1.327 0.98
45_V 77_L 1.322 0.98
121_V 131_V 1.315 0.98
39_A 42_H 1.3 0.97
108_L 112_Q 1.288 0.97
120_V 131_V 1.27 0.97
273_K 277_D 1.269 0.97
158_A 200_W 1.257 0.97
31_M 69_M 1.25 0.97
68_A 71_K 1.242 0.96
117_V 133_A 1.225 0.96
223_K 279_G 1.224 0.96
51_P 89_D 1.22 0.96
246_Y 250_H 1.206 0.96
178_T 213_L 1.206 0.96
17_G 223_K 1.2 0.95
269_D 273_K 1.196 0.95
191_F 224_L 1.192 0.95
8_Q 12_N 1.191 0.95
39_A 73_Y 1.187 0.95
21_P 271_V 1.174 0.95
215_T 273_K 1.172 0.95
25_I 31_M 1.17 0.95
111_A 162_E 1.15 0.94
222_I 278_C 1.142 0.94
192_S 196_N 1.141 0.94
80_H 100_S 1.125 0.93
108_L 116_R 1.122 0.93
36_E 264_K 1.122 0.93
272_S 276_A 1.114 0.92
31_M 47_I 1.112 0.92
232_A 236_K 1.107 0.92
112_Q 115_S 1.103 0.92
26_H 30_T 1.095 0.92
91_A 127_F 1.093 0.92
235_L 267_M 1.072 0.90
193_R 196_N 1.055 0.89
111_A 115_S 1.053 0.89
140_G 143_D 1.049 0.89
270_V 273_K 1.049 0.89
147_V 152_A 1.043 0.89
116_R 119_E 1.042 0.89
25_I 34_V 1.04 0.89
87_F 119_E 1.034 0.88
21_P 267_M 1.031 0.88
37_T 41_L 1.008 0.86
101_V 124_C 1.008 0.86
219_Q 277_D 1.008 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gvfA211000.046Contact Map0.742
3q94A20.9931000.052Contact Map0.806
3n9rA80.99651000.054Contact Map0.784
1rvgA40.9931000.056Contact Map0.823
2iswA20.98941000.06Contact Map0.774
3elfA111000.104Contact Map0.619
3pm6A20.97891000.116Contact Map0.773
3qm3A811000.119Contact Map0.73
1dosA211000.12Contact Map0.73
3txvA10.96481000.252Contact Map0.319

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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