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OPENSEQ.org
TFAE - Tail fiber assembly protein homolog from lambdoid prophage e14
UniProt: P09153 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11120
Length: 200 (199)
Sequences: 209
Seq/Len: 1.05
TFAE
Paralog alert: 0.64 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: TFAE TFAQ TFAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
138_Q 142_L 2.742 1.00
155_L 178_I 2.504 0.99
153_I 163_L 2.264 0.98
51_D 64_R 2.24 0.98
156_K 163_L 1.959 0.95
179_D 183_A 1.937 0.95
167_E 179_D 1.803 0.92
163_L 179_D 1.803 0.92
156_K 183_A 1.787 0.91
163_L 167_E 1.747 0.90
99_Y 103_T 1.723 0.89
163_L 183_A 1.668 0.87
167_E 183_A 1.645 0.86
165_Q 168_T 1.595 0.84
158_Q 163_L 1.589 0.83
49_C 64_R 1.573 0.82
66_A 85_T 1.564 0.82
28_R 72_E 1.554 0.81
163_L 175_L 1.549 0.81
181_V 184_T 1.538 0.80
156_K 160_G 1.526 0.80
12_A 16_G 1.481 0.77
153_I 179_D 1.466 0.76
155_L 158_Q 1.465 0.76
153_I 175_L 1.435 0.74
128_H 132_V 1.425 0.73
175_L 179_D 1.413 0.72
174_V 177_Y 1.388 0.70
11_I 17_D 1.378 0.69
156_K 179_D 1.372 0.69
155_L 163_L 1.363 0.68
37_Y 83_Y 1.36 0.68
82_V 103_T 1.345 0.66
101_E 125_E 1.344 0.66
157_L 160_G 1.339 0.66
158_Q 175_L 1.332 0.65
110_S 113_D 1.328 0.65
38_L 41_G 1.317 0.64
156_K 161_R 1.313 0.64
136_E 186_T 1.313 0.64
157_L 163_L 1.31 0.63
80_E 99_Y 1.31 0.63
175_L 183_A 1.299 0.62
75_P 98_D 1.296 0.62
153_I 156_K 1.293 0.62
155_L 175_L 1.272 0.60
23_Y 49_C 1.26 0.59
57_K 73_Y 1.253 0.58
156_K 159_A 1.252 0.58
16_G 41_G 1.251 0.58
154_Q 158_Q 1.225 0.56
155_L 159_A 1.194 0.53
16_G 36_E 1.189 0.52
175_L 178_I 1.184 0.52
153_I 183_A 1.184 0.52
195_P 198_P 1.184 0.52
36_E 42_V 1.17 0.51
6_L 43_G 1.165 0.50
179_D 182_T 1.156 0.49
153_I 174_V 1.155 0.49
11_I 22_N 1.144 0.48
113_D 122_T 1.141 0.48
168_T 184_T 1.138 0.48
2_H 5_I 1.135 0.47
163_L 182_T 1.135 0.47
28_R 66_A 1.13 0.47
128_H 131_A 1.122 0.46
177_Y 195_P 1.114 0.45
17_D 23_Y 1.111 0.45
132_V 148_A 1.106 0.45
17_D 49_C 1.104 0.44
2_H 7_N 1.104 0.44
8_S 11_I 1.102 0.44
125_E 166_A 1.101 0.44
167_E 182_T 1.093 0.43
12_A 41_G 1.088 0.43
28_R 64_R 1.081 0.42
3_K 8_S 1.078 0.42
165_Q 174_V 1.076 0.42
181_V 193_I 1.069 0.41
12_A 20_V 1.068 0.41
156_K 167_E 1.067 0.41
61_A 66_A 1.066 0.41
158_Q 164_T 1.06 0.40
174_V 195_P 1.057 0.40
178_I 183_A 1.051 0.40
62_I 73_Y 1.049 0.39
36_E 48_S 1.048 0.39
142_L 152_L 1.043 0.39
49_C 63_C 1.042 0.39
112_Y 130_A 1.042 0.39
14_K 17_D 1.041 0.39
72_E 104_T 1.041 0.39
49_C 68_F 1.03 0.38
158_Q 183_A 1.023 0.37
4_A 11_I 1.018 0.37
46_A 100_P 1.017 0.37
110_S 122_T 1.015 0.36
167_E 175_L 1.008 0.36
5_I 9_D 1.007 0.36
155_L 160_G 1.004 0.35
11_I 16_G 1.004 0.35
163_L 174_V 1 0.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2kz6A10.49599.70.77Contact Map0.199
2c7hA10.26517.10.962Contact Map0.12
3kvpA60.2417.10.962Contact Map0.214
2z14A10.24560.969Contact Map0.104
4mmsB30.354.40.971Contact Map0.079
3dsmA10.484.40.971Contact Map0.053
4ksfA10.3254.20.971Contact Map0.207
2oizA20.454.10.971Contact Map0.017
1ri6A10.33.70.972Contact Map0.068
3a1mA60.3753.50.972Contact Map0.512
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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