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KBAY - D-tagatose-1,6-bisphosphate aldolase subunit KbaY
UniProt: P0AB74 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12768
Length: 286 (283)
Sequences: 1900
Seq/Len: 6.71
KBAY
Paralog alert: 0.36 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: ALF GATY KBAY YDJI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
162_R 166_L 3.948 1.00
40_E 268_K 3.868 1.00
110_F 162_R 3.416 1.00
43_S 280_S 3.348 1.00
119_S 122_D 3.319 1.00
40_E 272_R 3.254 1.00
245_A 249_E 2.99 1.00
195_A 199_E 2.754 1.00
12_D 18_Y 2.723 1.00
12_D 16_N 2.705 1.00
91_R 123_F 2.667 1.00
41_M 276_N 2.627 1.00
190_D 193_R 2.601 1.00
36_E 268_K 2.58 1.00
161_K 165_E 2.575 1.00
34_I 45_V 2.543 1.00
109_P 112_E 2.526 1.00
115_K 119_S 2.334 1.00
95_H 123_F 2.309 1.00
39_S 74_N 2.307 1.00
176_I 194_L 2.25 1.00
215_D 277_V 2.244 1.00
276_N 281_A 2.138 1.00
265_D 269_E 2.095 1.00
49_G 98_V 2.091 1.00
91_R 95_H 2.045 1.00
214_P 217_F 2.011 1.00
103_I 116_L 1.995 1.00
110_F 114_V 1.988 1.00
41_M 281_A 1.969 1.00
262_V 265_D 1.941 1.00
118_K 122_D 1.925 1.00
195_A 220_R 1.896 1.00
242_A 266_A 1.866 1.00
11_Q 15_A 1.845 1.00
7_K 11_Q 1.826 1.00
95_H 127_Q 1.821 1.00
195_A 224_L 1.815 1.00
268_K 272_R 1.803 1.00
6_T 78_A 1.77 1.00
41_M 272_R 1.761 1.00
94_V 129_C 1.754 1.00
161_K 200_V 1.753 1.00
125_H 170_D 1.726 1.00
9_L 78_A 1.724 1.00
118_K 166_L 1.714 1.00
122_D 126_S 1.705 1.00
191_F 220_R 1.69 1.00
64_A 68_A 1.686 1.00
105_G 108_F 1.667 1.00
64_A 67_S 1.641 1.00
220_R 223_E 1.621 1.00
159_E 162_R 1.613 1.00
6_T 171_S 1.604 1.00
205_L 226_V 1.6 1.00
22_A 48_A 1.597 1.00
196_E 199_E 1.566 0.99
220_R 224_L 1.552 0.99
243_V 259_Y 1.551 0.99
32_Q 264_M 1.521 0.99
269_E 272_R 1.501 0.99
111_A 166_L 1.494 0.99
110_F 159_E 1.487 0.99
275_I 281_A 1.484 0.99
125_H 128_D 1.482 0.99
215_D 219_R 1.481 0.99
16_N 283_R 1.438 0.99
66_C 79_L 1.422 0.99
25_I 47_L 1.402 0.99
241_G 245_A 1.398 0.99
35_L 73_Y 1.391 0.99
253_G 258_Y 1.374 0.98
14_Q 227_T 1.369 0.98
3_I 99_R 1.366 0.98
242_A 245_A 1.365 0.98
156_D 159_E 1.361 0.98
35_L 77_L 1.36 0.98
266_A 269_E 1.342 0.98
110_F 166_L 1.341 0.98
45_V 77_L 1.328 0.98
123_F 127_Q 1.319 0.98
108_F 112_E 1.303 0.98
121_V 131_V 1.301 0.97
14_Q 198_R 1.295 0.97
158_Q 200_V 1.291 0.97
17_G 223_E 1.281 0.97
31_I 69_Y 1.275 0.97
120_V 131_V 1.275 0.97
39_S 42_R 1.271 0.97
273_N 277_V 1.265 0.97
8_Y 12_D 1.261 0.97
223_E 279_G 1.237 0.96
117_V 133_A 1.212 0.96
51_P 89_D 1.211 0.96
192_Q 196_E 1.21 0.96
178_T 213_V 1.203 0.95
191_F 224_L 1.199 0.95
39_S 73_Y 1.183 0.95
215_D 273_N 1.181 0.95
269_E 273_N 1.18 0.95
246_W 250_N 1.18 0.95
21_P 271_V 1.17 0.95
36_E 264_M 1.164 0.94
68_A 71_T 1.161 0.94
222_I 278_C 1.156 0.94
25_I 31_I 1.155 0.94
272_R 276_N 1.15 0.94
108_F 116_L 1.126 0.93
80_H 100_S 1.121 0.93
111_A 162_R 1.117 0.93
232_A 236_K 1.116 0.93
235_L 267_M 1.113 0.92
31_I 47_L 1.105 0.92
112_E 115_K 1.101 0.92
26_H 30_T 1.089 0.91
42_R 284_I 1.084 0.91
101_A 124_C 1.075 0.91
140_G 143_D 1.074 0.91
25_I 34_I 1.045 0.89
91_R 127_Q 1.04 0.89
116_L 119_S 1.033 0.88
197_I 205_L 1.031 0.88
247_F 259_Y 1.023 0.87
31_I 66_C 1.02 0.87
193_R 197_I 1.018 0.87
21_P 267_M 1.017 0.87
133_A 169_V 1.015 0.87
270_V 273_N 1.015 0.87
193_R 196_E 1.013 0.87
38_C 275_I 1.008 0.86
244_K 247_F 1.007 0.86
67_S 71_T 1.006 0.86
94_V 123_F 1.002 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gvfA211000.047Contact Map0.746
3q94A20.9861000.058Contact Map0.817
3n9rA80.98951000.061Contact Map0.796
1rvgA40.9861000.063Contact Map0.832
2iswA20.98951000.067Contact Map0.789
3elfA111000.111Contact Map0.626
3pm6A20.9791000.124Contact Map0.794
1dosA20.9931000.125Contact Map0.743
3qm3A80.9931000.129Contact Map0.733
3txvA10.9651000.263Contact Map0.318
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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