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MCP4 - Methyl-accepting chemotaxis protein IV
UniProt: P07018 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10987
Length: 533 (516)
Sequences: 4981
Seq/Len: 9.65
MCP4
Paralog alert: 0.85 [within 20: 0.30] - ratio of genomes with paralogs
Cluster includes: AER MCP1 MCP2 MCP3 MCP4
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
143_Q 146_D 4.522 1.00
227_S 232_N 3.979 1.00
241_G 246_T 3.844 1.00
6_R 9_T 3.145 1.00
105_M 122_E 2.869 1.00
221_I 249_F 2.457 1.00
175_E 179_A 2.294 1.00
95_T 99_T 2.282 1.00
253_K 256_Q 2.252 1.00
26_N 196_I 2.23 1.00
401_N 404_S 2.162 1.00
88_T 92_A 2.074 1.00
161_V 165_A 2.054 1.00
406_S 410_A 2.052 1.00
168_L 172_H 2.022 1.00
190_L 194_S 1.98 1.00
99_T 103_S 1.971 1.00
227_S 235_R 1.896 1.00
116_G 120_E 1.852 1.00
8_S 12_F 1.852 1.00
217_P 244_E 1.834 1.00
226_D 247_A 1.816 1.00
221_I 252_L 1.814 1.00
321_Q 324_E 1.808 1.00
134_H 137_T 1.784 1.00
214_I 217_P 1.777 1.00
133_E 137_T 1.768 1.00
228_I 255_M 1.755 1.00
137_T 141_S 1.752 1.00
27_G 31_W 1.743 1.00
338_V 342_T 1.742 1.00
222_G 251_S 1.742 1.00
172_H 176_A 1.725 1.00
138_W 143_Q 1.698 1.00
212_K 216_Q 1.697 1.00
226_D 254_T 1.683 1.00
369_F 380_V 1.667 1.00
37_L 185_Y 1.663 1.00
102_K 106_A 1.662 1.00
79_P 82_D 1.635 1.00
10_T 213_M 1.626 1.00
429_K 433_N 1.626 1.00
10_T 243_N 1.617 1.00
179_A 183_R 1.609 1.00
150_A 154_G 1.602 1.00
225_F 255_M 1.599 1.00
91_R 95_T 1.594 1.00
488_E 492_V 1.585 1.00
40_L 43_V 1.566 1.00
189_A 193_I 1.554 1.00
342_T 433_N 1.548 1.00
41_N 45_Q 1.542 1.00
7_I 218_L 1.541 1.00
314_Q 317_D 1.539 1.00
193_I 197_I 1.529 1.00
96_Q 99_T 1.525 1.00
425_Q 429_K 1.521 1.00
119_K 123_K 1.512 1.00
164_E 168_L 1.51 1.00
468_Q 471_Q 1.509 1.00
92_A 96_Q 1.5 1.00
344_T 435_A 1.495 1.00
362_S 366_G 1.491 1.00
350_I 427_G 1.487 1.00
225_F 251_S 1.481 1.00
332_T 440_D 1.48 1.00
120_E 162_N 1.478 1.00
134_H 151_P 1.476 1.00
225_F 248_I 1.465 1.00
502_D 506_S 1.459 1.00
197_I 201_I 1.459 1.00
265_D 503_H 1.456 1.00
315_N 459_S 1.449 1.00
236_P 260_R 1.449 1.00
185_Y 189_A 1.448 1.00
253_K 257_Q 1.438 1.00
122_E 126_A 1.437 1.00
336_G 441_I 1.436 1.00
226_D 230_A 1.432 1.00
475_Q 478_Q 1.429 1.00
8_S 211_R 1.428 1.00
134_H 138_W 1.427 1.00
124_S 162_N 1.417 0.99
99_T 102_K 1.414 0.99
446_T 450_D 1.413 0.99
436_A 440_D 1.409 0.99
356_K 359_D 1.407 0.99
243_N 246_T 1.403 0.99
102_K 105_M 1.4 0.99
33_F 36_D 1.397 0.99
307_Q 310_A 1.395 0.99
123_K 127_R 1.395 0.99
337_G 442_V 1.392 0.99
328_N 331_T 1.384 0.99
432_N 436_A 1.383 0.99
436_A 439_I 1.381 0.99
343_M 431_V 1.38 0.99
335_A 440_D 1.376 0.99
194_S 198_V 1.374 0.99
211_R 215_V 1.368 0.99
84_K 88_T 1.365 0.99
306_E 310_A 1.363 0.99
331_T 335_A 1.359 0.99
447_R 450_D 1.358 0.99
244_E 247_A 1.353 0.99
223_S 226_D 1.351 0.99
247_A 250_A 1.351 0.99
261_G 265_D 1.346 0.99
126_A 130_N 1.345 0.99
236_P 253_K 1.342 0.99
138_W 146_D 1.342 0.99
24_G 28_M 1.341 0.99
22_Q 25_S 1.341 0.99
25_S 29_S 1.341 0.99
98_T 102_K 1.333 0.99
120_E 124_S 1.327 0.99
96_Q 100_L 1.325 0.99
130_N 134_H 1.318 0.99
213_M 217_P 1.314 0.99
225_F 252_L 1.311 0.99
356_K 412_E 1.31 0.99
347_M 350_I 1.295 0.99
137_T 140_E 1.295 0.99
437_T 441_I 1.293 0.99
14_I 18_C 1.293 0.99
379_A 400_R 1.292 0.99
151_P 154_G 1.29 0.99
176_A 180_Q 1.287 0.99
88_T 91_R 1.287 0.99
236_P 256_Q 1.284 0.99
503_H 506_S 1.278 0.99
349_E 352_T 1.276 0.99
245_I 249_F 1.276 0.99
279_E 282_A 1.274 0.99
187_I 191_V 1.271 0.99
29_S 192_F 1.27 0.99
485_S 488_E 1.268 0.99
291_T 487_V 1.264 0.99
379_A 397_G 1.264 0.99
221_I 248_I 1.263 0.99
400_R 405_R 1.262 0.99
333_A 442_V 1.26 0.99
341_S 345_H 1.253 0.98
313_G 467_E 1.251 0.98
162_N 165_A 1.251 0.98
58_A 61_L 1.243 0.98
228_I 256_Q 1.238 0.98
349_E 423_R 1.237 0.98
324_E 328_N 1.234 0.98
87_M 140_E 1.229 0.98
279_E 489_E 1.229 0.98
90_A 94_L 1.228 0.98
467_E 470_A 1.224 0.98
222_G 248_I 1.224 0.98
460_E 464_R 1.223 0.98
103_S 106_A 1.219 0.98
275_I 279_E 1.208 0.98
104_F 170_I 1.2 0.98
15_L 18_C 1.199 0.98
190_L 193_I 1.198 0.98
433_N 436_A 1.186 0.98
203_I 207_L 1.184 0.98
258_A 510_V 1.183 0.98
100_L 103_S 1.18 0.97
255_M 259_L 1.18 0.97
324_E 327_K 1.179 0.97
125_F 159_F 1.176 0.97
236_P 257_Q 1.175 0.97
64_S 68_N 1.175 0.97
154_G 158_A 1.172 0.97
44_E 174_L 1.167 0.97
335_A 433_N 1.165 0.97
19_G 203_I 1.163 0.97
47_N 173_V 1.159 0.97
112_E 116_G 1.159 0.97
334_Q 338_V 1.158 0.97
373_I 380_V 1.158 0.97
81_D 84_K 1.15 0.97
50_R 170_I 1.148 0.97
56_T 97_S 1.147 0.97
339_Q 430_L 1.145 0.97
249_F 253_K 1.143 0.97
82_D 85_T 1.141 0.97
157_N 161_V 1.14 0.97
237_I 253_K 1.138 0.97
334_Q 446_T 1.133 0.97
31_W 35_D 1.13 0.96
111_N 114_V 1.13 0.96
121_T 159_F 1.125 0.96
458_A 462_Q 1.124 0.96
485_S 489_E 1.122 0.96
89_T 92_A 1.12 0.96
231_G 248_I 1.119 0.96
95_T 98_T 1.118 0.96
499_N 503_H 1.115 0.96
204_S 208_W 1.11 0.96
352_T 355_Q 1.109 0.96
320_R 460_E 1.108 0.96
438_M 441_I 1.106 0.96
473_V 476_M 1.104 0.96
28_M 32_A 1.103 0.96
257_Q 261_G 1.102 0.96
348_Q 432_N 1.098 0.96
489_E 492_V 1.095 0.96
153_Q 157_N 1.092 0.95
252_L 256_Q 1.091 0.95
365_D 369_F 1.09 0.95
478_Q 482_Q 1.09 0.95
424_V 427_G 1.089 0.95
313_G 317_D 1.088 0.95
32_A 188_S 1.082 0.95
296_A 300_Q 1.081 0.95
127_R 130_N 1.081 0.95
86_L 89_T 1.08 0.95
290_R 479_V 1.073 0.95
15_L 21_L 1.072 0.95
226_D 251_S 1.071 0.95
298_L 301_T 1.071 0.95
171_N 175_E 1.068 0.95
7_I 214_I 1.065 0.95
234_A 513_L 1.065 0.95
15_L 207_L 1.064 0.95
267_R 271_Q 1.062 0.95
343_M 434_A 1.061 0.94
207_L 211_R 1.061 0.94
85_T 88_T 1.06 0.94
250_A 253_K 1.059 0.94
241_G 244_E 1.056 0.94
219_A 222_G 1.056 0.94
262_T 266_V 1.055 0.94
182_Q 186_Q 1.053 0.94
89_T 93_S 1.052 0.94
123_K 126_A 1.052 0.94
239_V 253_K 1.05 0.94
369_F 373_I 1.049 0.94
34_R 189_A 1.049 0.94
300_Q 468_Q 1.049 0.94
363_V 409_A 1.048 0.94
5_I 13_L 1.047 0.94
42_Q 46_S 1.047 0.94
419_E 422_N 1.045 0.94
481_Q 485_S 1.044 0.94
360_I 416_L 1.044 0.94
209_W 212_K 1.043 0.94
130_N 133_E 1.041 0.94
222_G 247_A 1.041 0.94
98_T 129_H 1.04 0.94
29_S 199_A 1.04 0.94
180_Q 184_N 1.04 0.94
19_G 22_Q 1.039 0.94
117_L 169_E 1.039 0.94
208_W 212_K 1.038 0.94
303_A 307_Q 1.037 0.94
228_I 252_L 1.037 0.94
92_A 95_T 1.037 0.94
220_I 223_S 1.034 0.93
223_S 227_S 1.034 0.93
40_L 181_S 1.033 0.93
468_Q 472_A 1.033 0.93
431_V 435_A 1.032 0.93
496_Q 499_N 1.032 0.93
443_S 447_R 1.027 0.93
397_G 400_R 1.025 0.93
32_A 35_D 1.025 0.93
485_S 492_V 1.021 0.93
408_Q 411_K 1.019 0.93
310_A 314_Q 1.014 0.93
29_S 43_V 1.014 0.93
287_L 290_R 1.013 0.93
217_P 248_I 1.011 0.92
218_L 248_I 1.01 0.92
461_E 465_G 1.01 0.92
87_M 91_R 1.01 0.92
319_A 459_S 1.009 0.92
215_V 218_L 1.005 0.92
450_D 453_G 1.004 0.92
335_A 338_V 1.003 0.92
232_N 235_R 1.003 0.92
293_Q 296_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3zx6A20.6061000.398Contact Map0.591
1qu7A20.42591000.522Contact Map0.514
2ch7A10.50091000.58Contact Map0.367
3g67A20.39961000.632Contact Map0.694
4i3mA10.31711000.754Contact Map0.497
4gn0A40.195199.40.866Contact Map0.688
2f95B10.305899.30.878Contact Map0.336
2d4uA20.320899.10.888Contact Map0.628
3zccA20.2045990.889Contact Map0.646
4gycB10.2495990.89Contact Map0.389
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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